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Pompe disease is an autosomal recessive lysosomal storage disease caused by pathogenic variants in GAA, which encodes an enzyme integral to glycogen catabolism, acid α-glucosidase. Disease-relevant cell lines are necessary to evaluate the efficacy o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674f754760e8b128a21849e99b836d3a
https://escholarship.org/uc/item/4ds0566v
https://escholarship.org/uc/item/4ds0566v
Autor:
Chengsheng Wu, Taha Rakhshandehroo, Hiromi I. Wettersten, Alejandro Campos, Tami von Schalscha, Shashi Jain, Ziqi Yu, Jiali Tan, Evangeline Mose, Betzaira G. Childers, Andrew M. Lowy, Sara M. Weis, David A. Cheresh
Publikováno v:
Nature cell biology, vol 25, iss 2
Nat Cell Biol
Nat Cell Biol
Defining drivers of tumour initiation can provide opportunities to control cancer progression. Here we report that lysophosphatidic acid receptor 4 (LPAR4) becomes transiently upregulated on pancreatic cancer cells exposed to environmental stress or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7183f74989b8a5e50b8abbec1e8ef4a
https://escholarship.org/uc/item/3xs321vw
https://escholarship.org/uc/item/3xs321vw
Autor:
Yoshihiro Ishikawa, Yuki Taga, Thibault Coste, Sara F. Tufa, Douglas R. Keene, Kazunori Mizuno, Elisabeth Tournier-Lasserve, Douglas B. Gould
Publikováno v:
The Journal of biological chemistry, vol 298, iss 12
Collagens are the most abundant proteins in the body and among the most biosynthetically complex. A molecular ensemble of over 20 endoplasmic reticulum resident proteins participates in collagen biosynthesis and contributes to heterogeneous post-tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbeff3dfb1980b0d8730a3cad73f362
https://escholarship.org/uc/item/0gs5w663
https://escholarship.org/uc/item/0gs5w663
Publikováno v:
Nature chemical biology, vol 18, iss 11
Drugs that directly impede the function of driver oncogenes offer exceptional efficacy and a therapeutic window. The recently approved mutant selective small-molecule cysteine-reactive covalent inhibitor of the G12C mutant of K-Ras, sotorasib, provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f99ee2b36a87a1a5eded7000a7e677
https://escholarship.org/uc/item/6xh921w2
https://escholarship.org/uc/item/6xh921w2
Autor:
Daniel Q, Huang, Amit G, Singal, Yuko, Kono, Darren J H, Tan, Hashem B, El-Serag, Rohit, Loomba
Publikováno v:
Cell metabolism, vol 34, iss 7
Cell Metab
Cell Metab
Liver cancer epidemiology is changing due to increasing alcohol consumption, rising prevalence of obesity, and advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) treatment. However, the impact of these changes on global liver cancer burd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695b5f385014c5987a9f850e71874612
https://escholarship.org/uc/item/49h8k4rz
https://escholarship.org/uc/item/49h8k4rz
Autor:
Wei Yan, Minghui Cao, Xianhui Ruan, Li Jiang, Sylvia Lee, Adriana Lemanek, Majid Ghassemian, Donald P. Pizzo, Yuhao Wan, Yueqing Qiao, Andrew R. Chin, Erika Duggan, Dong Wang, John P. Nolan, Jeffrey D. Esko, Simon Schenk, Shizhen Emily Wang
Publikováno v:
Nature cell biology, vol 24, iss 5
A decline in skeletal muscle mass and low muscular strength are prognostic factors in advanced human cancers. Here we found that breast cancer suppressed O-linked N-acetylglucosamine (O-GlcNAc) protein modification in muscle through extracellular-ves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8241931457664538dc22b4bb47a626
https://escholarship.org/uc/item/0qp585kz
https://escholarship.org/uc/item/0qp585kz
Publikováno v:
Biochem Pharmacol
The Hedgehog (Hh) family of lipid-modified signaling proteins directs embryonic tissue patterning and postembryonic tissue homeostasis, and dysregulated Hh signaling drives familial and sporadic cancers. Hh ligands bind to and inhibit the tumor suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e41d47683cea1a2be693eb6730efed
https://escholarship.org/uc/item/1jh7c8jg
https://escholarship.org/uc/item/1jh7c8jg
Autor:
Jaymin J. Kathiriya, Chaoqun Wang, Minqi Zhou, Alexis Brumwell, Monica Cassandras, Claude Jourdan Le Saux, Max Cohen, Kostantinos-Dionysios Alysandratos, Bruce Wang, Paul Wolters, Michael Matthay, Darrell N. Kotton, Harold A. Chapman, Tien Peng
Publikováno v:
Nature cell biology, vol 24, iss 1
Loss of alveolar type 2 cells (AEC2s) and the ectopic appearance of basal cells in the alveoli characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we demonstrate that human alveolar type 2 cells (hAEC2s), unlike murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a23d5ce0833a4e930fbaf6763f481b
https://escholarship.org/uc/item/2qh206wf
https://escholarship.org/uc/item/2qh206wf
Publikováno v:
RNA (New York, N.Y.), vol 27, iss 12
RNA
RNA
DDX3 is a DEAD-box RNA helicase that regulates translation and is encoded by the X- and Y-linked paralogsDDX3XandDDX3Y. While DDX3X is ubiquitously expressed in human tissues and essential for viability, DDX3Y is male-specific and shows lower and mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dec65a28f7797b3069dc3f648130932
https://escholarship.org/uc/item/4zr6x7w0
https://escholarship.org/uc/item/4zr6x7w0
Autor:
Michael J. Emanuele, Nicholas G. Brown, Jeremy E. Purvis, Xianxi Wang, Seth M. Rubin, Peter Ngoi, Wayne Stallaert, Taylor P. Enrico, Elizaveta T Wick
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Cell cycle gene expression programs fuel proliferation and are universally dysregulated in cancer. The retinoblastoma (RB)-family of proteins, RB1, RBL1/p107, and RBL2/p130, coordinately represses cell cycle gene expression, inhibiting proliferation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720f33fb52706b3e083f65286fba3426
https://escholarship.org/uc/item/8599v3g3
https://escholarship.org/uc/item/8599v3g3