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Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51
Autor:
Yukiko Tomioka, Katsumi Mominoki, Kazuhiko Ochiai, Toshina Oonuma, Toshinori Omi, Eichi Takeda, Kazuyoshi Hashizume, Jiro Arikawa, Masami Morimatsu, Kumiko Yoshimatsu, Yasunaga Yoshikawa
Publikováno v:
FEBS Letters. (12):1771-1777
The breast cancer susceptibility protein BRCA2 is essential for recombinational DNA repair. BRCA2 specifically binds to RAD51 via eight BRC repeat motifs and delivers RAD51 to double-stranded DNA breaks. In this study, a mammalian two-hybrid assay an