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Autor:
Laurynne C. Coates, Sierra D. Durham, David H. Storms, Andrew D. Magnuson, Diane L. Van Hekken, Benjamin M. Plumier, John W. Finley, Naomi K. Fukagawa, Peggy M. Tomasula, Danielle G. Lemay, Matthew J. Picklo, Daniela Barile, Kenneth F. Kalscheur, Mary E. Kable
Publikováno v:
Microbiology spectrum, vol 11, iss 3
Milk oligosaccharides (MOs) can be prebiotic and antiadhesive, while fatty acids (MFAs) can be antimicrobial. Both have been associated with milk microbes or mammary gland inflammation in humans. Relationships between these milk components and milk m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c28bffd65fa0e65e9a0bea3a737b378
https://escholarship.org/uc/item/24d562fv
https://escholarship.org/uc/item/24d562fv
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus
Autor:
Albertas Navickas, Hosseinali Asgharian, Juliane Winkler, Lisa Fish, Kristle Garcia, Daniel Markett, Martin Dodel, Bruce Culbertson, Sohit Miglani, Tanvi Joshi, Keyi Yin, Phi Nguyen, Steven Zhang, Nicholas Stevers, Hun-Way Hwang, Faraz Mardakheh, Andrei Goga, Hani Goodarzi
Publikováno v:
Nature cell biology, vol 25, iss 6
Cancer cells often co-opt post-transcriptional regulatory mechanisms to achieve pathologic expression of gene networks that drive metastasis. Translational control is a major regulatory hub in oncogenesis; however, its effects on cancer progression r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba97ac6204b87cfd1b8c286a7d951fc
https://escholarship.org/uc/item/0rw7759t
https://escholarship.org/uc/item/0rw7759t
Publikováno v:
The Journal of biological chemistry, vol 299, iss 6
Journal of Biological Chemistry, 299(6):104771. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry, 299(6)
Journal of Biological Chemistry, 299(6):104771. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry, 299(6)
Genetically encoded voltage indicators, particularly those based on microbial rhodopsins, are gaining traction in neuroscience as fluorescent sensors for imaging voltage dynamics with high-spatiotemporal precision. Here we establish a novel genetical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa444654a3f5e13d75f66dd3c852f17
https://escholarship.org/uc/item/4sv4x15j
https://escholarship.org/uc/item/4sv4x15j
Pompe disease is an autosomal recessive lysosomal storage disease caused by pathogenic variants in GAA, which encodes an enzyme integral to glycogen catabolism, acid α-glucosidase. Disease-relevant cell lines are necessary to evaluate the efficacy o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674f754760e8b128a21849e99b836d3a
https://escholarship.org/uc/item/4ds0566v
https://escholarship.org/uc/item/4ds0566v
Autor:
Jacob Folz, Rebecca Neal Culver, Juan Montes Morales, Jessica Grembi, George Triadafilopoulos, David A. Relman, Kerwyn Casey Huang, Dari Shalon, Oliver Fiehn
Publikováno v:
Nature metabolism, vol 5, iss 5
Most processing of the human diet occurs in the small intestine. Metabolites in the small intestine originate from host secretions, plus the ingested exposome1 and microbial transformations. Here we probe the spatiotemporal variation of upper intesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becbfaead4a37936a8fda43b29f18c32
https://escholarship.org/uc/item/8kq2w6q8
https://escholarship.org/uc/item/8kq2w6q8
Autor:
Cale O. Seymour, Marike Palmer, Eric D. Becraft, Ramunas Stepanauskas, Ariel D. Friel, Frederik Schulz, Tanja Woyke, Emiley Eloe-Fadrosh, Dengxun Lai, Jian-Yu Jiao, Zheng-Shuang Hua, Lan Liu, Zheng-Han Lian, Wen-Jun Li, Maria Chuvochina, Brianna K. Finley, Benjamin J. Koch, Egbert Schwartz, Paul Dijkstra, Duane P. Moser, Bruce A. Hungate, Brian P. Hedlund
Publikováno v:
Nature microbiology, vol 8, iss 4
Candidate bacterial phylum Omnitrophota has not been isolated and is poorly understood. We analysed 72 newly sequenced and 349 existing Omnitrophota genomes representing 6 classes and 276 species, along with Earth Microbiome Project data to evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f86d5ff43222c2ea2e1dd00846d7475
https://escholarship.org/uc/item/1fd9s2sg
https://escholarship.org/uc/item/1fd9s2sg
Publikováno v:
Autophagy, vol 19, iss 4
Macroautophagy/autophagy is a multistep degradative process that is essential for maintaining cellular homeostasis and is often dysregulated during disease. Systematically quantifying flux through this pathway is critical for gaining fundamental insi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93340447e88fbdc96900827c6ba4a778
https://escholarship.org/uc/item/4268m50q
https://escholarship.org/uc/item/4268m50q
Autor:
Jorgelina M. Calandria, Khanh V. Do, Sayantani Kala-Bhattacharjee, Andre Obenaus, Ludmila Belayev, Nicolas G. Bazan
Publikováno v:
Cellular and molecular neurobiology, vol 43, iss 3
Abstract Wnt5a triggers inflammatory responses and damage via NFkB/p65 in retinal pigment epithelial (RPE) cells undergoing uncompensated oxidative stress (UOS) and in experimental ischemic stroke. We found that Wnt5a-Clathrin-mediated uptake leads t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e5591ddae6f07ef5f78ed4fb1753e5
https://escholarship.org/uc/item/0d0386cv
https://escholarship.org/uc/item/0d0386cv
Autor:
Yu-Tzu Chan, Ruey-Jen Lin, Ya-Hui Wang, Tsai-Hsien Hung, Yenlin Huang, John Yu, Jyh-Cherng Yu, Alice L. Yu
Publikováno v:
Cell communication and signaling : CCS, vol 21, iss 1
Background Both IGF-1R/PI3K/AKT/mTOR and Hippo pathways are crucial for breast cancer stem cells (BCSCs). However, their interplay remains unclear. Methods Four triple negative breast cancer cell lines derived from CSC of two patient-derived xenograf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504eaf0c6473ef08c63c3382665c8d1a
https://escholarship.org/uc/item/4fm6220w
https://escholarship.org/uc/item/4fm6220w
Autor:
Mohamad Dandan, Julia Han, Sabrina Mann, Rachael Kim, Kelvin Li, Hussein Mohammed, Jen-Chieh Chuang, Kaiyi Zhu, Andrew N. Billin, Ryan S. Huss, Chuhan Chung, Robert P. Myers, Marc Hellerstein
Publikováno v:
Journal of lipid research, vol 64, iss 3
Treatment with acetyl-CoA carboxylase inhibitors (ACCi) in nonalcoholic steatohepatitis (NASH) may increase plasma triglycerides (TGs), with variable changes in apoB concentrations. ACC is rate limiting in de novo lipogenesis and regulates fatty acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fec174143a6c6349df261609d93d11
https://escholarship.org/uc/item/4pt41456
https://escholarship.org/uc/item/4pt41456