Zobrazeno 1 - 10
of 85
pro vyhledávání: ''
Autor:
Prajakta Ghatpande, Risa Kashima, Hanna S. Loving, Eric S. Underbakke, Pelin Ayaz, Christopher R. Agnew, Akiko Hata, Jennifer E. Kung, Natalia Jura, Yibing Shan, David E. Shaw
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Upon ligand binding, bone morphogenetic protein (BMP) receptors form active tetrameric complexes, comprised of two type I and two type II receptors, which then transmit signals to SMAD proteins. The link between receptor tetramerization and the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bb04004f967bab4eb43abfb24c4418
https://escholarship.org/uc/item/66k326b8
https://escholarship.org/uc/item/66k326b8
Autor:
Nimi M. Patel, Huan Wang, Reece M. Hoffmann, Jong Won Yang, Shujuan Gao, Karen Reue, Weijing Gu, Yong Mi Choi, Kaelin D. Fleming, John E. Burke, Michael V. Airola
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Phospholipid synthesis and fat storage as triglycerides are regulated by lipin phosphatidic acid phosphatases (PAPs), whose enzymatic PAP function requires association with cellular membranes. Using hydrogen deuterium exchange mass spectrometry, we f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b3614ae3e143f70257245699b7b27b
https://escholarship.org/uc/item/5ng3377s
https://escholarship.org/uc/item/5ng3377s
Publikováno v:
RNA biology, vol 18, iss 8
La-related proteins 7 (LARP7) are a class of RNA chaperones that bind the 3′ ends of RNA and are constitutively associated with their specific target RNAs. In metazoa, Larp7 binds to the long non-coding 7SK RNA as a core component of the 7SK RNP, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7029c76ad10023d442e8e40d0262dbaf
https://escholarship.org/uc/item/9rj7t5v4
https://escholarship.org/uc/item/9rj7t5v4
Autor:
Michael Downes, Maziar Hafezi-Bakhtiari, Joseph M. Valentine, Yuan Zhang, David J. Mangelsdorf, Xin Zhou, Christopher Liddle, Steven A. Kliewer, Jin Zhang, Ronald M. Evans, Yang Dai, Hadeel Ashayer, Lana Mamoun, Alan R. Saltiel, Mohammad Abu-Odeh, Shannon M. Reilly, Nima Ebadat, Ruth T. Yu, Omer Keinan
Publikováno v:
Cell reports, vol 35, iss 13
Cell Reports, Vol 35, Iss 13, Pp 109331-(2021)
Cell reports
Cell Reports, Vol 35, Iss 13, Pp 109331-(2021)
Cell reports
SUMMARY The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires autocrine FGF21 signaling. Adipose-specific deletion of the FGF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0b260b1979af2e3c71fec90fe8e1a2
https://escholarship.org/uc/item/2q37b2cj
https://escholarship.org/uc/item/2q37b2cj
Autor:
Mary K. Lewinski, John C. Guatelli, Aaron L. Oom, Charlotte A. Stoneham, Daniela V. Castro, Haley Siddiqi, Ben A. Croker, Stanley J. Opella, Sang Ho Park, Alex E. Clark, Aaron F. Carlin, Anna A. De Angelis
Publikováno v:
PLoS pathogens, vol 17, iss 5
PLoS Pathogens, Vol 17, Iss 5, p e1009519 (2021)
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 5, p e1009519 (2021)
PLoS Pathogens
SARS-CoV-2 is the novel coronavirus that is the causative agent of COVID-19, a sometimes-lethal respiratory infection responsible for a world-wide pandemic. The envelope (E) protein, one of four structural proteins encoded in the viral genome, is a 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c20489ebca7cc3c7699c09635ede84
https://escholarship.org/uc/item/8jk636qf
https://escholarship.org/uc/item/8jk636qf
Autor:
Yoko K. Takada, Yoshikazu Takada, Brunie H. Felding, Michiko Shimoda, Emanual Michael Maverakis, R. Holland Cheng
Publikováno v:
The Journal of Biological Chemistry
CD40L is a member of the TNF superfamily that participates in immune cell activation. It binds to and signals through several integrins, including αvβ3 and α5β1, which bind to the trimeric interface of CD40L. We previously showed that several int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6191d675f4052263c7a3fcb13012090e
https://escholarship.org/uc/item/1rd6p7gm
https://escholarship.org/uc/item/1rd6p7gm
Autor:
Navin Rajapakse, Pradipta Ghosh, Soni Khandelwal, Majid Ghassemian, Luke McCaffrey, Tony Ngo, Suchismita Roy, Amer Ali Abd El-Hafeez, Jason Ear, Julie Choi, Irina Kufareva, Debashis Sahoo
Publikováno v:
The Journal of Biological Chemistry
PDZ domains are one of the most abundant protein domains in eukaryotes and are frequently found on junction-localized scaffold proteins. Various signaling molecules bind to PDZ proteins via PDZ-binding motifs (PBM) and fine-tune cellular signaling. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0282ea22e2fca657bcf7c2b2975b6dde
https://escholarship.org/uc/item/03d8f26n
https://escholarship.org/uc/item/03d8f26n
Autor:
Hristina R. Zhekova, Mirna Damergi, Gülru Kayık, Ira Kurtz, Alexander Pushkin, Natalia Abuladze, Debra Kurtz, Rustam Azimov, Liyo Kao, Sergei Y. Noskov
Publikováno v:
The Journal of Biological Chemistry
Solute carrier family 4 (SLC4) transporters mediate the transmembrane transport of HCO3-, CO32-, and Cl- necessary for pH regulation, transepithelial H+/base transport, and ion homeostasis. Substrate transport with varying stoichiometry and specifici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8603cdbd59a9f9df637619b7127ac7f5
https://escholarship.org/uc/item/6rn7m91k
https://escholarship.org/uc/item/6rn7m91k
Autor:
Alma L. Burlingame, Warren Emmett, Andreas Blees, Fabian Brunk, Silvia Surinova, Anne E. Roehrig, Marta Munoz-Alegre, Alexander Hergovich, Kristina Klupsch, Maha Tijani, Anett Pfeiffer, Juan A. Oses-Prieto, Stephen Henderson, Pablo Rodriguez-Viciana, Nicole Hartig, Selim Chaib, Barbara H. Jennings, Lucy C. Young
Publikováno v:
PloS one, vol 16, iss 8
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0254697 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0254697 (2021)
The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and nucleus and is a key mediator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230e0538a32a3dbbdd2c44b48de833dd
https://escholarship.org/uc/item/57d9s6th
https://escholarship.org/uc/item/57d9s6th
Autor:
Parisha P. Shah, Arun Padmanabhan, Franco Felix, Ricardo Linares-Saldana, Rajan Jain, Andrew J. Connolly, Qiming Duan, Michael Alexanian, Qiaohong Wang, Wonho Kim, Saptarsi M. Haldar, Austin Hsu, Gaia Andreoletti, Yu Huang, Sarah A. B. Winchester, Juan A. Perez-Bermejo, Bárbara González-Terán, Li Li, Deepak Srivastava
Publikováno v:
Circulation, vol 142, iss 24
Background: Gene regulatory networks control tissue homeostasis and disease progression in a cell type–specific manner. Ubiquitously expressed chromatin regulators modulate these networks, yet the mechanisms governing how tissue specificity of thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2f901da1e37ad46432723db6cc69f5
https://escholarship.org/uc/item/9592f6t2
https://escholarship.org/uc/item/9592f6t2