Zobrazeno 1 - 10
of 24
pro vyhledávání: '"11"'
Autor:
Andrew S. Cowburn, Shanhai Xie, David Macías, Alexander J.T. Wood, Stephen Moore, Alexi Crosby, Xinlin Du, Wallace Eli M, Arlette Vassallo, Mark Southwood, Huiling Tan
Publikováno v:
The European Respiratory Journal
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart failure and death. Current therapeutic intervention strategies only slow disease progression. The role of aberrant hypoxia-induci
Autor:
Nikhil Hirani, Robert J. Slack, Hans Thalsgaard Schambye, Duncan Humphries, A. John Simpson, Ian Forrest, Fredrik Zetterberg, Lucy Keeling, Michael A Gibbons, Wendy Funston, Paul Ford, Toby M. Maher, Ulf J. Nilsson, Tariq Sethi, Anders Pedersen, Lyn Paul, Philip L. Molyneaux, Ross Mills, Alison C. MacKinnon, Hakon Leffler, Lise Gravelle, Lisa Nicol, Feng Li, Susan Tantawi, Utsa Karmakar
Galectin (Gal)-3 is a profibrotic β-galactoside-binding lectin that plays a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF exacerbations. TD139 is a novel and potent small-molecule inhibitor of Gal-3.A randomised, double
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4821d3d0249b9f434433b15c5cc88fd
http://hdl.handle.net/10044/1/85036
http://hdl.handle.net/10044/1/85036
Autor:
Rozsa Schlenker-Herceg, Emmanuelle Clerisme-Beaty, Victor J. Thannickal, Simon L.F. Walsh, Kay Tetzlaff, Vincent Cottin, Antje Prasse, Fernando J. Martinez, Kevin K. Brown, Athol U. Wells, Rainer-Georg Goeldner
Publikováno v:
The European Respiratory Journal
article-version (VoR) Version of Record
article-version (VoR) Version of Record
We used data from the INBUILD and INPULSIS trials to investigate the natural history of progressive fibrosing interstitial lung diseases (ILDs). Subjects in the two INPULSIS trials had a clinical diagnosis of idiopathic pulmonary fibrosis (IPF) while
Autor:
Aaron Spivak, Ruth Tal-Singer, Sebastian L. Johnston, David L. Mayhew, Mohammadali Yavari Ramsheh, Zhang Wang, Mona Bafadhel, James R. Brown, Bruce E. Miller, Christopher E. Brightling, Koirobi Haldar, Michael R. Barer
Increasing evidence suggests that the lung microbiome plays an important role in chronic obstructive pulmonary disease (COPD) severity. However, the dynamics of the lung microbiome during COPD exacerbations and its potential role in disease aetiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a33fc7e5ba4fe96b3c4b07a71ff0b5
https://ora.ox.ac.uk/objects/uuid:d919d8a7-bfbd-4dc7-b67a-264640d967df
https://ora.ox.ac.uk/objects/uuid:d919d8a7-bfbd-4dc7-b67a-264640d967df
Autor:
Prasad Nagakumar, Louise Fleming, Franz Puttur, Andrew Bush, Sejal Saglani, Clare M. Lloyd, Lisa G. Gregory, Laura Denney
Publikováno v:
The European Respiratory Journal
Children with severe therapy-resistant asthma (STRA) have poor control despite maximal treatment, while those with difficult asthma (DA) have poor control from failure to implement basic management, including adherence to therapy. Although recognised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848202dd65af430233afb0454d0ad459
http://hdl.handle.net/10044/1/70799
http://hdl.handle.net/10044/1/70799
Autor:
Francois Ng Kee Kwong, Bertrand De Meulder, Julie Corfield, Peter J. Sterk, Uruj Hoda, Ian M. Adcock, Pascal Chanez, F. Baribaud, Ana R. Sousa, Kai Sun, Steve J. Fowler, Matthew J. Loza, Richard G. Knowles, Louise Fleming, Stelios Pavlidis, Kian Fan Chung, Kentaro Takahashi, Jiaxing Xie, Yike Guo, V. Elyasigomari, Peter H. Howarth, Paul-Michael Agapow, Charles Auffray, Dominic E. Shaw, Ratko Djukanovic
Publikováno v:
European respiratory journal, 53(1):1800938. European Respiratory Society
U-BIOPRED Study Group 2019, ' “T2-high” in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin ', European Respiratory Journal, vol. 53, no. 1, 1800938 . https://doi.org/10.1183/13993003.00938-2018
U-BIOPRED Study Group 2019, ' “T2-high” in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin ', European Respiratory Journal, vol. 53, no. 1, 1800938 . https://doi.org/10.1183/13993003.00938-2018
Type-2 (T2) immune responses in airway epithelial cells (AECs) classifies mild–moderate asthma into a T2-high phenotype. We examined whether currently available clinical biomarkers can predict AEC-defined T2-high phenotype within the U-BIOPRED coho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dca3566e93a10fa57168a2e8a1ec00
http://hdl.handle.net/10044/1/65419
http://hdl.handle.net/10044/1/65419
Many common airway diseases are characterised by chronic symptoms with interspersed acute and unpredictable deteriorations, conventionally called “pulmonary exacerbations”. Until relatively recently, these so-called exacerbations were a rather Ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2869d94b0788fef131e20a595604f9e7
http://hdl.handle.net/10044/1/43408
http://hdl.handle.net/10044/1/43408
Autor:
Harry B. Rossiter, Merry-Lynn McDonald, William W. Stringer, Alessandra Adami, Edwin K. Silverman, Janos Porszasz, Brian D. Hobbs, Michael H. Cho, Richard Casaburi
Publikováno v:
Clinical Respiratory Physiology, Exercise and Functional Imaging.
Introduction: Low aerobic capacity is a strong mortality risk factor. A large fraction of variance in aerobic capacity gained by exercise training is accounted for by 11 single nucleotide polymorphisms (SNPs; Timmons et al. PMC2886694). COPD is assoc
Autor:
Lauranne Schoneveld, Julien Guiot, Etienne Cavalier, Michel Moutschen, Anne Noelle Frix, Benoit Misset, Bernard Duysinx, Renaud Louis, F Vaillant, Monique Henket, Aurélie Ladang
Publikováno v:
Respiratory Research
Background Coronavirus disease COVID-19 has become a public health emergency of international concern. Together with the quest for an effective treatment, the question of the post-infectious evolution of affected patients in healing process remains u
Autor:
Donato Lacedonia, Giulia Scioscia, Angelamaria Giardinelli, Maria Pia Foschino Barbaro, Ernesto Giuffreda, Carla Maria Irene Quarato, Pasquale Tondo, Marco Sperandeo, Federica Maci
Publikováno v:
Ultrasound.
Background: High-resolution computed tomography (HRCT) is the gold standard in the diagnosis and follow-up of interstitial lung diseases (ILDs), however it is associated with high radiation exposure. Aim of the study: Since Transthoracic Ultrasound (