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of 99
pro vyhledávání: ''
Autor:
Momoko Watanabe, Jessie E. Buth, Jillian R. Haney, Neda Vishlaghi, Felix Turcios, Lubayna S. Elahi, Wen Gu, Caroline A. Pearson, Arinnae Kurdian, Natella V. Baliaouri, Amanda J. Collier, Osvaldo A. Miranda, Natassia Dunn, Di Chen, Shan Sabri, Luis de la Torre-Ubieta, Amander T. Clark, Kathrin Plath, Heather R. Christofk, Harley I. Kornblum, Michael J. Gandal, Bennett G. Novitch
Publikováno v:
Stem cell reports, vol 17, iss 10
Telencephalic organoids generated from human pluripotent stem cells (hPSCs) are a promising system for studying the distinct features of the developing human brain and the underlying causes of many neurological disorders. While organoid technology is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07252158a4d10dae35565a44834d3fb7
https://escholarship.org/uc/item/66g278z4
https://escholarship.org/uc/item/66g278z4
Autor:
Jian Wu, Sabine Pautz, Bjørn Steen Skålhegg, Friedrich W. Herberg, Evan K. Kobori, Kristoffer Søberg, Susan S. Taylor
Publikováno v:
Molecular pharmacology, vol 101, iss 4
Mol Pharmacol
Mol Pharmacol
Protein kinase A (PKA) is a holoenzyme consisting of a regulatory (R)-subunit dimer and two catalytic (C)-subunits. There are two major families of C-subunits, Cα and Cβ, and four functionally nonredundant R-subunits (RIα, RIβ, RIIα, RIIβ). In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d9baae224a1d1d8853ecc1b65e3af2
https://escholarship.org/uc/item/1mx7d9d7
https://escholarship.org/uc/item/1mx7d9d7
Autor:
Yinan Zheng, Mohamad Habes, Mitzi Gonzales, Raymond Pomponio, Ilya Nasrallah, Sadiya Khan, Douglas E. Vaughan, Christos Davatzikos, Sudha Seshadri, Lenore Launer, Farzaneh Sorond, Sanaz Sedaghat, Derek Wainwright, Andrea Baccarelli, Stephen Sidney, Nick Bryan, Philip Greenland, Donald Lloyd-Jones, Kristine Yaffe, Lifang Hou
Publikováno v:
Aging, vol 14, iss 4
The proportion of aging populations affected by dementia is increasing. There is an urgent need to identify biological aging markers in mid-life before symptoms of age-related dementia present for early intervention to delay the cognitive decline and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56222133606c742efc42592df68ba0b9
https://escholarship.org/uc/item/2mf98672
https://escholarship.org/uc/item/2mf98672
Autor:
Samhita Jain, Maximilian Haeussler, Tao Li, Keith B. Hengen, Tomasz J. Nowakowski, David Shin, Richard R. Ransohoff, Kelsey M. Hennick, Shalin B. Mehta, Christopher S. McGinnis, Matthew L. Speir, Zev J. Gartner, Matthew G. Keefe, Chang N. Kim, Sarah S. Soliman, Bryant B. Chhun, Dario Tejera, Xianhua Piao, Galina Popova
Publikováno v:
Cell stem cell, vol 28, iss 12
Microglia are resident macrophages in the brain that emerge in early development and respond to the local environment by altering their molecular and phenotypic states. Fundamental questions about microglia diversity and function during development r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07501263c562907d27e7385a92f3f463
https://escholarship.org/uc/item/1xh229wx
https://escholarship.org/uc/item/1xh229wx
Autor:
Fengchun Zhang, Carlo Selmi, William M. Ridgway, M. Eric Gershwin, Zhilei Chen, Patrick S.C. Leung, Weici Zhang
Publikováno v:
Autoimmunity reviews, vol 20, iss 11
Autoimmun Rev
Autoimmun Rev
The myristoylated alanine-rich C-kinase substrate (MARCKS) and the MARCKS-related protein (MARCKSL1) are ubiquitous, highly conserved membrane-associated proteins involved in the structural modulation of the actin cytoskeleton, chemotaxis, motility,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e814541a33d417c11aff5866ad7b18b
