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Autor:
Zhenyang Li, Jianbin Xiang, Xiaodong Gu, Min-Wei Zhou, Yi Yang, Mengzhen Li, Dongbing Li, Zihao Wang, Chuang Zheng, Zongyou Chen
Publikováno v:
Aging (Albany NY)
Locally recurrent rectal cancer (LRRC) leads to a poor prognosis and appears as a clinically predominant pattern of failure. In this research, whole-exome sequencing (WES) was performed on 21 samples from 8 patients to search for the molecular mechan
Autor:
Jinrui Zhang, Wen Tong, Sai Zhang, Zhixin Zhang, Yi Bai, Hao Wu, Pinsheng Han, Zhongyang Shen, Yamin Zhang, Bing Fu
Publikováno v:
Aging (Albany NY)
Long non-coding RNAs (lncRNAs) are associated with occurrence and development of tumors. Enhancer RNA (eRNA) is a special type of lncRNAs produced from transcription of enhancer elements. The function of eRNAs in tumors have elicited significant atte
Publikováno v:
Aging (Albany NY)
MicroRNAs (miRNAs) contribute to osteoarthritis (OA) development. Nevertheless, the function and mechanism of miR-30b-5p in OA are unclear. In the present article, we gauged the miR-30b-5p level in OA patients and analyzed its correlation with OA sta
Publikováno v:
Aging (Albany NY)
A considerable amount of literature has demonstrated that eukaryotic translation elongation factor 1A (eEF1A) is closely related to tumors. As a newly identified lysine specific methyltransferase targeting eEF1A at Lys-165, too little attention has b
Publikováno v:
Aging (Albany NY)
Esophageal cancer (EC) is one of the most lethal malignancies in humans, and multiple miRNAs have been identified to modulate EC progression by targeting different targets. However, the effect and related mechanism of microRNA-33a-5p (miR-33a-5p) on
Autor:
Jian Guo, Na Wang, Wei Sun, Ping Wang, Qian Zhang, Zuojun Xu, Xiaoyan Jing, Hui Huang, Qun Luo, Shu Xia, Xiaoyu Yang
Publikováno v:
Aging (Albany NY)
Idiopathic pulmonary fibrosis (IPF) mainly occurs in elderly people over the age of sixty. IPF pathogenesis is associated with alveolar epithelial cells (AECs) senescence. Activation of PI3K/AKT signaling induced by insulin-like growth factor 1 (IGF1
Autor:
Shangkun Yuan, Renfang Chen, Zhehao Xiao, Xiaoying Qian, Fen Liu, Yong Wang, Yong Li, Qian Wang, Chen Fang, Biqi Fu, Xiaotong Qiu, Xinwei Zhang
Publikováno v:
Aging (Albany NY)
Neutrophil extracellular traps (NETs) are closely related to cancer progression. NETs-related lncRNAs play crucial roles in non-small-cell lung cancer (NSCLC) but there have been no systematic studies regarding NETs-related long noncoding RNA (lncRNA
Autor:
Mengqi Zhuang, Xiaotong Ding, Wenli Song, Xinzhe Dong, Yang Yu, Huimin Chen, Hui Guan, Zicheng Zhang
Publikováno v:
Aging (Albany NY)
IL-6 is reported to be the main upstream activator, instead of the downstream target of JAK2/STAT3. This study is intended to explore the correlation of IL-6 and JAK2/STAT3 signaling pathway with clinicopathological features and prognosis in nasophar
Autor:
Xianlong Fang, Ning Cai, Yuxin Zhang, Jingyu Liao, Jingyuan Wen, Liang Chu, Weiqi Xu, Xiaoping Chen, Bixiang Zhang, Yu Wu
Publikováno v:
Aging (Albany NY)
Liver cancer is the sixth most common malignancy and the fourth leading cause of cancer-related death worldwide. Hepatocellular carcinoma (HCC) is the primary type of liver cancer. Small nucleolar RNA (snoRNA) dysfunctions have been associated with c
Publikováno v:
Aging (Albany NY)
There has been increasing evidence that microRNAs (miRNAs) are related to glioma progression, and that genetically engineered mesenchymal stem cells (MSCs) can inhibit the growth of gliomas. However, the underlying mechanism of bone marrow-MSCs (BM--