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Autor:
Jyrki P. Kukkonen, Lisa Johansson, Johnny Näsman, Jaana Putula, Laura Korhonen, Runar Ra, Pauli M. Turunen
Publikováno v:
FEBS Letters. (9):1368-1374
We wanted to analyze the basis for the distinction between OX(1) and OX(2) orexin receptors by the known agonists, orexin-A, orexin-B and Ala(11), D-Leu(15)-orexin-B, of which the latter two show some selectivity for OX(2). For this, chimaeric OX(1)/
Publikováno v:
FEBS Letters. (1):13-16
The number of dihydropyridine receptors (DHPR) and sarcoplasmic reticulum (SR) Ca2+ release channels (RyR1) and their interaction determine the efficacy of the sarcolemmal excitation-SR Ca2+ release-contraction coupling (ECC). Both receptors play a c
Autor:
Lennart Zabeau, Delphine Lavens, Joël Vandekerckhove, Jan Tavernier, Frank Peelman, Sven Eyckerman
Publikováno v:
FEBS Letters. (1):45-50
The adipocyte-derived hormone leptin signals the status of body energy stores by activating its receptor in hypothalamic nuclei. In contrast to the initial expectations, leptin treatment of human obesity was largely unsuccessful. One explanation for
Publikováno v:
FEBS Letters. (2-3):187-190
Corticotropin releasing factor (CRF) induces a rapid, within seconds, and dose-dependent increase in the intracellular Ca2+ in both human and hamster melanoma cells. This effect is inhibited by depletion of extracellular calcium using 3 mM EGTA and i
Autor:
Hui Zhou, Mianbo Huang, Li-Ming Ma, Liang-Hu Qu, Huilin Huang, Peng Shao, Bin Du, Yue-Qin Chen
Publikováno v:
FEBS Letters. (4):811-816
Deposition of collagen IV in proximal tubule cells (PTCs) plays an important role during diabetic nephropathy, but the mechanism underlying excessive production of collagen IV remains poorly understood. In this study, we examined the miRNA profile of
Publikováno v:
FEBS Letters. (1):142-151
In this review, we present evidence from human and animal studies to evaluate the hypothesis that sleep and circadian rhythms have direct impacts on energy metabolism, and represent important mechanisms underlying the major health epidemics of obesit
Autor:
Takahiro Abe, Mikako Degawa-Yamauchi, Hironaga Kuwahara, Hironori Yamasaki, Yoshihiko Yamaguchi, Katsumi Eguchi, Shigeo Uotani, Ryoko Takahashi
Publikováno v:
FEBS Letters. (1-3):116-120
Leptin, an adipocyte-derived hormone, regulates food intake and energy expenditure in the hypothalamus via its receptor, member of the class I cytokine receptor family. Leptin resistance has been observed in rodents and in humans. However, the mechan
Autor:
Yoshiharu Saito, Masahiko Endo, Keiichi Takagaki, Toshiya Nakamura, Kanji Tanaka, Masaru Funahashi
Publikováno v:
FEBS Letters. (2-3):223-226
The effects of progesterone, dehydroepiandrosterone sulfate and 17β-estradiol on the synthesis and degradation of hyaluronate were investigated using human uterine cervix fibroblasts. The cells were incubated with [3H]glucosamine in the presence of
Publikováno v:
FEBS Letters. (9):1856-1863
Alzheimer’s disease (AD) is one of the most devastating diseases of the central nervous system (CNS). It is characterized by two neuropathological findings: amyloid plaques and neurofibrillary tangles. AD is also accompanied by an extensive functio
Publikováno v:
FEBS Letters. (1):83-87
Mouse EC cell line ATDC5 undergoes differentiation to form cartilage nodules via the cellular condensation stage in the presence of insulin. ATDC5 cells expressed transcripts for bone morphogenetic protein-4 (BMP-4), and type IA and type II BMP recep