https://escholarship.org/uc/item/0tq1f7hk
https://escholarship.org/uc/item/0tq1f7hk
Autor:
Jianqin Niu, Feng Mei, Stephen P.J. Fancy, Jonah R. Chan, Yuxin Wang, Xiaorui Wang, Lan Xiao, Guangdan Yu, Wenlong Xia, Kimberly K. Hoi
Publikováno v:
Neuron, vol 109, iss 19
Neuron
Neuron
Oligodendrocyte (OL) maturation arrest in human white matter injury contributes significantly to the failure of endogenous remyelination in multiple sclerosis (MS) and newborn brain injuries such as hypoxic ischemic encephalopathy (HIE) that cause ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcda9c045c5e743d6b62f22d0884c57e
https://escholarship.org/uc/item/9vb4k2nx
https://escholarship.org/uc/item/9vb4k2nx
Autor:
Marlesa Godoy, Xia Yang, Jiwen Li, William G Pembroke, Lin Pan, Michael C. Condro, Harley I. Kornblum, Jessica E. Rexach, Steven A. Goldman, Daniel H. Geschwind, Linsey Stiles, Yen-Wei Chen, Angela Y. Chen, Ye Zhang, Mineli Harteni, Ina B. Wanner, Alvaro G. Alvarado
Publikováno v:
Nature communications, vol 12, iss 1
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse models and the similarities and differences between human and mouse astrocytes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fdf29ea59d3d4b1e05472ac4de6a42
https://escholarship.org/uc/item/2290r3jj
https://escholarship.org/uc/item/2290r3jj
Autor:
Anamika Agrawal, Elena F. Koslover
Publikováno v:
PLoS computational biology, vol 17, iss 6
PLoS Computational Biology, Vol 17, Iss 6, p e1009073 (2021)
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 6, p e1009073 (2021)
PLoS Computational Biology
Neurons rely on localized mitochondria to fulfill spatially heterogeneous metabolic demands. Mitochondrial aging occurs on timescales shorter than the neuronal lifespan, necessitating transport of fresh material from the soma. Maintaining an optimal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2a2dedf58095c2601291028c58bfca
https://escholarship.org/uc/item/5td945np
https://escholarship.org/uc/item/5td945np
Autor:
Jiahao Liang, Jacob L. Capener, Kouki Kawakami, David Grunwald, Asuka Inoue, Jiewei Xu, Ruth Hüttenhain, Dana Klatt Shaw, John T. Happ, Ishan Deshpande, Isaac B. Nelson, Sara L. Stubben, Danielle S. Hedeen, Benjamin R. Myers, Aashish Manglik, Ju Fen Zhu, Nevan J. Krogan, Corvin D. Arveseth, Madison F. Walker
Publikováno v:
PLoS biology, vol 19, iss 4
PLoS Biology
PLoS Biology, Vol 19, Iss 4, p e3001191 (2021)
PLoS Biology
PLoS Biology, Vol 19, Iss 4, p e3001191 (2021)
The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein–coupled receptor (GPCR) Smoothened (SMO) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d2a619f7ac028a3d571337cec82c2f
https://escholarship.org/uc/item/0w43z8d9
https://escholarship.org/uc/item/0w43z8d9
Autor:
Steve Horvath, Simon T. Schafer, Dylan A. Reid, Ake T. Lu, Fred H. Gage, Christopher K. Glass, Patrick J. Reed, Grace Chou, Claire A. McClain, Jeffrey R. Jones, Jesse R. Dixon, Sahaana Chandran, Addison J. Lana, Anthony S. Ricciardulli, Enoch C. Tsui, Ioana I. Nitulescu, Tzu-Wen Wang, Jean H. Ooi, Shong Lau, Johannes C. M. Schlachetzki, Nasun Hah, Sara B. Linker
Publikováno v:
Science (New York, N.Y.), vol 372, iss 6537
Science
Science
DNA repair within neurons Humans have only a limited capacity to generate new neurons. These cells thus need to repair errors in the genome. To better understand this process, Reid et al. developed Repair-seq, a method to locate DNA repair within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d60dd82faff91dff991ec21a36ff828
https://escholarship.org/uc/item/5px9q677
https://escholarship.org/uc/item/5px9q677