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Publikováno v:
FEBS Letters. (2-3):187-190
Corticotropin releasing factor (CRF) induces a rapid, within seconds, and dose-dependent increase in the intracellular Ca2+ in both human and hamster melanoma cells. This effect is inhibited by depletion of extracellular calcium using 3 mM EGTA and i
Autor:
Takahiro Abe, Mikako Degawa-Yamauchi, Hironaga Kuwahara, Hironori Yamasaki, Yoshihiko Yamaguchi, Katsumi Eguchi, Shigeo Uotani, Ryoko Takahashi
Publikováno v:
FEBS Letters. (1-3):116-120
Leptin, an adipocyte-derived hormone, regulates food intake and energy expenditure in the hypothalamus via its receptor, member of the class I cytokine receptor family. Leptin resistance has been observed in rodents and in humans. However, the mechan
Autor:
Hui Xu, Akihide Tanimoto, Yasuyuki Sasaguri, Yoshitaka Murata, Masako Nomaguchi, Tetsuo Hamada, Nobuyuki Arima, Satoshi Kimura
Publikováno v:
FEBS Letters. (3):345-349
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a member of the scavenger receptor family, and is known to be expressed in monocytes/macrophages. We investigated the effect of histamine on the expression of LOX-1 in cells of the hu
Publikováno v:
FEBS Letters. (1-2):25-29
Progesterone at concentrations between 10 microM and 200 microM affected the calcium signaling evoked by ligand stimulation of G protein-coupled receptors expressed in several cell lines. At 160 microM progesterone the signaling of all receptors was
Publikováno v:
FEBS Letters. (3):215-218
The NCI-H292 cell, a human pulmonary mucoepidermoid carcinoma cell line, is commonly used for studying bacterial and viral infections of airway epithelial cells. Dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) is the mai
Autor:
Isabelle Lamarche, Françoise Bono, P. Savi, Jean-Marc Herbert, Giuliano Della Valle, Josette Bornia
Publikováno v:
FEBS Letters. (1):93-97
Nerve growth factor (NGF), the prototypic member of the neurotrophin family of growth factors, exerts its action via two receptors, P75NTR and TrkA, the expression of which varies at the cell surface of neuroblastoma cells (SH-SY5Y cells) in a cycle
Publikováno v:
FEBS Letters. (3):266-271
Zinc (Zn) deficiency is often associated with low plasma vitamin A (retinol) concentrations. It has been suggested that the reduction in plasma retinol is secondary to reduced liver retinol binding protein (RBP) synthesis. In the present study, RBP e
Publikováno v:
FEBS Letters. (1-2):109-112
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental toxin that activates the aryl hydrocarbon receptor (AhR) and disrupts multiple endocrine signaling pathways. T47D human breast cancer cells express a functional estrogen receptor alpha (E
Autor:
Graciela Castro, Laurent Vergnes, Mario M. Zakin, Alberto Ochoa, Maria A. Ostos, Nadine Baroukh, Delia Recalde, Jean-Charles Fruchart, Bart Staels
Publikováno v:
FEBS Letters. (1-2):16-20
We have previously generated transgenic (Tg) mice expressing the human apolipoprotein (apo) A-I/C-III/A-IV gene cluster. This expression induced hyperlipidemia but reduced atherosclerotic lesions in genetically modified mice lacking apoE. Atheroscler
Estrogen withdrawal-induced human breast cancer tumour regression in nude mice is prevented by Bcl-2
Autor:
Heather Macleod, Michel Ménard, M.A. Christine Pratt, Stanislaw Krajewski, Maryla Krajewska, John C. Reed
Publikováno v:
FEBS Letters. (3):403-408
We recently showed that estrogen induces expression of the anti-apoptotic protein, Bcl-2 in MCF-7 human breast cancer cells. Since estrogen-dependent breast tumours can regress following estrogen withdrawal, we hypothesized that stable Bcl-2 expressi