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Autor:
Jean M. Kanellopoulos, David M. Ojcius
Publikováno v:
Biomedical journal, vol 45, iss 2
This special edition summarizes major advances in our understanding of signaling by T lymphocytes. T cell interactions with antigen-presenting cells (APCs) and other immune cells are characterized by changes in T cell adhesion and major rearrangement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b495b34d4c8945a280c51d4437da2a9c
https://escholarship.org/uc/item/71c0f9nr
https://escholarship.org/uc/item/71c0f9nr
Autor:
Marek Kudla, Jamie H. D. Cate, Ryan Apathy, Franziska Blaeschke, Alexander Marson, Nicholas T. Ingolia, Grant H. Chin, Dasmanthie DeSilva, Lucas Ferguson, Benjamin E. Smith, Theodore L. Roth
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Activation of T cells requires a rapid surge in cellular protein synthesis. However, the role of translation initiation in the early induction of specific genes remains unclear. Here we show human translation initiation factor eIF3 interacts with sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3e650dea40410ca334372dae668a23
https://escholarship.org/uc/item/19j6w3pc
https://escholarship.org/uc/item/19j6w3pc
Publikováno v:
Nature reviews. Immunology, vol 21, iss 11
Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and malignant cells and can provide long-term protective immunity. In the response to infection, CD8+ T cell metabolism is coupled to transcriptional, translational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de632eac1b1397241c357281c4512aa
https://escholarship.org/uc/item/1n49006c
https://escholarship.org/uc/item/1n49006c
Autor:
Richard L. Gallo, Marc C. Liggins, Tatsuya Dokoshi, George L. Sen, Teruaki Nakatsuji, Yu Sawada, Nikhil Nitin Kulkarni
Publikováno v:
Science immunology, vol 6, iss 59
Sci Immunol
Sci Immunol
The skin typically tolerates exposure to various microbes and chemicals in the environment. Here, we investigated how the epidermis maintains this innate immune tolerance to stimuli that are recognized by Toll-like receptors (TLRs). Loss of tolerance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d149e8175df57a15b8d0016b8ea81ccc
https://escholarship.org/uc/item/5db3p8h5
https://escholarship.org/uc/item/5db3p8h5
Autor:
Jonathan M. Woo, Sasha Targ, Kathrin Schumann, Matthew H. Spitzer, Michelle L.T. Nguyen, Alexander Marson, Chun Jimmie Ye, Theodore L. Roth, Nikolaos Skartsis, Michael Lauber, Ruby Yu, Qizhi Tang, David N. Nguyen, Jeffrey A. Bluestone, Saskia Kolb, Eric Shifrut, Siddharth S. Raju, Jessica T. Cortez, Rachel E. Gate, Vinh Son Nguyen, Dimitre R. Simeonov
Publikováno v:
Nature immunology, vol 21, iss 11
Nature immunology
Nature immunology
Human regulatory T (Treg) cells are essential for immune homeostasis. The transcription factor FOXP3 maintains Treg cell identity, yet the complete set of key transcription factors that control Treg cell gene expression remains unknown. Here, we used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7505bee01708a1d10ef7deae33334923
https://escholarship.org/uc/item/06z4n1xt
https://escholarship.org/uc/item/06z4n1xt
Autor:
Audrey Nosbaum, Joshua M. Moreau, Lokesh A. Kalekar, Anna Haemel, Michael Rosenblum, Priscila Munoz Sandoval, Anubhav N. Mathur, Jarish N. Cohen, Francesco Boin, Margaret M. Lowe, Nicolas Prevel, Paul J. Wolters
Publikováno v:
Science immunology, vol 4, iss 39
At the center of fibrosing diseases is the aberrant activation of tissue fibroblasts. The cellular and molecular mechanisms of how the immune system augments fibroblast activation have been described; however, little is known about how the immune sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9513653cf083553101ff16a9b1dea9
https://escholarship.org/uc/item/4pk1q351
https://escholarship.org/uc/item/4pk1q351
Autor:
Jay V. Solnick, Connie Fung, Tadashi Fukami, Jessica A. Klein, Luis F. Camarillo-Guerrero, Shumin Tan, Trevor D. Lawley, Mifuyu Nakajima, Emma C. Skoog, Manuel R. Amieva
Publikováno v:
PLoS biology, vol 17, iss 5
PLoS Biology
PLoS Biology, Vol 17, Iss 5, p e3000231 (2019)
PLoS Biology
PLoS Biology, Vol 17, Iss 5, p e3000231 (2019)
Lifelong infection of the gastric mucosa by Helicobacter pylori can lead to peptic ulcers and gastric cancer. However, how the bacteria maintain chronic colonization in the face of constant mucus and epithelial cell turnover in the stomach is unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74570ef66945d7951990c341ea192cc
https://escholarship.org/uc/item/1p05c4cs
https://escholarship.org/uc/item/1p05c4cs
Autor:
Alan L. Epstein, Bellur S. Prabhakar, Divya Raghunathan, Vandhana K Ragothaman, Shikha Saini, Prabhakaran Kumar, Alejandra Marinelarena, Ajay V. Maker, Jilao Fan, Palash Bhattacharya
Publikováno v:
Cellular & molecular immunology, vol 16, iss 2
Regulatory T cells (Tregs) play a pivotal role in immune-tolerance, and loss of Treg function can lead to the development of autoimmunity. Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery, where they su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58bb67c5bb2518a2c4f3b004c30bf9c
https://escholarship.org/uc/item/8c83c648
https://escholarship.org/uc/item/8c83c648
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
T cell activation is mediated by signaling pathways originating from the T cell receptor (TCR). Propagation of signals downstream of the TCR involves a cascade of numerous kinases, some of which have yet to be identified. Through a screening strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46bcff5f305161ef64e61bef618d838
https://escholarship.org/uc/item/56f063g6
https://escholarship.org/uc/item/56f063g6
Autor:
Dayong Gao, April L. Ferre, Barbara L. Shacklett, Peter L. Anderson, Gretchen M. Lentz, Michael F. Fialkow, Anna C Kirby, Chris A. R. Baker, Charlene S. Dezzutti, Claire N. Levy, Elizabeth Sinclair, Florian Hladik, Fernanda Calienes, Rena D. Astronomo, Sean M. Hughes, Cory Shetler, M. Juliana McElrath, Lisa C. Rohan, Zhiquan Shu, Sarah E Yandura
Publikováno v:
Hughes, SM; Ferre, AL; Yandura, SE; Shetler, C; Baker, CAR; Calienes, F; et al.(2018). Cryopreservation of human mucosal tissues. PLoS ONE, 13(7). doi: 10.1371/journal.pone.0200653. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/5hb228b7
PloS one, vol 13, iss 7
PLoS ONE, Vol 13, Iss 7, p e0200653 (2018)
PLoS ONE
PloS one, vol 13, iss 7
PLoS ONE, Vol 13, Iss 7, p e0200653 (2018)
PLoS ONE
© 2018 Hughes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21a93feae942f3d913f556df683b615
http://www.escholarship.org/uc/item/5hb228b7
http://www.escholarship.org/uc/item/5hb228b7