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pro vyhledávání: '"John Dodd"'
Autor:
John Dodd, Robert Jordan, Marie Makhlina, Keith Barnett, Ad Roffel, Carl Spana, Alison Obr, Priyanka Dhingra, Paul S. Kayne
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPL8177 is a potent and selective agonist of the melanocortin 1 receptor (MC1R). PL8177 has shown efficacy in reversing intestinal inflammation in a cannulated rat ulcerative colitis model. To facilitate oral delivery, a novel, polymer-enc
Externí odkaz:
https://doaj.org/article/6822292f0ed94f7caf82349ccec80548
Autor:
Jose Garrido-Mesa, Bethan Lynne Thomas, John Dodd, Carl Spana, Mauro Perretti, Trinidad Montero-Melendez
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundMelanocortins are peptides endowed with anti-inflammatory and pro-resolving activities. Many of these effects are mediated by the Melanocortin receptor 1 (MC1) as reported in several experimental settings. As such, MC1 can be a viable targe
Externí odkaz:
https://doaj.org/article/4e330a5294894f3c85864a0a6b9f55f9
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2019)
Background: The melanocortin α-melanocyte stimulating hormone (α-MSH), an endogenous peptide with high affinity for the melanocortin 1 receptor (MC1r), has demonstrated prevention and reversal of intestinal and ocular inflammation in animal models.
Externí odkaz:
https://doaj.org/article/963d6da34ea948598e8565ed64415d11