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Autor:
Meryam Cheloufi, Alaa Kazhalawi, Anne Pinton, Mona Rahmati, Lucie Chevrier, Laura Prat-ellenberg, Anne-Sophie Michel, Geraldine Dray, Arsène Mekinian, Gilles Kayem, Nathalie Lédée
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2021, 12, pp.656701. ⟨10.3389/fimmu.2021.656701⟩
Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2021, 12, pp.656701. ⟨10.3389/fimmu.2021.656701⟩
IntroductionThe endometrial immune profiling is an innovative approach based on the analysis of the local immune reaction occurring in the endometrium at the time of the embryo implantation. By documenting the local immune activation during the perio
Autor:
Yuchuan Jiang, Siliang Chen, Qiang Li, Junjie Liang, Weida Lin, Jinying Li, Zhilong Liu, Mingbo Wen, Mingrong Cao, Jian Hong
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
BackgroundNumerous cancer types present the aberrant TANK-binding kinase 1 (TBK1) expression, which plays an important role in driving inflammation and innate immunity. However, the prognostic role of TBK1 and its relationship with immune cell infilt
Autor:
Xuan Zhou, Sanfang Tu, Chunsheng Wang, Rui Huang, Lan Deng, Chaoyang Song, Chunyan Yue, Yanjie He, Jilong Yang, Zhao Liang, Anqin Wu, Meifang Li, Weijun Zhou, Jingwen Du, Zhenling Guo, Yongqian Li, Cheng Jiao, Yuchen Liu, Lung-Ji Chang, Yuhua Li
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
BackgroundThe administration of second- or third-generation anti-CD19 chimeric antigen receptor (CAR) T cells has remarkably improved the survival of patients with relapsed or refractory B cell malignancies. However, there are limited clinical result
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Despite the impressive impact of PD-1 (programmed cell death protein 1)-targeted cancer immunotherapy, a great part of patients with cancer fail to respond. PD-1 impact on immune cells in addition to T cells, and the synergistic role of PD-1 with oth
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Chronic graft-versus-host-disease (cGVHD) is the leading cause of late non-relapse mortality after allogeneic hematopoietic stem cell transplantation(HSCT). There is no standard therapy for patients refractory or dependent to corticosteroid treatment
Autor:
Xing-Chen Ding, Liang-Liang Wang, Yu-Fang Zhu, Yan-Dong Li, Shu-Lun Nie, Jia Yang, Hua Liang, Ralph R. Weichselbaum, Jin-Ming Yu, Man Hu
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Background The programmed cell death ligand 1 (PD-L1) plays a key role in glioma development. However, due to the specificity of glioma’s anatomical position, the role of its expression as a tumor biomarker is limited. It has been proven that the l
Autor:
Natalie Zwing, Henrik Failmezger, Chia-Huey Ooi, Derrek P. Hibar, Marta Cañamero, Bruno Gomes, Fabien Gaire, Konstanty Korski
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
The development and progression of solid tumors such as colorectal cancer (CRC) are known to be affected by the immune system and cell types such as T cells, natural killer (NK) cells, and natural killer T (NKT) cells are emerging as interesting targ
Autor:
Christoph B. Geier, Jocelyn R. Farmer, Zsofia Foldvari, Boglarka Ujhazi, Jolanda Steininger, John W. Sleasman, Suhag Parikh, Meredith A. Dilley, Sung-Yun Pai, Lauren Henderson, Melissa Hazen, Benedicte Neven, Despina Moshous, Svetlana O. Sharapova, Snezhina Mihailova, Petya Yankova, Elisaveta Naumova, Seza Özen, Kevin Byram, James Fernandez, Hermann M. Wolf, Martha M. Eibl, Luigi D. Notarangelo, Leonard H. Calabrese, Jolan E. Walter
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Vasculitis can be a life-threatening complication associated with high mortality and morbidity among patients with primary immunodeficiencies (PIDs), including variants of severe and combined immunodeficiencies ((S)CID). Our understanding of vasculit
Autor:
Francesco Sabbatino, Giosuè Scognamiglio, Luigi Liguori, Antonio Marra, Anna Maria Anniciello, Giovanna Polcaro, Jessica Dal Col, Alessandro Caputo, Anna Lucia Peluso, Gerardo Botti, Pio Zeppa, Soldano Ferrone, Stefano Pepe
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Thin melanomas are tumors less than 1 mm thick according to Breslow classification. Their prognosis is in most cases excellent. However, a small subset of these tumors relapses. These clinical findings emphasize the need of novel prognostic biomarker
Autor:
Qitian Mu, Yi Zhang, Xiaoqing Wu, Yongcheng Sun, Yanli Lai, Ping Zhang, Huarui Fu, Zhijuan Xu, Yi Wang, Jiaping Wang, Miao Zhou, Minjie Gao, Ye Sun, Yongxian Hu, Yanli Zhang, Kaihong Xu, Guifang Ouyang, Hao Wu, Binbin Lai, Huiling Zhu, Lixia Sheng, Shujun Yang
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Objectives: The mechanism and immunoregulatory role of human natural killer (NK) cells in acute graft-vs.-host-disease (aGVHD) remains unclear. This study quantitatively analyzed the cytotoxicity of donor NK cells toward allo-reactive T cells, and in