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Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
Background: The primary non-response (PNR) rate of infliximab (IFX) varies from 20 to 46% for the treatment of Crohn’s disease (CD). Detected PNR reduces the improper use of specific treatments. To date, there is hardly any knowledge regarding earl
Autor:
Xiaokang Wang, Chunxiao Ye, Tianrong Xun, Liqian Mo, Yong Tong, Wensi Ni, Suping Huang, Bin Liu, Xia Zhan, Xixiao Yang
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
The antifungal agent voriconazole (VRC) exhibits extreme inter-individual and intra-individual variation in terms of its clinical efficacy and toxicity. Inflammation, as reflected by C-reactive protein (CRP) concentrations, significantly affects the
Autor:
Nenad Neskovic, Dario Mandic, Saska Marczi, Sonja Skiljic, Gordana Kristek, Hrvoje Vinkovic, Boris Mraovic, Zeljko Debeljak, Slavica Kvolik
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Background: Most studies examining tramadol metabolism have been carried out in non-surgical patients and with oral tramadol. The aim of this study was 1) to measure concentrations of tramadol, O-demethyltramadol (ODT), and N-demethyltramadol (NDT) i
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Epilepsy is a devastating neurological condition lacking disease-modifying treatment yet has emerged as a global health concern afflicting around 70 million population globally. The precise understanding of the etiopathology of seizure generation is
Autor:
Juju Shang, Hongxu Liu, Mingxue Zhou, Yue Li, Yanbing Gong, Wen-Long Xing, Xiaomei Qin, Weihong Liu, Mengjie Li, Sinai Li
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Background: Heart failure (HF) is the end stage of ischemic cardiovascular diseases; nonetheless, safe and effective therapeutic agents for HF are still lacking, and their discovery remains challenging. Our previous studies demonstrated that Shen-Yua
Autor:
Amber M. D’Souza, Ashley Cast, Meenasri Kumbaji, Maria Rivas, Ruhi Gulati, Michael Johnston, David Smithrud, James Geller, Nikolai Timchenko
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Objective: Relapsed hepatoblastoma (HBL) and upfront hepatocellular carcinoma (HCC) are notoriously chemoresistant tumors associated with poor outcomes. Gankyrin (Gank) is a known oncogene that is overexpressed in pediatric liver cancer and implicate
Autor:
Jing Wang, Tianshu Liu, Xiongwen Chen, Qiaofeng Jin, Yihan Chen, Li Zhang, Zhengyang Han, Dandan Chen, Yuman Li, Qing Lv, Mingxing Xie
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Myocarditis is a type of inflammatory cardiomyopathy that has no specific treatment. Accumulating evidence suggests that Th17 cells play a prominent role in the pathogenesis of myocarditis. Interleukin-(IL)-6-mediated signal transducer and activation
Autor:
Ba-Wool Lee, Ji-Hye Ha, Yeongseon Ji, Seong-Hun Jeong, Ju-Hong Kim, Jihye Lee, Ji-Young Park, Hyung-Jun Kwon, Kyungsook Jung, Jong-Choon Kim, Young-Bae Ryu, In-Chul Lee
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Alnus hirsuta (Spach) Rupr. (AH), a member of the Betulaceae family, is widely used in Eastern Asia of as a source of medicinal compounds for the treatment of hemorrhage, diarrhea, and alcoholism. In this study, we investigated the protective effects
Autor:
Abdullah-Koolmees, Heshu, van Keulen, Antonius M., Nijenhuis, Marga, Deneer, Vera H.M., Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Frontiers in Pharmacology, 11, 1. Frontiers Media S.A.
Frontiers in pharmacology
Frontiers in Pharmacology
Frontiers in Pharmacology, 11, 1. Frontiers Media S.A.
Frontiers in pharmacology
Frontiers in Pharmacology
Many studies have shown that the efficacy and risk of side effects of drug treatment is influenced by genetic variants. Evidence based guidelines are essential for implementing pharmacogenetic knowledge in daily clinical practice to optimize pharmaco
Autor:
Hongbin Gu, Jia Chen, Mazhong Zhang, Qingquan Lian, Fang Chen, Xingrong Song, Jianmin Zhang, Junzheng Wu, Fang Wang, Li Yang, Yu-Hang Cai, Cheng-Yu Wang, Jun Li, Huacheng Liu
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology, Vol 11 (2020)
Objective: There is no universal agreement on optimal pharmacological regimens for pain management during surgeries. The aim of this study to compare the postoperative analgesic effects of nalbuphine with fentanyl in children undergoing adenotonsille