Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Preclinical research"'
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 14 (2020)
Frontiers in Neuroscience, Vol 14 (2020)
Large number of promising preclinical psychiatric studies in rodents later fail in clinical trials, raising concerns about the efficacy of this approach to generate novel pharmacological interventions. In this mini-review we argue that over-reliance
Autor:
Andrew N. Stewart, Steven M. MacLean, Arnold J. Stromberg, Jessica P. Whelan, William M. Bailey, John C. Gensel, Melinda E. Wilson
Publikováno v:
Frontiers in Neurology
Frontiers in Neurology, Vol 11 (2020)
Frontiers in Neurology, Vol 11 (2020)
In response to NIH initiatives to investigate sex as a biological variable in preclinical animal studies, researchers have increased their focus on male and female differences in neurotrauma. Inclusion of both sexes when modeling neurotrauma is leadi
Publikováno v:
Frontiers in Neuroscience
Shaw, R, Tamagnan, G D & Tavares, A A S 2020, ' Rapidly (and successfully) translating novel brain radiotracers from animal research into clinical use ', Frontiers in Neuroscience . https://doi.org/10.3389/fnins.2020.00871
Frontiers in Neuroscience, Vol 14 (2020)
Shaw, R, Tamagnan, G D & Tavares, A A S 2020, ' Rapidly (and successfully) translating novel brain radiotracers from animal research into clinical use ', Frontiers in Neuroscience . https://doi.org/10.3389/fnins.2020.00871
Frontiers in Neuroscience, Vol 14 (2020)
The advent of preclinical research scanners for in vivo imaging of small animals has added confidence into the multi-step decision-making process of radiotracer discovery and development. Furthermore, it has expanded the utility of imaging techniques
Autor:
Mauricio R. Delgado, Andreas Lysandropoulos, Alberto Esquenazi, Philippe Picaut, Robert A. Hauser, Keith Foster, Jean-Michel Gracies
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Frontiers in Neurology
Frontiers in Neurology
Background: Botulinum toxin-A is a well-established treatment for adult and pediatric spastic paresis and cervical dystonia. While guidelines and approved labels indicate that treatment should not occur more frequently than every 12 weeks, studies an
Publikováno v:
Frontiers in Psychiatry
Frontiers in Psychiatry, Vol 8 (2017)
Frontiers in Psychiatry, Vol 8 (2017)
Preclinical research documents that, aside from the primary and secondary reinforcing effects of nicotine intake itself, nicotine also acutely enhances the reinforcing efficacy of non-drug reinforcers (“rewards”). Study of these effects in humans