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Autor:
Sherry Pierce, Sa A. Wang, Marina Konopleva, Sergej Konoplev, Patrick A. Zweidler-McKay, Hagop M. Kantarjian, Elias Jabbour, Haitham Khogeer, Naval Daver, Joseph D. Khoury, Evgeniya Angelova, Charlene Audette, Jeffrey L. Jorgensen, Yelena Kovtun, L. Jeffrey Medeiros
Publikováno v:
Haematologica
The potential of CD123-targeted therapies in acute lymphoblastic leukemia/lymphoma remains largely unexplored. We examined CD123 expression levels in a large cohort of patients with acute lymphoblastic leukemia/lymphoma and assessed the in vitro impa
Autor:
Lynne V. Abruzzo, George A. Calin, Christopher C. Oakes, Carmen D. Herling, Lynn L. Barron, Haley E. Banks, Michael J. Keating, Vikram Katju, Kevin R. Coombes
Publikováno v:
Haematologica
Although trisomy 12 (+12) chronic lymphocytic leukemia (CLL) comprises about 20% of cases, relatively little is known about its pathophysiology. These cases often demonstrate atypical morphological and immunophenotypic features, high proliferative ra
Autor:
Siham Bibi, Gregor Hoermann, Karoline V. Gleixner, Emir Hadzijusufovic, Peter Bettelheim, Susanne Herndlhofer, Daniela Berger, Andreas Reiter, Peter Valent, Barbara Peter, Wolfgang R. Sperr, Michel Arock, Katharina Blatt, Georg Greiner, Mohamad Jawhar, Gregor Eisenwort, Dubravka Smiljkovic, Mathias Schneeweiss, Gabriele Stefanzl, Klaus Geissler
Publikováno v:
Haematologica
Systemic mastocytosis is a complex disease defined by abnormal growth and accumulation of neoplastic mast cells in various organs. Most patients exhibit a D816V-mutated variant of KIT, which confers resistance against imatinib. Clinical problems in s
Autor:
Manja Meggendorfer, Claudia Haferlach, Niroshan Nadarajah, Sonja Schindela, Torsten Haferlach, Sarah Koch, Constance Baer, Wolfgang Kern
Publikováno v:
Haematologica. 101:830-838
Chronic myeloid leukemia cells acquire resistance to tyrosine kinase inhibitors through mutations in the ABL1 kinase domain. The T315I mutation mediates resistance to imatinib, dasatinib, nilotinib and bosutinib, whereas sensitivity to ponatinib rema
Autor:
Pekka Ellonen, Hanna Rajala, Emma I. Andersson, Satu Mustjoki, Thomas Olson, Thomas P. Loughran, Sonja Lagström, Jesus M. Lopez Marti, Jaroslaw P. Maciejewski, Tuija Lundán, Andres Jerez, Michael J. Clemente, David Hamm, Syed Arshi Uz Zaman, Kimmo Porkka
Publikováno v:
Haematologica. 100:91-99
T-cell large granular lymphocytic leukemia and chronic lymphoproliferative disorder of natural killer cells are intriguing entities between benign and malignant lymphoproliferation. The molecular pathogenesis has partly been uncovered by the recent d
Autor:
Lucía López-Corral, Encarna Fermiñán, Maria Luz Martino, Norma C. Gutiérrez, Luis A. Corchete, Joan Bladé, Maria-Victoria Mateos, Ana Isabel Teruel, Juan José Lahuerta, José Augusto Evangelho Hernandez, Ramón García-Sanz, Albert Oriol, Jesús F. San Miguel, María Eugenia Sarasquete, Francisco J. Burguillo, Jesús M. Hernández-Rivas
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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This is an open-access paper.-- et al.
A multistep model has been proposed of disease progression starting in monoclonal gammopathy of undetermined significance continuing through multiple myeloma, sometimes with an intermediate entity called sm
A multistep model has been proposed of disease progression starting in monoclonal gammopathy of undetermined significance continuing through multiple myeloma, sometimes with an intermediate entity called sm
Autor:
Elena Tibaldi, Renato Zambello, Francesca Zonta, Livio Trentin, Anna Maria Brunati, Federica Frezzato, Veronica Martini, Gianpietro Semenzato, Valentina Trimarco, Cristina Gattazzo, Monica Facco, Monica Castelli
Publikováno v:
Haematologica. 99:1069-1077
Cortactin, an actin binding protein and Lyn substrate, is up-regulated in several cancers and its level is associated with increased cell migration, metastasis and poor prognosis. The identification that the Src kinase Lyn and its substrate HS1 are o
Autor:
Yasunobu Nagata, Chang-Liang Lai, Masashi Sanada, Kenichi Chiba, Satoru Miyano, Yuichi Shiraishi, Seishi Ogawa, Ming-Chung Kuo, Lee-Yung Shih, Hiroko Tanaka, Chein-Fuang Huang, Jin-Hou Wu, Der-Cherng Liang, Tung-Huei Lin, Tung-Liang Lin, En-Hui Lee, Hsiao-Wen Kao, Yu-Shu Shih, Yusuke Okuno
Publikováno v:
Haematologica. 99:28-36
Somatic mutations of TET2, IDH1, and IDH2 have been described in myelodysplastic syndrome. The impact of these mutations on outcome of myelodysplastic syndrome and their progression to secondary acute myeloid leukemia remains unclear. Mutation status
Autor:
Ifigènia Saborit-Villarroya, Marta Aymerich, Mónica López-Guerra, Elias Campo, Laia Rosich, Patricia Pérez-Galán, Silvia Xargay-Torrent, Arnau Montraveta, Dolors Colomer, Gaël Roué, Neus Villamor
Publikováno v:
Haematologica. 98:1739-1747
Phosphatidylinositol-3-kinase pathway is constitutively activated in chronic lymphocytic leukemia mainly due to microenvironment signals, including stromal cell interaction and CXCR4 and B-cell receptor activation. Because of the importance of phosph
Autor:
Vianihuini Figueroa, Antonio Torres-Gomez, S Tabares, Noemi Fernandez-Escalada, Josefina Serrano, Juana Serrano-López, Joaquin Sanchez-Garcia, Javier Casaño
Publikováno v:
Haematologica. 98:1877-1885
Survivin is over-expressed in most hematologic malignancies but the prognostic significance of the subcompartmental distribution of wild-type or splicing variants in acute myeloid leukemia has not been addressed yet. Using western blotting, we assess