Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Shingo Kajimura"'
Autor:
Vanille J. Greiner, Michael T. McManus, Shingo Kajimura, Rachana N. Pradhan, Suneil K. Koliwad, Kazuki Tajima, Zachary Brown, Rachel T. Cheang, Bruce M. Spiegelman, Takeshi Yoneshiro, Ritwik Datta, Kamran Atabai, Christopher D Yang, Qiang Wang, Hyeonwoo Kim, Diana L. Alba, Kosaku Shinoda, Caroline R. Kim, Yasuo Oguri, W. Reid Bolus, Kazuyuki Tsujino, Yong Chen, Kenji Ikeda
Publikováno v:
Cell, vol 182, iss 3
Adipose tissues dynamically remodel their cellular composition in response to external cues by stimulating beige adipocyte biogenesis; however, the developmental origin and pathways regulating this process remain insufficiently understood owing to ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91c20ee817bee8df20e47803951f57b
https://escholarship.org/uc/item/1fb2d4gg
https://escholarship.org/uc/item/1fb2d4gg
Autor:
Ella A. Thomson, Marc Ferro, Shingo Kajimura, Kazuki Tajima, Yasuo Oguri, Kenji Ikeda, Yuji Tanabe, Ada S. Y. Poon, Takeshi Yoneshiro
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications, vol 11, iss 1
Cold stimuli and the subsequent activation of β-adrenergic receptor (β-AR) potently stimulate adipose tissue thermogenesis and increase whole-body energy expenditure. However, systemic activation of the β3-AR pathway inevitably increases blood pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254eeb35c8356ae40d20367bdbbadcfb
https://escholarship.org/uc/item/6rx3x2c0
https://escholarship.org/uc/item/6rx3x2c0
Autor:
Yangyu Yang, Qianqian Kang, Shingo Kajimura, Svetlana Altshuler-Keylin, Yutaka Hasegawa, Kenji Ikeda, Haemin Hong, Kosaku Shinoda, Jayanta Debnath, Rushika M. Perera
Publikováno v:
Cell metabolism, vol 24, iss 3
Altshuler-Keylin, S; Shinoda, K; Hasegawa, Y; Ikeda, K; Hong, H; Kang, Q; et al.(2016). Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. CELL METABOLISM, 24(3), 402-419. doi: 10.1016/j.cmet.2016.08.002. UCSF: Retrieved from: http://www.escholarship.org/uc/item/661318hx
Altshuler-Keylin, S; Shinoda, K; Hasegawa, Y; Ikeda, K; Hong, H; Kang, Q; et al.(2016). Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. CELL METABOLISM, 24(3), 402-419. doi: 10.1016/j.cmet.2016.08.002. UCSF: Retrieved from: http://www.escholarship.org/uc/item/661318hx
Beige adipocytes gained much attention as an alternative cellular target in anti-obesity therapy. While recent studies have identified a number of regulatory circuits that promote beige adipocyte differentiation, the molecular basis of beige adipocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebccb291f544745a439a0713f0bbafc
https://escholarship.org/uc/item/661318hx
https://escholarship.org/uc/item/661318hx
Publikováno v:
Nature reviews. Molecular cell biology, vol 17, iss 8
Inagaki, T; Sakai, J; & Kajimura, S. (2016). Transcriptional and epigenetic control of brown and beige adipose cell fate and function. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 17(8), 480-495. doi: 10.1038/nrm.2016.62. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1nj100m1
Inagaki, T; Sakai, J; & Kajimura, S. (2016). Transcriptional and epigenetic control of brown and beige adipose cell fate and function. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 17(8), 480-495. doi: 10.1038/nrm.2016.62. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1nj100m1
White adipocytes store excess energy in the form of triglycerides, whereas brown and beige adipocytes dissipate energy in the form of heat. This thermogenic function relies on the activation of brown and beige adipocyte-specific gene programmes that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbcf52c3d5d36786ed260ceb82208ccd
https://escholarship.org/uc/item/1nj100m1
https://escholarship.org/uc/item/1nj100m1
Autor:
Maria Chondronikola, Miae Kim, Yutaka Hasegawa, Jan Nedergaard, Yu-Hua Tseng, Aaron M. Cypess, Si Brask Sonne, Labros S. Sidossis, Ruidan Xue, Kosaku Shinoda, Shingo Kajimura, Ineke H.N. Luijten, Haemin Hong
Publikováno v:
Nature Medicine, vol 21, iss 4
Nature medicine, vol 21, iss 4
Shinoda, K; Luijten, IHN; Hasegawa, Y; Hong, H; Sonne, SB; Kim, M; et al.(2015). Genetic and functional characterization of clonally derived adult human brown adipocytes. Nature Medicine, 21(4), 389-394. doi: 10.1038/nm.3819. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4qk4m480
Nature medicine, vol 21, iss 4
Shinoda, K; Luijten, IHN; Hasegawa, Y; Hong, H; Sonne, SB; Kim, M; et al.(2015). Genetic and functional characterization of clonally derived adult human brown adipocytes. Nature Medicine, 21(4), 389-394. doi: 10.1038/nm.3819. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4qk4m480
©2005 Nature America, Inc. All rights reserved. Brown adipose tissue (BAT) acts in mammals as a natural defense system against hypothermia, and its activation to a state of increased energy expenditure is believed to protect against the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6aedfa68cd900c775d7536683121e4
https://escholarship.org/uc/item/4qk4m480
https://escholarship.org/uc/item/4qk4m480
Autor:
Shingo Kajimura, Masayuki Saito
Publikováno v:
Annual review of physiology, vol 76, iss 1
Kajimura, S; & Saito, M. (2014). A new era in brown adipose tissue biology: Molecular control of brown fat development and energy homeostasis. Annual Review of Physiology, 76, 225-249. doi: 10.1146/annurev-physiol-021113-170252. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/61v5z1v2
Kajimura, S; & Saito, M. (2014). A new era in brown adipose tissue biology: Molecular control of brown fat development and energy homeostasis. Annual Review of Physiology, 76, 225-249. doi: 10.1146/annurev-physiol-021113-170252. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/61v5z1v2
Brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat as a defense against cold and excessive feeding. Interest in the field of BAT biology has exploded in the past few years because of the therapeutic potential o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733dfe70950be7f7e02415ccb52def73
https://escholarship.org/uc/item/61v5z1v2
https://escholarship.org/uc/item/61v5z1v2
Publikováno v:
Kajimura, Shingo; Ohno, H; Shinoda, K; Ohyama, K; & Sharp, LZ. (2013). EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3nx7b8nd
Nature
Nature
Brown adipose tissue-enriched lysine methyltransferase EHMT1 is an essential enzyme in the PRDM16–C/EBP-β transcriptional complex that controls brown adipose cell fate and energy metabolism. Here it is shown that euchromatic histone-lysine N-methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab14e9ce6db31c18d7035f5d840b2002
http://www.escholarship.org/uc/item/3nx7b8nd
http://www.escholarship.org/uc/item/3nx7b8nd
Publikováno v:
Kajimura, Shingo; Gilsanz, V; & Hu, HH. (2013). Relevance of brown adipose tissue in infancy and adolescence. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/24d3j68t
Pediatric research
Pediatric research
Brown adipose tissue (BAT) was thought to disappear after infancy. Recent studies finding BAT in patients undergoing positron emission tomography/computed tomography (PET/CT) have renewed the interest in deciphering the relevance of this tissue in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9aaba0649b6ddfc3512017074fe217b
http://www.escholarship.org/uc/item/24d3j68t
http://www.escholarship.org/uc/item/24d3j68t