Zobrazeno 1 - 10
of 25
pro vyhledávání: '"11"'
Autor:
Nikhil Hirani, Robert J. Slack, Hans Thalsgaard Schambye, Duncan Humphries, A. John Simpson, Ian Forrest, Fredrik Zetterberg, Lucy Keeling, Michael A Gibbons, Wendy Funston, Paul Ford, Toby M. Maher, Ulf J. Nilsson, Tariq Sethi, Anders Pedersen, Lyn Paul, Philip L. Molyneaux, Ross Mills, Alison C. MacKinnon, Hakon Leffler, Lise Gravelle, Lisa Nicol, Feng Li, Susan Tantawi, Utsa Karmakar
Galectin (Gal)-3 is a profibrotic β-galactoside-binding lectin that plays a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF exacerbations. TD139 is a novel and potent small-molecule inhibitor of Gal-3.A randomised, double
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4821d3d0249b9f434433b15c5cc88fd
http://hdl.handle.net/10044/1/85036
http://hdl.handle.net/10044/1/85036
Publikováno v:
Molecular Pathology and Functional Genomics.
Introduction: Polymorphisms of inducible nitric oxide synthase (NOS2) gene is related to fractional exhaled nitric oxide (FeNO) level in steroid-naive patients with asthma, but its association with treatment outcomes remains unclear. Aims and objecti
Autor:
Sara Yubero, Elvira Gonzalez-Obeso, Ramon Farré, Teresa Gallego-Martin, Elena Olea, Ana Obeso, Constancio Gonzalez
Publikováno v:
4.2 Sleep and Control of Breathing.
Background: Recent studies have reported, albeit with discrepancies, an association between severity of OSA and cancer incidence/mortality. Discrepancies are likely due to the large number of OSA-linked comorbidities and uncontrolled variables among
Autor:
Ana Antunes, Daniel Coutinho, Sara Conde, Ana Barroso, Sérgio Campainha, Rita Linhas, Margarida Dias
Publikováno v:
11.1 Lung Cancer.
Introduction: Staging of lung cancer is an important predictor of survival. The last review of the TNM staging divides the M1 descriptor into M1a (pulmonary contralateral metastases or pleural/pericardial effusion) and M1b (extrapulmonary metastases)
Autor:
James Markos, Heinrich C. Weber, Samuel James Brake, Josie Larby, Mathew Suji Eapen, Greg Haug, Peter A. B. Wark, Wenying Lu, Surajit Dey, Archana Vijay Gaikwad, Stephen Myers, Prem Bhattarai, Collin Chia, Sukhwinder Singh Sohal
Publikováno v:
Molecular pathology and functional genomics.
Background: Management of ACO is clinically challenging due to insufficient evidence on pathological changes in these patients. Aim: To evaluate large airway remodelling changes in patients with ACO compared to asthma, COPD ex-smokers (ES) and curren
Autor:
Alejandro Sanchez-Crespo, Magnus Svartengren, Maria Diakopoulou, Martin Anderson, Mikaela Qvarfordt
Publikováno v:
Occupational and environmental health.
There is a link between acute elevated air pollution levels and adverse health effects. One explanation could be translocation of particles deposited in the lungs into the blood stream. In the present study we studied particle translocation from lung
Autor:
Nikolaos Lazarinis, Craig E. Wheelock, Apostolos Bossios, Alessandro Quaranta, Javier Zurita, Sven-Erik Dahlén, Valentyna Yasinska, Johan Kolmert, Barbro Dahlén
Publikováno v:
Allergy and immunology.
Background: Urinary metabolites of cysteinyl-leukotrienes (CysLTs) and prostaglandin (PG) D2 are increased in type 2 asthma. The eosinophil is one source of the CysLTs, whereas most PGD2 is biosynthesised in mast cells. It is not known if treatment w
Autor:
Nagehan Emiralioglu, Ugur Ozcelik, Dilber Ademhan, Berna Oguz, Nural Kiper, Deniz Dogru, Beste Ozsezen, Birce Sunman, Ebru Yalcin
Publikováno v:
Paediatric bronchology.
Background and Aim: Primary ciliary dyskinesia(PCD) is a genetic disorder characterized by heterogeneous airway disease.Diagnostic delay and recurrent lung infections are the main reason of bronchiectasis in these children.However children with PCD h
Autor:
Yuki Sato, Yusuke Shima, Kazutaka Hosoya, Yuri Shimada, Atsushi Nakagawa, Keisuke Tomii, Ryosuke Hirabayashi, Atsushi Matsunashi, Kazuma Nagata, Megumu Osaki, Ryo Tachikawa
Publikováno v:
Acute critical care.
Background: Serum levels of KL-6 are useful biomarkers for diagnosis of interstitial lung diseases (ILDs). However, its diagnostic utility in the setting of acute respiratory failure (ARF) is unknown. Aims and Objectives: We investigated how high ser
Autor:
C. Magnus Sköld, Benedikt Zöhrer, Anna James, Åsa M. Wheelock, Nabil Souihi, Bettina Brundin, SE Dahlen, David J. Erle, Reza Karimi
Publikováno v:
Monitoring airway disease.
Background: The protein YKL-40 (CHI3L1) is associated with smoking and chronic obstructive pulmonary disease (COPD). Smoking is a major risk factor for COPD, and the importance of gender on molecular COPD sub-phenotypes is emerging. Aims and Objectiv