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Publikováno v:
Frontiers in Medicine. 9
Background: Docosahexaenoic acid (DHA) has been reported to slow the tumor growth and improve prognosis, and been used to co-operate with many other chemotherapy medicines. Up to now, survey focuses on the interaction between DHA and radiation is rel
Autor:
Hong-Xin Kang, Juan Li, Yi-Fan Miao, Xiajia Wu, Xian-Lin Zhao, Qian Hu, Cong Li, Lv Zhu, Wen-Fu Tang, Mei-Hua Wan, Jia-Qi Yao
Publikováno v:
Frontiers in Pharmacology. 13
Background: Emodin, one of the most dominant components of the traditional Chinese medicine rhubarb, has been utilized to treat acute pancreatitis (AP). Acute lung injury (ALI) is one of the most common complications of acute pancreatitis, leading to
Autor:
Ricardo José Nunes, Larissa Sens, Iris Mattos Santos-Pirath, Tiago Tizziani, Bruna Fischer Duarte, Patricia Alves Almeida, Maria Cláudia Santos-Silva, Mariana Franzoni Maioral, Laura Otto Walter, Aldo Sena de Oliveira, Douglas Bauer Speer, Luiz Felipe de Souza
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 24 (2021)
Background: Current therapies for acute leukemias (ALs) are associated with severe adverse reactions and high relapse rates, which makes the search for new antileukemic agents a necessity. Therefore, the aim of this study was to evaluate the effects
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Staphylococcus aureus causes severe, life-threatening infections that often are complicated by severe local and systemic pathologies with non-healing lesions. A classic example is S. aureus infective endocarditis (IE), where the secreted hemolysin β
Autor:
Yongsheng Ruan, Hye Na Kim, Heather A. Ogana, Zesheng Wan, Samantha Hurwitz, Cydney Nichols, Nour Abdel-Azim, Ariana Coba, Seyoung Seo, Yong-Hwee Eddie Loh, Eun Ji Gang, Hisham Abdel-Azim, Chih-Lin Hsieh, Michael R. Lieber, Chintan Parekh, Dhananjaya Pal, Deepa Bhojwani, Donald L. Durden, Yong-Mi Kim
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology
Frontiers in Oncology
The PI3K/Akt pathway—and in particular PI3Kδ—is known for its role in drug resistant B-cell acute lymphoblastic leukemia (B-ALL) and it is often upregulated in refractory or relapsed B-ALL. Myc proteins are transcription factors responsible for
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences, Vol 8 (2021)
The knowledge of the metabolic processes of designed metallodrugs for cancer treatment is an area that has been not profoundly studied. Casiopeina IIgly (CasIIgly), which belongs to the Casiopeínas® family, is a copper (II) coordination compound th
Autor:
Amber Dp. Doyle, Yosef Landesman, Jack G. Fisher, Francesco Forconi, Peter Johnson, Matthew D. Blunt, Christopher J. Walker, Salim I. Khakoo, Mark S. Cragg
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology, Vol 11 (2021)
Selinexor is an FDA approved selective inhibitor of the nuclear export protein exportin-1 (XPO1) and causes specific cancer cell death via nuclear accumulation of tumor suppressor proteins. Design of rational studies for the use of selinexor in combi
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 22, Iss 1 (2019)
Background: Although previous studies demonstrated an anticancer effect for the ligands of peroxisome proliferator-activated receptor gamma (PPARγ) through activation of its anti-inflammatory responses, nevertheless the anti-tumor mechanism of PPAR
Autor:
Neelam Mishra, Kavita Rana, Siva Deepthi Seelam, Rakesh Kumar, Vijyendra Pandey, Bharathi P. Salimath, Dayanand Agsar
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology
A biosurfactant producing bacterium was identified as Pseudomonas aeruginosa DNM50 based on molecular characterization (NCBI accession no. MK351591). Structural characterization using MALDI-TOF revealed the presence of 12 different congeners of rhamn
Autor:
Hongyang Lu, Hongyan Zhang, Zeng Wang, Caixing Sun, Qinglin Li, Liang Xia, Mengying Zheng, Huangjie Zhang
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology, Vol 11 (2021)
Glioma is the common primary craniocerebral malignancy with unfavorable prognosis. It is currently treated by surgical resection supplemented by radiotherapy, although the resistance of glioma cells to radiation limits the therapeutic outcomes. The h