Zobrazeno 81 - 90
of 333
pro vyhledávání: ''
Autor:
Sora Chee, Juan Carlos Izpisua Belmonte, Eugin Destici, Quan Zhu, Elie Farah, Rongxin Fang, Bing Ren, Sylvia M. Evans, Hui Huang, Sebastian Preissl, Jun Wu, Kaiyue Ma, Yanxiao Zhang, Rong Hu, Zhen Ye, Leqian Yu, Maria Luisa Amaral, Ah Young Lee, Yunjiang Qiu, Ting Li, Jonathan D. Grinstein, Neil C. Chi
Publikováno v:
Nature genetics, vol 51, iss 9
Nature genetics
Nature genetics
Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully elucidated. Here, by interrogating chromatin reorganization during human pluripotent stem cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad05b18d879b139bae248d20d0446ab
https://escholarship.org/uc/item/1q9817wd
https://escholarship.org/uc/item/1q9817wd
Autor:
Nikola Kolundzic, Preeti Khurana, Liani Devito, Jakob Jeriha, Jennifer Marx, Carl Hobbs, Xuan Fei Colin Cornelius Wong, John E.A. Common, Mirjana Liovic, Sandrine Dubrac, Robert Gruber, Matthias Schmuth, Theodora M. Mauro, Dusko Ilic
Publikováno v:
Stem Cell Research, Vol 39, Iss, Pp-(2019)
We have generated an induced pluripotent stem cell (iPSC) line KCLi003-A (iOP101) from epidermal keratinocytes of a female donor, heterozygous for the loss-of-function mutation p.R501X in the filaggrin gene (FLG), using non-integrating Sendai virus v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169abedc66d68607d3ffb92c4c6b2d13
https://escholarship.org/uc/item/3hc0w7b6
https://escholarship.org/uc/item/3hc0w7b6
Autor:
Alysson R. Muotri, Lucio Schiapparelli, John R. Yates, Daniel R. McClatchy, Cassiano Carromeu, Hollis T. Cline, Pinar Mesci, Pranav Sharma
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 32
Exosomes are thought to be released by all cells in the body and to be involved in intercellular communication. We tested whether neural exosomes can regulate the development of neural circuits. We show that exosome treatment increases proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a58277a33ae93e4239f228aa89e5884
https://escholarship.org/uc/item/5js883ct
https://escholarship.org/uc/item/5js883ct
Autor:
David T. Paik, Joseph C. Wu, Hao Zhang, Mengcheng Shen, Haodi Wu, Mingxia Gu, Chengyi Tu, Lei Tian
Publikováno v:
Circulation research, vol 125, iss 5
Circ Res
Circ Res
Rationale: Activated fibroblasts are the major cell type that secretes excessive extracellular matrix in response to injury, contributing to pathological fibrosis and leading to organ failure. Effective anti-fibrotic therapeutic solutions, however, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a1633e0c3cd7fd92ea94685da40f11
https://escholarship.org/uc/item/3m55x7pf
https://escholarship.org/uc/item/3m55x7pf
Autor:
Qing Nie, Maksim V. Plikus
Publikováno v:
Nature cell biology, vol 21, iss 8
Nat Cell Biol
Nat Cell Biol
Tissue renewal requires proliferative progenitors with long-lasting potential. Designated stem cells within specialized niches are considered to be the primary mechanism for this requirement. Recent studies show that dispersed equipotent progenitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b10e9e9eb3bfb8bf56afc6f2df007e
https://escholarship.org/uc/item/8nj7z99k
https://escholarship.org/uc/item/8nj7z99k
Autor:
Toshio Heike, Hirohiko Kohjitani, Koichi Matsuda, Katsutsugu Umeda, Takuya Hirata, Bruce R. Conklin, Kentaro Akagi, Daisuke Yoshinaga, Hirofumi Shibata, Junko Takita, Takeru Makiyama, Shiro Baba, Yimin Wuriyanghai, Yuta Yamamoto, Minoru Horie
