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Publikováno v:
BioMed Research International, Vol 2021 (2021)
Background. Colorectal cancer (CRC) is recognized as one of the most common malignancies with a high mortality rate worldwide, supporting the necessity for an effective novel antitumor drug to improve current therapy’s effectiveness. Substance P (S
Autor:
Sang Kyum Kim, Ji Hye Im, Suntae Kim, Wankyu Kim, Sun Jo Kim, Young Jae Choi, Ji-Yoon Lee, Sung Won Kwon, Keon Wook Kang
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Background. Although the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR- TKI) therapy has been proven in non-small cell lung cancer (NSCLC) patients, acquired resistance to EGFR-TKIs presents a serious clinical problem.
Autor:
Kyle J. Burghardt, Berhane Seyoum, Aktham Mestareehi, Abdullah Mallisho, Zaher Msallaty, Zhengping Yi, Anjaneyulu Kowluru, Xiangmin Zhang
Publikováno v:
Journal of Diabetes Research
Journal of Diabetes Research, Vol 2021 (2021)
Journal of Diabetes Research, Vol 2021 (2021)
Context. Skeletal muscle insulin resistance is one of the primary contributors of type 2 diabetes (T2D). Metformin is the first-line drug for the treatment of T2D. The primary effects of metformin include decreasing glucose production in the liver an
Publikováno v:
Disease Markers
Disease Markers, Vol 2021 (2021)
Disease Markers, Vol 2021 (2021)
Background. Obliterative bronchiolitis (OB) was a main cause of deterioration of long-term prognosis in lung transplant recipients after the first posttransplant year. Proinflammatory cytokine interleukin-18 (IL-18) strengthened both the natural immu
Publikováno v:
Journal of Oncology
Journal of Oncology, Vol 2021 (2021)
Journal of Oncology, Vol 2021 (2021)
Background. Kidney renal clear cell carcinoma (KIRC) is the most prevalent renal malignancy. The therapeutic strategies for advanced KIRC are very few, with only sunitinib being widely approved. Mutations in the PIK3CA gene can affect tumor cell prol
Publikováno v:
Journal of Oncology, Vol 2021 (2021)
Journal of Oncology
Journal of Oncology
Background. Propofol is an anesthetic commonly used clinically and has been found to have antitumor activity in various cancers. The purpose of this study was to investigate the role of propofol in hepatoblastoma (HB). Methods. CCK-8 and transwell we
Autor:
Jérôme Montnach, Michel Seve, A. Blangy-Letheule, Bertrand Rozec, A. Persello, Benjamin Lauzier, Virginie Aillerie, Sandrine Bourgoin-Voillard, Valérie Cunin, Sylvie Michelland, M. De Waard, Angélique Erraud, F. Souab, J. Dhot
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Introduction. Septic shock is a systemic inflammatory response syndrome associated with organ failures. Earlier clinical diagnosis would be of benefit to a decrease in the mortality rate. However, there is currently a lack of predictive biomarkers. T
Publikováno v:
Journal of Immunology Research
Journal of Immunology Research, Vol 2021 (2021)
Journal of Immunology Research, Vol 2021 (2021)
Breast cancer is one of the most common cancers among females and is associated with high mortality and morbidity rates. Several studies have demonstrated that combination treatments with natural products and tamoxifen can improve the sensitivity and
Publikováno v:
International Journal of Microbiology
International Journal of Microbiology, Vol 2021 (2021)
International Journal of Microbiology, Vol 2021 (2021)
In recent years, the prevalence of carbapenem-resistant Pseudomonas aeruginosa isolates has become a worldwide concern. Rapid and accurate detection of carbapenemase-producing P. aeruginosa isolates is so important. The aim of this study was to evalu
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2021 (2021)
Mediators of Inflammation, Vol 2021 (2021)
Paraquat (PQ) can cause multiorgan failure including acute kidney injury (AKI). Our prior study showed that Toll-interacting protein (TOLLIP) protected against PQ-induced acute lung injury. However, the role of TOLLIP in PQ-induced AKI remains undefi