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Publikováno v:
Pathology and Oncology Research
Introduction: Ki67 value and its variation before and after neoadjuvant chemotherapy are commonly tested in relation to breast cancer patient prognosis. This study aims to quantify the extent of changes in Ki67 proliferation pre- and post-neoadjuvant
Autor:
Hang Chen, Zhi-Bin Ke, Hai Cai, Yun-Zhi Lin, Qing-Shui Zheng, Ning Xu, Yong Wei, Xue-Yi Xue, Jun-Ming Zhu, Qi Huang
Publikováno v:
Pathology and Oncology Research
Objective: To develop and validate ubiquitination-related molecular subtypes and a novel prognostic index using ubiquitination-related genes (URGs) for patients with bladder cancer (BCa).Materials and Methods: We downloaded the clinical data and tran
Publikováno v:
Pathology and Oncology Research
Background: The preoperative systemic inflammation response index (SIRI), based on peripheral neutrophil (N), monocyte (M), and lymphocyte (L) counts, has shown mounting evidence as an effective prognostic indicator in some malignant tumors. The aim
Autor:
Hinda Najem, Anantha Marisetty, Craig Horbinski, James Long, Jason T. Huse, Isabella C. Glitza Oliva, Sherise D. Ferguson, Priya U. Kumthekar, Derek A. Wainwright, Peiwen Chen, Maciej S. Lesniak, Jared K. Burks, Amy B. Heimberger
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Leptomeningeal disease (LMD) in melanoma patients is associated with significant neurological sequela and has a dismal outcome, with survival measured typically in weeks. Despite the therapeutic benefit of targeted therapies and immunotherapies for S
Publikováno v:
Pathology and Oncology Research
Background: The treatment choice for completely resected stage IIIA/N2 non-small cell lung cancer (NSCLC) patients is still controversial now. Our study aims to identify potential prognostic factors in stage IIIA/N2 NSCLC patients with complete surgi
Publikováno v:
Pathology and Oncology Research
Background: PD-L1 expression differs from 19 to 92% in various cancer subtypes. Its expression carries a worse prognostic value in various malignancies and could also be used as a predictive marker for immune checkpoint inhibitor response. This study
Autor:
Zsolt Abonyi-Tóth, Krisztián Horváth, Balázs Nagy, László Urbán, Veronika Sárosi, Krisztina Bogos, Zoltán Polányi, Zoltán Kiss, Judit Moldvay, Zsófia Nagy-Erdei, Nóra Bittner, Lilla Tamási, Andrea Daniel, Gyula Ostoros, Aladár Vastag, György Rokszin, Veronika Müller, Gabriella Gálffy, Zoltán Vokó
Publikováno v:
Pathology and Oncology Research
Background: No assessment was conducted describing the age and gender specific epidemiology of lung cancer (LC) prior to 2018 in Hungary, thus the objective of this study was to appraise the detailed epidemiology of lung cancer (ICD-10 C34) in Hungar
Publikováno v:
Pathology and Oncology Research
Background: The objective was to explore the discordance in the expression of the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 between primary and recurrent/metastatic lesions in patie
Autor:
Junling Zhang, Bing Qian, Yangyang Yu, Shanhui Liang, Wenbin Shen, Guoqiang Wang, Jin Lu, Zhi Jiang, Yuzi Zhang, Boer Shan, Yuezong Bai
Publikováno v:
Pathology and Oncology Research
Objective: We conducted this study to characterize somatic genomic alterations in circulating tumor DNA (ctDNA) from patients with ovarian cancer and compare GAs detected in ctDNA with tissue databases.Methods: Hybrid capture-next generation sequenci
Autor:
Sarah A Hakim, Hoda H Abou Gabal
Publikováno v:
Pathology and Oncology Research
Background: Epithelioid mesothelioma (EM) is the commonest subtype of malignant pleural mesothelioma. Its histopathological discrimination from reactive mesothelial hyperplasia (RMH) could be challenging. Thus, an immunohistochemical panel is mandato