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Publikováno v:
Journal of Oncology
Journal of Oncology, Vol 2021 (2021)
Journal of Oncology, Vol 2021 (2021)
Background. Kidney renal clear cell carcinoma (KIRC) is the most prevalent renal malignancy. The therapeutic strategies for advanced KIRC are very few, with only sunitinib being widely approved. Mutations in the PIK3CA gene can affect tumor cell prol
Publikováno v:
Journal of Oncology, Vol 2021 (2021)
Journal of Oncology
Journal of Oncology
Background. Propofol is an anesthetic commonly used clinically and has been found to have antitumor activity in various cancers. The purpose of this study was to investigate the role of propofol in hepatoblastoma (HB). Methods. CCK-8 and transwell we
Autor:
Jérôme Montnach, Michel Seve, A. Blangy-Letheule, Bertrand Rozec, A. Persello, Benjamin Lauzier, Virginie Aillerie, Sandrine Bourgoin-Voillard, Valérie Cunin, Sylvie Michelland, M. De Waard, Angélique Erraud, F. Souab, J. Dhot
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Introduction. Septic shock is a systemic inflammatory response syndrome associated with organ failures. Earlier clinical diagnosis would be of benefit to a decrease in the mortality rate. However, there is currently a lack of predictive biomarkers. T
Autor:
Zhongqing Wei, Bin Ni, Yunpeng Shao, Baixin Shen, Le Shu, Zhengsen Chen, Yi Huang, Nebiyu Elias Tamrat
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Objective. To investigate the protective effect and molecular mechanism of nuclear factor E2-related factor 2 (Nrf2) pathway in interstitial cystitis (IC). Methods. We established a mouse model of IC by cyclophosphamide (CYP) in wild-type mice and Nr
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2021 (2021)
BioMed Research International, Vol 2021 (2021)
Introduction. This study was aimed to investigate the effects of N-acetylcysteine (NAC) on chronic obstructive pulmonary disease (COPD) and the change of Th17/Treg cytokine imbalance. Material and Methods. A total of 121 patients with stable COPD at
Publikováno v:
BioMed Research International, Vol 2021 (2021)
BioMed Research International
BioMed Research International
Background. Autophagy is likely altered in patients with endometriosis. Ovarian steroid hormones seem to affect this changing of the autophagic process. Objective. To study the effect of combined oral contraceptive (COC) pills on the expression of au
Publikováno v:
Gastroenterology Research and Practice
Gastroenterology Research and Practice, Vol 2021 (2021)
Gastroenterology Research and Practice, Vol 2021 (2021)
lncRNA is a key epigenetic regulator in biological processes. In the human cancer transcriptome library MiTranscriptome, we identified GAU1 as the top upregulated lncRNA in colorectal cancer (CRC) by sample set enrichment analysis (overexpression ran
Autor:
Peili Bu, Lingxin Liu, Jianmin Yang, Lin Xie, Mengying Suo, Chunmei Zhang, Yan Qi, Chen Zhang, Xuehui Zheng, Jingyuan Li, Chang Ma
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative stress and apoptosis play a vital role in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The purpose of our study was to investigate the protective effects and mechanisms of melatonin against CI-AKI in a CI-AKI mouse mod
Publikováno v:
Journal of Oncology, Vol 2021 (2021)
Journal of Oncology
Journal of Oncology
The morbidity and mortality of lung cancer remain one of the highest among multiple cancers, respectively. Small-Cell Lung Cancer (SCLC) accounts for around 10%–15% of all lung cancers. Approximately two-thirds of the diagnosed SCLCs are in extensi
Autor:
Fengxian Qin, Fan Yang, Xuexiang Liu, Song Shi, Yujie Huang, Jifei Chen, Wen-wu Liang, Lin Miao, Xiao-mou Wei
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2021 (2021)
Mediators of Inflammation, Vol 2021 (2021)
Background. The functional characteristics of NLRP3 in the pathogenesis of coxsackievirus B3- (CVB3-) induced viral myocarditis (VMC) have not been fully elucidated, and the targeted therapeutic effect of NLRP3 or its related pathway in VMC has not b