Publikováno v:
Stem cell reports, vol 13, iss 2
Stem Cell Reports
Stem Cell Reports, Vol 13, Iss 2, Pp 394-404 (2019)
Stem Cell Reports
Stem Cell Reports, Vol 13, Iss 2, Pp 394-404 (2019)
Summary For long QT syndrome (LQTS), recent progress in genome-sequencing technologies enabled the identification of rare genomic variants with diagnostic, prognostic, and therapeutic implications. However, pathogenic stratification of the identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fc4ed93010f7146769d160c5007a0f
https://escholarship.org/uc/item/4rr8h4gf
https://escholarship.org/uc/item/4rr8h4gf
Autor:
Danica Chen, Candace Kerr
Publikováno v:
Trends in cell biology, vol 29, iss 7
Trends Cell Biol
Trends Cell Biol
Emerging evidence indicates that epigenetic regulators are critically required for the maintenance of tissue-specific stem cells and that the epigenetic marks are altered in stem cells during physiological aging. Intriguingly, aging-associated stem c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ea5eb6ea53b8b441c7f12752921677
https://escholarship.org/uc/item/83t10377
https://escholarship.org/uc/item/83t10377
Publikováno v:
Scientific reports, vol 9, iss 1
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
In this study, we have developed highly expandable neural stem cells (NSCs) from HESCs and iPSCs that artificially express the oligodendrocyte (OL) specific transcription factor gene Zfp488. This is enough to restrict them to an exclusive oligodendro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61ae32aa2745647c1ae619ba17108ad
https://escholarship.org/uc/item/4zc7b18c
https://escholarship.org/uc/item/4zc7b18c
Autor:
David T. Scadden, Isabel Beerman, Xuefeng Sun, Colin Crist, Annarita Scaramozza, Charles P. Lin, Swapna Kollu, Andrew S. Brack, Dongsu Park, Derrick J. Rossi
Publikováno v:
Cell stem cell, vol 24, iss 6
Stem cell heterogeneity is recognized as functionally relevant for tissue homeostasis and repair. The identity, context dependence, and regulation of skeletal muscle satellite cell (SC) subsets remains poorly understood. We identify a minor subset of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0379a85327ec9a58eb99afd26a050a78
https://escholarship.org/uc/item/7wg81139
https://escholarship.org/uc/item/7wg81139
Autor:
Jinxuan Zheng, Timothy G. Bromage, Xin Shi, Qimei Gong, Ling Ye, Hanying Bai, David W. Rowe, Wen Zhang, Hai Yao, Sainan Wang, Kenian Chen, Nick Tovar, Alexander Romanov, Songlin Wang, Ling He, Bin Cheng, Xinquan Jiang, Wei Gu, David J. Zegarelli, Yuting Niu, Zuolin Wang, Jeremy J. Mao, Changcheng Shi, Dennis P. Tarnow, Jia Qian Wu, Sahng G. Kim, Lusai Xiang, Jian Zhou, David M. Owens, G. W. Yang, Juan Zhong, Jiayi Cheng, Myron Finkel, Yue Zhou, Ming Xie, Chyuan Sheng Lin, Jin Wen, Jasmine Pei, Xuedong Zhou, Mo Chen, Milda Stanislauskas, Gregory Chotkowski, Bin Hu, Junyuan Li, Tzong-Jen Sheu, Paulo G. Coelho, Lukasz Witek, Junqi Ling
Publikováno v:
Nature materials, vol 18, iss 6
Cells are transplanted to regenerate an organs’ parenchyma, but how transplanted parenchymal cells induce stromal regeneration is elusive. Despite the common use of a decellularized matrix, little is known as to the pivotal signals that must be res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938b34e9250877dc3780786b1973170d
https://escholarship.org/uc/item/3kg8s59g
https://escholarship.org/uc/item/3kg8s59g