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Pompe disease is an autosomal recessive lysosomal storage disease caused by pathogenic variants in GAA, which encodes an enzyme integral to glycogen catabolism, acid α-glucosidase. Disease-relevant cell lines are necessary to evaluate the efficacy o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674f754760e8b128a21849e99b836d3a
https://escholarship.org/uc/item/4ds0566v
https://escholarship.org/uc/item/4ds0566v
Autor:
Yu-Tzu Chan, Ruey-Jen Lin, Ya-Hui Wang, Tsai-Hsien Hung, Yenlin Huang, John Yu, Jyh-Cherng Yu, Alice L. Yu
Publikováno v:
Cell communication and signaling : CCS, vol 21, iss 1
Background Both IGF-1R/PI3K/AKT/mTOR and Hippo pathways are crucial for breast cancer stem cells (BCSCs). However, their interplay remains unclear. Methods Four triple negative breast cancer cell lines derived from CSC of two patient-derived xenograf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504eaf0c6473ef08c63c3382665c8d1a
https://escholarship.org/uc/item/4fm6220w
https://escholarship.org/uc/item/4fm6220w
Publikováno v:
Stem cells (Dayton, Ohio), vol 41, iss 2
Human induced pluripotent stem cell (iPSC)-derived liver organoids serve as models of organogenesis, disease, drug screening, and regenerative medicine. Prevailing methods for generating organoids rely on Matrigel, whose batch-to-batch variability an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2e7afb3de3b6a21f433c78603a2437
https://escholarship.org/uc/item/7r84892g
https://escholarship.org/uc/item/7r84892g
Autor:
Chengsheng Wu, Taha Rakhshandehroo, Hiromi I. Wettersten, Alejandro Campos, Tami von Schalscha, Shashi Jain, Ziqi Yu, Jiali Tan, Evangeline Mose, Betzaira G. Childers, Andrew M. Lowy, Sara M. Weis, David A. Cheresh
Publikováno v:
Nature cell biology, vol 25, iss 2
Nat Cell Biol
Nat Cell Biol
Defining drivers of tumour initiation can provide opportunities to control cancer progression. Here we report that lysophosphatidic acid receptor 4 (LPAR4) becomes transiently upregulated on pancreatic cancer cells exposed to environmental stress or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7183f74989b8a5e50b8abbec1e8ef4a
https://escholarship.org/uc/item/3xs321vw
https://escholarship.org/uc/item/3xs321vw
Autor:
Shenjie Wu, Nancy C Hernandez Villegas, Daniel W Sirkis, Iona Thomas-Wright, Richard Wade-Martins, Randy Schekman
Alpha-synuclein (α-syn), a major component of Lewy bodies found in Parkinson’s disease (PD) patients, has been found exported outside of cells and may mediate its toxicity via cell-to-cell transmission. Here, we reconstituted soluble, monomeric α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d7bba6ee4ec42cc6b80c86bd78f9f5
https://escholarship.org/uc/item/3gf867qn
https://escholarship.org/uc/item/3gf867qn
Autor:
Yoshiomi Kobayashi, Michiko Shigyo, Oleksandr Platoshyn, Silvia Marsala, Tomohisa Kato, Naoki Takamura, Kenji Yoshida, Akiyoshi Kishino, Mariana Bravo-Hernandez, Stefan Juhas, Jana Juhasova, Hana Studenovska, Vladimir Proks, Shawn P. Driscoll, Thomas D. Glenn, Samuel L. Pfaff, Joseph D. Ciacci, Martin Marsala
One of the challenges in clinical translation of cell-replacement therapies is the definition of optimal cell generation and storage/recovery protocols which would permit a rapid preparation of cell-treatment products for patient administration. Besi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b9ecf3ac1d23b186656c93e245919d
https://escholarship.org/uc/item/6sx7k61r
https://escholarship.org/uc/item/6sx7k61r
Autor:
Momoko Watanabe, Jessie E. Buth, Jillian R. Haney, Neda Vishlaghi, Felix Turcios, Lubayna S. Elahi, Wen Gu, Caroline A. Pearson, Arinnae Kurdian, Natella V. Baliaouri, Amanda J. Collier, Osvaldo A. Miranda, Natassia Dunn, Di Chen, Shan Sabri, Luis de la Torre-Ubieta, Amander T. Clark, Kathrin Plath, Heather R. Christofk, Harley I. Kornblum, Michael J. Gandal, Bennett G. Novitch
Publikováno v:
Stem cell reports, vol 17, iss 10
Telencephalic organoids generated from human pluripotent stem cells (hPSCs) are a promising system for studying the distinct features of the developing human brain and the underlying causes of many neurological disorders. While organoid technology is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07252158a4d10dae35565a44834d3fb7
https://escholarship.org/uc/item/66g278z4
https://escholarship.org/uc/item/66g278z4
Autor:
Neel S. Bhatt, Akshay Sharma, Andrew St. Martin, Muhammad Bilal Abid, Valerie I. Brown, Miguel Angel Diaz Perez, Haydar Frangoul, Shahinaz M. Gadalla, Megan M. Herr, Maxwell M. Krem, Hillard M. Lazarus, Michael J. Martens, Parinda A. Mehta, Taiga Nishihori, Tim Prestidge, Michael A. Pulsipher, Hemalatha G. Rangarajan, Kirsten M. Williams, Lena E. Winestone, Dwight E. Yin, Marcie L. Riches, Christopher E. Dandoy, Jeffery J. Auletta
Publikováno v:
Transplantation and cellular therapy, vol 28, iss 10
Adult hematopoietic stem cell transplantation (HSCT) recipients are at a high risk of adverse outcomes after COVID-19. Although children have had better outcomes after COVID-19 compared to adults, data on risk factors and outcomes of COVID-19 among p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7844523a39e4bd68f0d113b54cda10b
https://escholarship.org/uc/item/3sv0j8f1
https://escholarship.org/uc/item/3sv0j8f1
Autor:
Roni A. Hazim, Antonio E. Paniagua, Lisa Tang, Krista Yang, Kristen K.O. Kim, Linsey Stiles, Ajit S. Divakaruni, David S. Williams
Publikováno v:
The Journal of biological chemistry, vol 298, iss 9
In the mammalian retina, a metabolic ecosystem exists in which photoreceptors acquire glucose from the choriocapillaris with the help of the retinal pigment epithelium (RPE). While the photoreceptor cells are primarily glycolytic, exhibiting Warburg-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14160f490b2478def00f317f4365fbfc
https://escholarship.org/uc/item/46b2t142
https://escholarship.org/uc/item/46b2t142
Autor:
R. Michael Roberts, Toshihiko Ezashi, Jasmine Temple, Joseph R. Owen, Francesca Soncin, Mana M. Parast
Publikováno v:
Cellular and molecular life sciences : CMLS, vol 79, iss 8
Cell Mol Life Sci
Cell Mol Life Sci
The Bone Morphogenetic Protein (BMP) signaling pathway has established roles in early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has also been implicated in development of extraembryonic lineages, including trop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc12644b73a9e5a3c7d669396ca1bc5
https://escholarship.org/uc/item/7rm3x068
https://escholarship.org/uc/item/7rm3x068