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Autor:
Anirban Chakraborty, Nisha Tapryal, Azharul Islam, Altaf H. Sarker, Kodavati Manohar, Joy Mitra, Muralidhar L. Hegde, Tapas Hazra
Publikováno v:
The Journal of biological chemistry, vol 299, iss 3
A growing body of evidence indicates that RNA plays a critical role in orchestrating DNA double-strand break repair (DSBR). Recently, we showed that homologous nascent RNA can be used as a template for error-free repair of double-strand breaks (DSBs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5012f3301fa2986e889e8a678e2542b1
https://escholarship.org/uc/item/7608k70j
https://escholarship.org/uc/item/7608k70j
Publikováno v:
The Journal of biological chemistry, vol 298, iss 9
In higher eukaryotes, mitochondria play multiple roles in energy production, signaling, and biosynthesis. Mitochondria possess multiple copies of mitochondrial DNA (mtDNA), which encodes 37 genes that are essential for mitochondrial and cellular func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29423ff87047b442e18909429d3540c1
https://escholarship.org/uc/item/44f7j4vb
https://escholarship.org/uc/item/44f7j4vb
Autor:
Pranidhi Sood, Athena Lin, Connie Yan, Rebecca McGillivary, Ulises Diaz, Tatyana Makushok, Ambika V Nadkarni, Sindy KY Tang, Wallace F Marshall
The giant ciliate Stentor coeruleus is a classical model system for studying regeneration and morphogenesis in a single cell. The anterior of the cell is marked by an array of cilia, known as the oral apparatus, which can be induced to shed and regen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f4307aea5242bc120efabf9de1d420
https://escholarship.org/uc/item/6wq2h5nb
https://escholarship.org/uc/item/6wq2h5nb
Autor:
Francesca Soncin, Robert Morey, Tony Bui, Daniela F. Requena, Virginia Chu Cheung, Sampada Kallol, Ryan Kittle, Madeline G. Jackson, Omar Farah, Jennifer Chousal, Morgan Meads, Donald Pizzo, Mariko Horii, Kathleen M. Fisch, Mana M. Parast
Publikováno v:
Stem cell reports, vol 17, iss 6
Trophoblast stem cells (TSCs) have recently been derived from human embryos and early-first-trimester placenta; however, aside from ethical challenges, the unknown disease potential of these cells limits their scientific utility. We have previously e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eee5d799f74229d139f6e2af17d5133
https://escholarship.org/uc/item/3112255s
https://escholarship.org/uc/item/3112255s
Publikováno v:
J Mol Cell Cardiol
Since the initial isolation of human embryonic stem cells and subsequent discovery of reprogramming methods for somatic cells, thousands of protocols have been developed to create each of the hundreds of cell types found in-vivo with significant focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81c15000810c1ee24eded95cdbe7db1
https://escholarship.org/uc/item/6sp868hn
https://escholarship.org/uc/item/6sp868hn
Publikováno v:
RNA (New York, N.Y.), vol 27, iss 12
RNA
RNA
DDX3 is a DEAD-box RNA helicase that regulates translation and is encoded by the X- and Y-linked paralogsDDX3XandDDX3Y. While DDX3X is ubiquitously expressed in human tissues and essential for viability, DDX3Y is male-specific and shows lower and mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dec65a28f7797b3069dc3f648130932
https://escholarship.org/uc/item/4zr6x7w0
https://escholarship.org/uc/item/4zr6x7w0
Autor:
Michael J. Emanuele, Nicholas G. Brown, Jeremy E. Purvis, Xianxi Wang, Seth M. Rubin, Peter Ngoi, Wayne Stallaert, Taylor P. Enrico, Elizaveta T Wick
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Cell cycle gene expression programs fuel proliferation and are universally dysregulated in cancer. The retinoblastoma (RB)-family of proteins, RB1, RBL1/p107, and RBL2/p130, coordinately represses cell cycle gene expression, inhibiting proliferation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720f33fb52706b3e083f65286fba3426
https://escholarship.org/uc/item/8599v3g3
https://escholarship.org/uc/item/8599v3g3
Autor:
Rajarshi Ghosh, B. Gayani K. Perera, Feroz R. Papa, Venkata Narayana Vidadala, Vincent C. Auyeung, Zachary E. Potter, Alina Olivier, Julie Zikherman, Jae-Hong Kim, Dustin J. Maly, James L. Mueller, Bradley J. Backes, Hannah C. Feldman
Publikováno v:
Nature chemical biology, vol 17, iss 11
The unfolded protein response (UPR) homeostatically matches endoplasmic reticulum (ER) protein-folding capacity to cellular secretory needs. However, under high or chronic ER stress, the UPR triggers apoptosis. This cell fate dichotomy is promoted by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0723837b01d50cfdb07ac11767477d32
https://escholarship.org/uc/item/68f3g7m2
https://escholarship.org/uc/item/68f3g7m2
Autor:
Sohit Miglani, Hao G. Nguyen, Juan A. Oses-Prieto, Yichen Xu, Emily Devericks, Davide Ruggero, Xiuyan Yu, Peiwei Huangyang, Hani Goodarzi, Alma L. Burlingame, Ying Wang, Lingru Xue
Publikováno v:
Cell, vol 184, iss 20
Estrogen receptor α (ERα) is a hormone receptor and key driver for over 70% of breast cancers that has been studied for decades as a transcription factor. Unexpectedly, we discover that ERα is a potent non-canonical RNA-binding protein. We show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a20e0060b969f4042d52f824388853
https://escholarship.org/uc/item/03g9d79q
https://escholarship.org/uc/item/03g9d79q
Protein phosphorylation and dephosphorylation is central to signal transduction in nearly every aspect of cellular function, including cardiovascular regulation and diseases. While protein kinases are often regarded as the molecular drivers in cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8149e0a7628adbe2999c0b8f1a693455
https://escholarship.org/uc/item/7wx0882d
https://escholarship.org/uc/item/7wx0882d