Zobrazeno 1 - 10
of 40
pro vyhledávání: ''
Autor:
Rajarshi Ghosh, B. Gayani K. Perera, Feroz R. Papa, Venkata Narayana Vidadala, Vincent C. Auyeung, Zachary E. Potter, Alina Olivier, Julie Zikherman, Jae-Hong Kim, Dustin J. Maly, James L. Mueller, Bradley J. Backes, Hannah C. Feldman
Publikováno v:
Nature chemical biology, vol 17, iss 11
The unfolded protein response (UPR) homeostatically matches endoplasmic reticulum (ER) protein-folding capacity to cellular secretory needs. However, under high or chronic ER stress, the UPR triggers apoptosis. This cell fate dichotomy is promoted by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0723837b01d50cfdb07ac11767477d32
https://escholarship.org/uc/item/68f3g7m2
https://escholarship.org/uc/item/68f3g7m2
Autor:
Nimi M. Patel, Huan Wang, Reece M. Hoffmann, Jong Won Yang, Shujuan Gao, Karen Reue, Weijing Gu, Yong Mi Choi, Kaelin D. Fleming, John E. Burke, Michael V. Airola
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Phospholipid synthesis and fat storage as triglycerides are regulated by lipin phosphatidic acid phosphatases (PAPs), whose enzymatic PAP function requires association with cellular membranes. Using hydrogen deuterium exchange mass spectrometry, we f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b3614ae3e143f70257245699b7b27b
https://escholarship.org/uc/item/5ng3377s
https://escholarship.org/uc/item/5ng3377s
Publikováno v:
RNA biology, vol 18, iss 8
La-related proteins 7 (LARP7) are a class of RNA chaperones that bind the 3′ ends of RNA and are constitutively associated with their specific target RNAs. In metazoa, Larp7 binds to the long non-coding 7SK RNA as a core component of the 7SK RNP, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7029c76ad10023d442e8e40d0262dbaf
https://escholarship.org/uc/item/9rj7t5v4
https://escholarship.org/uc/item/9rj7t5v4
Autor:
Nicholas A. Larsen, Xiang Liu, Patricia Gee, Andrew Cook, Constantin Cretu, Melissa S. Jurica, Vladimir Pena, Anant A. Agrawal, Tuong-Vi Nguyen, Arun K. Ghosh
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Intron selection during the formation of prespliceosomes is a critical event in pre-mRNA splicing. Chemical modulation of intron selection has emerged as a route for cancer therapy. Splicing modulators alter the splicing patterns in cells by binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f425751521a803c9bd864ce99295a846
https://escholarship.org/uc/item/3sr415kn
https://escholarship.org/uc/item/3sr415kn
Autor:
George E. Ghanim, Kathleen Collins, Rhiju Das, Adam J. Fountain, Ramya Rangan, Thi Hoang Duong Nguyen, Anne-Marie M. van Roon
Publikováno v:
Nature, vol 593, iss 7859
Nature
Nature
Telomerase adds telomeric repeats at chromosome ends to compensate for the telomere loss that is caused by incomplete genome end replication1. In humans, telomerase is upregulated during embryogenesis and in cancers, and mutations that compromise the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87713b8704f264df1202f35546bba4ab
https://escholarship.org/uc/item/5v97b0vv
https://escholarship.org/uc/item/5v97b0vv
Autor:
Chi Lin Tsai, Ivaylo Ivanov, Orlando D. Schärer, Amer Bralic, Chunli Yan, Samir M. Hamdan, Susan E. Tsutakawa, John A. Tainer, Walter J. Chazin
Publikováno v:
DNA Repair (Amst)
Critical for transcription initiation and bulky lesion DNA repair, TFIIH provides an exemplary system to connect molecular mechanisms to biological outcomes due to its strong genetic links to different specific human diseases. Recent advances in stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82665d1c5f34ceff74417fbfbdf22073
https://escholarship.org/uc/item/6w3292vk
https://escholarship.org/uc/item/6w3292vk
Autor:
Oliver Fiehn, Xin Lin, Baohua Cao, Joseph H. Graziano, Jaume Taura, William J. Rice, Kimberly M. Ray, Jonathan Liu, Yong Geng, Wayne A. Hendrickson, Zhiheng Yu, Shaoxia Chen, Matthias Quick, Hongtao Yu, Aurel Frangaj, Vesna Slavkovich, Ziao Fu, Joachim Frank, Rick Huang, Zheng Liu, Rajesh Kumar Soni, Justin P. Williams, Hao Zuo, Edward T. Eng, Qing R. Fan, Paul A. Slesinger, Robert A. Grassucci, Yongjun Kou, Oliver B. Clarke, Brian Kloss, Jinseo Park, Tong Shen, Lidia Mosyak, Jonathan A. Javitch
Publikováno v:
Nature, vol 584, iss 7820
Nature
Nature
The human GABAB receptor-a member of the class C family of G-protein-coupled receptors (GPCRs)-mediates inhibitory neurotransmission and has been implicated in epilepsy, pain and addiction1. A unique GPCR that is known to require heterodimerization f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dadef2025ff06af84fa9bb429a1c481
https://escholarship.org/uc/item/0n8972fx
https://escholarship.org/uc/item/0n8972fx
Autor:
Tilini U. Wijeratne, Susan Strome, Braden J. Larson, Paul J. Vorster, Seth M. Rubin, Laura Andrejka, Paul D. Goetsch, Joseph S. Lipsick, Sarvind Tripathi, Keelan Z. Guiley
Publikováno v:
Biology open, vol 9, iss 5
Biology Open, Vol 9, Iss 5 (2020)
Biology Open
article-version (VoR) Version of Record
Biology Open, Vol 9, Iss 5 (2020)
Biology Open
article-version (VoR) Version of Record
The five-protein MuvB core complex is highly conserved in animals. This nuclear complex interacts with RB-family tumor suppressor proteins and E2F-DP transcription factors to form DREAM complexes that repress genes that regulate cell cycle progressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84cdfaf99c9d32c12de2f2cc0be9778
https://escholarship.org/uc/item/66v885zv
https://escholarship.org/uc/item/66v885zv
Publikováno v:
International journal of molecular sciences, vol 21, iss 7
International Journal of Molecular Sciences, Vol 21, Iss 2474, p 2474 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 7
International Journal of Molecular Sciences, Vol 21, Iss 2474, p 2474 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 7
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the biological and toxicological effects of an AhR lacking the entire PASB structurally diverse chemicals, including halogenated aromatic hydrocarbons. Ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dd6adcbe48798fe45c653e678236d4
https://escholarship.org/uc/item/7bp780sq
https://escholarship.org/uc/item/7bp780sq
Autor:
Meirong Bai, Dean Sheppard, Thomas B. Kornberg, Shuo Luo, Zhe Zhang, Yuehua Wei, Xin Wang, Tatsuya Tsukui, Andrew T. Chen, Guilherme Oliveira Barbosa, Bingying Wang, Hao Li, Dengke K. Ma
Publikováno v:
Science advances, vol 6, iss 7
Science Advances
Science Advances
Collagen production and secretion in cells of diverse organisms require a novel family of transmembrane proteins.
Collagen is the most abundant protein in animals. Its dysregulation contributes to aging and many human disorders, including pathol
Collagen is the most abundant protein in animals. Its dysregulation contributes to aging and many human disorders, including pathol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f94f80abdf5fe462149cab0029d8d3
https://escholarship.org/uc/item/5mw1n25c
https://escholarship.org/uc/item/5mw1n25c