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Publikováno v:
BioMed Research International, Vol 2021 (2021)
Background. Colorectal cancer (CRC) is recognized as one of the most common malignancies with a high mortality rate worldwide, supporting the necessity for an effective novel antitumor drug to improve current therapy’s effectiveness. Substance P (S
Publikováno v:
Case Reports in Oncological Medicine, Vol 2021 (2021)
Case Reports in Oncological Medicine
Case Reports in Oncological Medicine
Introduction. Renal cell carcinoma is responsible for 3% of all cancers, with the highest incidence occurring in Western countries. Additionally, in patients with osseous metastasis, only 3% occur within the tibia. Rarely, a patient presents with a p
Publikováno v:
Case Reports in Infectious Diseases
Case Reports in Infectious Diseases, Vol 2021 (2021)
Case Reports in Infectious Diseases, Vol 2021 (2021)
Cryptococcal meningitis, which has a high mortality rate, is rare in immunocompetent children. Although many immunocompromised conditions are identified as predisposing factors, congenital heart disease in children is not well recognized as a predisp
Autor:
Sang Kyum Kim, Ji Hye Im, Suntae Kim, Wankyu Kim, Sun Jo Kim, Young Jae Choi, Ji-Yoon Lee, Sung Won Kwon, Keon Wook Kang
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Background. Although the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR- TKI) therapy has been proven in non-small cell lung cancer (NSCLC) patients, acquired resistance to EGFR-TKIs presents a serious clinical problem.
Autor:
Kyle J. Burghardt, Berhane Seyoum, Aktham Mestareehi, Abdullah Mallisho, Zaher Msallaty, Zhengping Yi, Anjaneyulu Kowluru, Xiangmin Zhang
Publikováno v:
Journal of Diabetes Research
Journal of Diabetes Research, Vol 2021 (2021)
Journal of Diabetes Research, Vol 2021 (2021)
Context. Skeletal muscle insulin resistance is one of the primary contributors of type 2 diabetes (T2D). Metformin is the first-line drug for the treatment of T2D. The primary effects of metformin include decreasing glucose production in the liver an
Publikováno v:
Disease Markers
Disease Markers, Vol 2021 (2021)
Disease Markers, Vol 2021 (2021)
Background. Obliterative bronchiolitis (OB) was a main cause of deterioration of long-term prognosis in lung transplant recipients after the first posttransplant year. Proinflammatory cytokine interleukin-18 (IL-18) strengthened both the natural immu
Publikováno v:
Journal of Oncology
Journal of Oncology, Vol 2021 (2021)
Journal of Oncology, Vol 2021 (2021)
Background. Kidney renal clear cell carcinoma (KIRC) is the most prevalent renal malignancy. The therapeutic strategies for advanced KIRC are very few, with only sunitinib being widely approved. Mutations in the PIK3CA gene can affect tumor cell prol
Publikováno v:
Journal of Oncology, Vol 2021 (2021)
Journal of Oncology
Journal of Oncology
Background. Propofol is an anesthetic commonly used clinically and has been found to have antitumor activity in various cancers. The purpose of this study was to investigate the role of propofol in hepatoblastoma (HB). Methods. CCK-8 and transwell we
Autor:
Jérôme Montnach, Michel Seve, A. Blangy-Letheule, Bertrand Rozec, A. Persello, Benjamin Lauzier, Virginie Aillerie, Sandrine Bourgoin-Voillard, Valérie Cunin, Sylvie Michelland, M. De Waard, Angélique Erraud, F. Souab, J. Dhot
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Introduction. Septic shock is a systemic inflammatory response syndrome associated with organ failures. Earlier clinical diagnosis would be of benefit to a decrease in the mortality rate. However, there is currently a lack of predictive biomarkers. T
Publikováno v:
Case Reports in Infectious Diseases
Case Reports in Infectious Diseases, Vol 2021 (2021)
Case Reports in Infectious Diseases, Vol 2021 (2021)
Introduction. Coupled with the increasing use of indwelling vascular catheters and prosthetic cardiac valves is an uptrend in sepsis secondary to fungemia. An insidious onset often shrouds the initial diagnosis, contributing to poor outcomes. Candida