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Autor:
S R Abd El-Khalik, M A Elsebaey, Marwa Mohamed Atef, Sherif Abd-Al Fattah Saber, Yasser Mostafa Hafez, Alaa I. Amer
Publikováno v:
British Journal of Biomedical Science. 78:122-129
BACKGROUND Colorectal cancer is one of the most common cancers worldwide and a major cause of cancer-related death. Thus molecular biomarkers for colorectal cancer have been proposed. The role of long non-coding RNA EGFR-AS1 in colorectal cancer is s
Autor:
Csurgay, Katalin, Zalatnai, Attila, Benczik, Márta, Csomó, Benedek Krisztián, Horváth, Ferenc, Lőrincz, Ádám, Komlós, György, Németh, Zsolt
Publikováno v:
Pathology and Oncology Research
The etiological factors of squamous cell carcinomas of the head and neck have been well known for a long time. It is also well known that the incidence of oral cancer diagnosed in younger patients is on the rise. Due to the young age of these patient
Autor:
Anne Helene Køstner, Patricia Switten Nielsen, Jeanette Baehr Georgsen, Erik Thorlund Parner, Mette Bak Nielsen, Christian Kersten, Torben Steiniche
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Køstner, A H, Nielsen, P S, Georgsen, J B, Parner, E T, Nielsen, M B, Kersten, C & Steiniche, T 2021, ' Systemic inflammation associates with a myeloid inflamed tumor microenvironment in primary resected colon cancer—May cold tumors simply be too hot? ', Frontiers in Immunology, vol. 12, 716342 . https://doi.org/10.3389/fimmu.2021.716342
Frontiers in Immunology, Vol 12 (2021)
Køstner, A H, Nielsen, P S, Georgsen, J B, Parner, E T, Nielsen, M B, Kersten, C & Steiniche, T 2021, ' Systemic inflammation associates with a myeloid inflamed tumor microenvironment in primary resected colon cancer—May cold tumors simply be too hot? ', Frontiers in Immunology, vol. 12, 716342 . https://doi.org/10.3389/fimmu.2021.716342
Systemic inflammation measured by the acute-phase protein CRP associates with poor outcome across cancer types. In contrast, local tumor-associated inflammation, primarily evaluated by T-lymphocytes, correlates with favorable prognosis. Yet, little i
Publikováno v:
Pathology and Oncology Research
Background: PD-L1 expression differs from 19 to 92% in various cancer subtypes. Its expression carries a worse prognostic value in various malignancies and could also be used as a predictive marker for immune checkpoint inhibitor response. This study
Autor:
Lobna Ben Ammar, Wajih Kaabachi, Elhem Cheour, Nadia Sassi, Dorra Elhaj Mahmoud, S. Jemmali, Lamjed Tarhouni, Maryam Kallel-Sellami, Myriam Moalla, Amel Mokhtar, Lilia Laadhar, Sonia Rekik
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
BackgroundTissue derived fibroblast-like synoviocytes (td-FLS) are key actors in pannus formation and contribute to joint destruction and inflammation during rheumatoid arthritis (RA). Several members of the Wnt family, including Wnt5a, may contribut
Autor:
Sarah A Hakim, Hoda H Abou Gabal
Publikováno v:
Pathology and Oncology Research
Background: Epithelioid mesothelioma (EM) is the commonest subtype of malignant pleural mesothelioma. Its histopathological discrimination from reactive mesothelial hyperplasia (RMH) could be challenging. Thus, an immunohistochemical panel is mandato
Autor:
Roberto Sánchez-Reyes, Luis Cabrera-Miranda, Héctor Aquiles Maldonado-Martínez, Suraj Samtani-Bassarmal, Oscar Arrieta, Graciela Cruz-Rico, Luis Lara-Mejía, Xitlally Popa-Navarro, Rodrigo Catalán, Dennis López-Sánchez, Alejandro Avilés-Salas
Publikováno v:
Pathology and Oncology Research
Background: Programmed cell death-ligand 1 (PD-L1) protein expression is one of the most extensively studied biomarkers in patients with non-small cell lung cancer (NSCLC). However, there is scarce information regarding its association with distinct
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Regulatory T cells (Tregs) play a critical role in the maintenance of immune tolerance and tumor evasion. However, the relative low proportion of these cells in peripheral blood and tissues has hindered many studies. We sought to establish a rapamyci
Autor:
Brian M. Alexander, Charlotte Brown, Douglas I. Lin, Deborah L. McEwan, N. Lynn Ferguson, Pratheesh Sathyan, Shakti H. Ramkissoon, Prasanth Reddy, Jeffrey S. Ross, Samantha Morley, Richard S.P. Huang, Amanda Hemmerich, Erik A. Williams, Jonathan Keith Killian, Garrett M. Frampton, Jeffrey M. Venstrom, Clarence Owens, Oliver Holmes, James Haberberger, Natalie Danziger, Rachel Anhorn, Jo-Anne Vergilio, Michael B. Cohen, Julia A. Elvin, Eric Allan Severson, Claire Edgerly, Kimberly McGregor, Daniel L. Duncan
Publikováno v:
Pathology and Oncology Research
Comprehensive genomic profiling (CGP) and immunohistochemistry (IHC) are important biomarker tools used for patients with non-small cell lung cancer (NSCLC) given the expanding number of standard-of-care therapies that require companion diagnostic te
Autor:
Rania H. Younis, Ioana Ghita, Manar Elnaggar, Risa Chaisuparat, Vasileios Ionas Theofilou, Donita Dyalram, Robert A. Ord, Eduardo Davila, Luke J. Tallon, John C. Papadimitriou, Tonya J. Webb, Søren M. Bentzen, Joshua E. Lubek
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Semaphorin 4D (Sema4D) is a glycoprotein that is expressed by several tumors and immune cells. It can function as a membrane bound protein or as a cleaved soluble protein (sSema4D). We sought to investigate the translational potential of plasma sSema