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Autor:
Adeline Vanderver, Asako Takanohashi, Nicole Ulrick, Elizabeth B. Rand, Sarah Woidill, Francesco Gavazzi, Joseph M. McMann, Laura Adang, Zachary Cross, Justine Shults
Publikováno v:
Neuropediatrics
Aicardi-Goutières syndrome (AGS) is a monogenic type-I interferonopathy that results in neurologic injury. The systemic impact of sustained interferon activation is less well characterized. Liver inflammation is known to be associated with the neona
Autor:
Patrick Haider, Joseph Pultar, Johann Wojta, Svitlana Demyanets, Patricia P. Wadowski, Simon Panzer, Beate Eichelberger, Stefan Stojkovic, Silvia Lee, Constantin Weikert, Christian Hengstenberg, Thomas Gremmel
Publikováno v:
Thrombosis and Haemostasis. 121:913-922
Background Monocyte–platelet aggregates (MPAs) are a sensitive marker of in vivo platelet activation in acute coronary syndrome (ACS) and associated with clinical outcomes. MicroRNAs (miRs) play an important role in the regulation of platelet activ
Autor:
Christophe Demattei, E. Nouvellon, Marielle Herzog, Mathieu Fortier, E. Mousty, Vincent Letouzey, Laura Vincent, Eric Mercier, Guillaume Rommelaere, Jean-Christophe Gris, Sylvie Bouvier
Publikováno v:
Thrombosis and Haemostasis. 121:877-890
NETosis is an innate immune response occurring after infection or inflammation: activated neutrophils expel decondensed DNA in complex with histones into the extracellular environment in a controlled manner. It activates coagulation and fuels the ris
Autor:
Anna Vikerfors, Kristina Nilsson-Ekdahl, Maria Bruzelius, Bo Nilsson, Lennart Truedsson, Iva Gunnarsson, Elisabet Svenungsson, Agneta Zickert, Aleksandra Antovic, Giorgia Grosso, Kerstin Sandholm
Publikováno v:
Thrombosis and Haemostasis. 121:1299-1309
Background Low levels of total C4b-binding protein (C4BPt), a circulating inhibitor of the classical/lectin complement pathways, were observed in patients with antiphospholipid antibodies (aPLs) and during warfarin treatment. Objectives To investigat
Publikováno v:
Seminars in Liver Disease. 41:103-108
Intrahepatic cholestasis of pregnancy (ICP) is a common disorder in the second half of pregnancy characterized by pruritus and elevated serum bile acids (BAs) with spontaneous resolution after delivery. ICP carries a risk of adverse effects on the fe
Publikováno v:
Neuropediatrics. 52:394-397
Sjögren's syndrome is a systemic autoimmune disease that classically presents with xerophthalmia and xerostomia. However, neurological manifestations occur in 10 to 60% of patients with Sjögren's syndrome and can often precede classic sicca symptom
Publikováno v:
Hämostaseologie. 40:642-648
Objective This article aims to analyze the phenotype and genotype of an inherited dysfibrinogenemia pedigree associated with a heterozygous mutation in the FGA gene, and to investigate the pathogenesis of this disease. Clinical Presentation The proba
Autor:
Elisa Vogeler, Maja-Theresa Dieterlen, Jens Garbade, Sven Lehmann, Michael A. Borger, Anna L. Meyer, K. Jawad
Publikováno v:
The Thoracic and Cardiovascular Surgeon. 69:518-525
Background The exact monitoring of the therapeutic-range international normalized ratio (INR) after left ventricular assist device (LVAD) implantation is an important aim to reduce the risk of thrombosis or bleeding complications. Service providers o
Autor:
Doris Cunha-Goncalves, Federico Bianco, Fabrizio Salomone, Anders Nord, Rikard Linner, Martin Schlun, Francesca Ricci
Publikováno v:
American Journal of Perinatology. 39:1001-1007
Objective: It is not known how much surfactant must be nebulized to reach a lung dose of phospholipids equivalent to that obtained by the instillation of 200 mg/kg of surfactant. We aimed to assess the feasibility of nebulizing a high-dose of poracta
Publikováno v:
Drug Research. 71:157-165
The aim of this study is to investigate whether sitagliptin can be used as an initial drug for T2DM and to evaluate its effects on metabolic parameters in relation to its glycemic efficacies. The subjects received 25−50 mg/day sitagliptin monothera