Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Preclinical research"'
Autor:
Thomas Hartung
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
Animals like mice and rats have long been used in medical research to help understand disease and test potential new treatments before human trials. However, while animal studies have contributed to important advances, too much reliance on animal mod
Externí odkaz:
https://doaj.org/article/d6c68c28933a414db9c90ffa3f8e778d
Autor:
Adrienne B. Narrowe, Johanna M. S. Lemons, Karley K. Mahalak, Jenni Firrman, Pieter Van den Abbeele, Aurélien Baudot, Stef Deyaert, Yanfang Li, Liangli (Lucy) Yu, LinShu Liu
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
The genus Senna contains globally distributed plant species of which the leaves, roots, and seeds have multiple traditional medicinal and nutritional uses. Notable chemical compounds derived from Senna spp. include sennosides and emodin which have be
Externí odkaz:
https://doaj.org/article/5fc658b665e942ed9c17f9054793756f
Autor:
Michael Obrecht, Stefan Zurbruegg, Nathalie Accart, Christian Lambert, Arno Doelemeyer, Birgit Ledermann, Nicolau Beckmann
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The 3Rs principles—reduction, refinement, replacement—are at the core of preclinical research within drug discovery, which still relies to a great extent on the availability of models of disease in animals. Minimizing their distress, reducing the
Externí odkaz:
https://doaj.org/article/9555f460d3f64bb6ac866e3ea49e2a90
Autor:
Zhe-Lun Yang, Ze-Yan Liang, Yi-Ke Lin, Fa-Bin Lin, Jian Rao, Xiong-Jie Xu, Chun-Hua Wang, Chun-Mei Chen
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
BackgroundThere was still no effective treatment for traumatic brain injury (TBI). Recently, many preclinical studies had shown promising efficacy of extracellular vesicles (EVs) from various cell sources. Our aim was to compare which cell-derived EV
Externí odkaz:
https://doaj.org/article/1d5bc9bdf6d145abbbd32ed282234918
Autor:
Paulina Nunez-Badinez, Alexis Laux-Biehlmann, Michael D. Hayward, Olesia Buiakova, Thomas M. Zollner, Jens Nagel
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 17 (2023)
Endometriosis is a chronic, hormone-dependent, inflammatory disease, characterized by the presence and growth of endometrial tissue outside the uterine cavity. It is associated with moderate to severe pelvic and abdominal pain symptoms, subfertility
Externí odkaz:
https://doaj.org/article/c90e3ddbc64c42ea80f0e2f21ac7dee4
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/15f32d17cd6a4cdb9fd91f53dc66745f
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/aaba5918d9b441738ed832e6cf34b3d9
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/8cb2020b73634d818393e2c886710807
Autor:
Iris Sanou, Jillis van Maaren, Jitske Eliveld, Qijing Lei, Andreas Meißner, Annemieke A. de Melker, Geert Hamer, Ans M. M. van Pelt, Callista L. Mulder
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Fertility preservation via biobanking of testicular tissue retrieved from testicular biopsies is now generally recommended for boys who need to undergo gonadotoxic treatment prior to the onset of puberty, as a source of spermatogonial stem cells (SSC
Externí odkaz:
https://doaj.org/article/71ae5449de4842198e9733fbb654d199
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Cancer is a complex multifactorial disease that results from alterations in many physiological and biochemical functions. Over the last few decades, it has become clear that cancer cells can acquire multidrug resistance to conventional anticancer dru
Externí odkaz:
https://doaj.org/article/386946d298cc459fb4716474bbf39c65