Zobrazeno 1 - 10
of 109
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Publikováno v:
J Mol Cell Cardiol
Since the initial isolation of human embryonic stem cells and subsequent discovery of reprogramming methods for somatic cells, thousands of protocols have been developed to create each of the hundreds of cell types found in-vivo with significant focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81c15000810c1ee24eded95cdbe7db1
https://escholarship.org/uc/item/6sp868hn
https://escholarship.org/uc/item/6sp868hn
Autor:
Marlesa Godoy, Xia Yang, Jiwen Li, William G Pembroke, Lin Pan, Michael C. Condro, Harley I. Kornblum, Jessica E. Rexach, Steven A. Goldman, Daniel H. Geschwind, Linsey Stiles, Yen-Wei Chen, Angela Y. Chen, Ye Zhang, Mineli Harteni, Ina B. Wanner, Alvaro G. Alvarado
Publikováno v:
Nature communications, vol 12, iss 1
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse models and the similarities and differences between human and mouse astrocytes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fdf29ea59d3d4b1e05472ac4de6a42
https://escholarship.org/uc/item/2290r3jj
https://escholarship.org/uc/item/2290r3jj
Autor:
Elmira Forouzmand, Mason W. Schechter, Michelle Ficht, Theresa B Loveless, Joseph H. Grotts, Chang C. Liu, Courtney K. Carlson, Xiaohui Xie, Guohao Liang, Beide Liu, Bijan S. Agahi
Publikováno v:
Nature chemical biology, vol 17, iss 6
Nat Chem Biol
Nat Chem Biol
Studying cellular and developmental processes in complex multicellular organisms can require the non-destructive observation of thousands to billions of cells deep within an animal. DNA recorders address the staggering difficulty of this task by conv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7ba44077e89c8b13b96bbcf17a64cf
https://escholarship.org/uc/item/9jw206v6
https://escholarship.org/uc/item/9jw206v6
Autor:
Richard L. Gallo, Marc C. Liggins, Tatsuya Dokoshi, George L. Sen, Teruaki Nakatsuji, Yu Sawada, Nikhil Nitin Kulkarni
Publikováno v:
Science immunology, vol 6, iss 59
Sci Immunol
Sci Immunol
The skin typically tolerates exposure to various microbes and chemicals in the environment. Here, we investigated how the epidermis maintains this innate immune tolerance to stimuli that are recognized by Toll-like receptors (TLRs). Loss of tolerance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d149e8175df57a15b8d0016b8ea81ccc
https://escholarship.org/uc/item/5db3p8h5
https://escholarship.org/uc/item/5db3p8h5
Autor:
Sulabha Argade, Hong Xin, Biswa Choudhury, Anastasia Chilla, Napoleone Ferrara, Brian P. Eliceiri, Wei Liang, Pin Li, Lixian Liu, Cuiling Zhong
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Endothelial cell (EC) metabolism is thought to be one of the driving forces for angiogenesis. Here we report the identification of the hexosamine D-mannosamine (ManN) as an EC mitogen and survival factor for bovine and human microvascular EC, with an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e2a22bcd95cfd25a21c5a69367fa75
https://escholarship.org/uc/item/7m15v0q9
https://escholarship.org/uc/item/7m15v0q9
Autor:
Yao-Hui Sun, Regan Smithers, Hillary K.J. Kao, Padmini Sirish, Che-Wei Chang, Dalyir I. Pretto, James W. Chan, Sergey Yechikov, Xiao-Dong Zhang, Deborah K. Lieu, Jan A. Nolta, Nipavan Chiamvimonvat
Publikováno v:
Stem cell research
Stem Cell Research, Vol 49, Iss, Pp 102043-(2020)
Stem Cell Research, Vol 49, Iss, Pp 102043-(2020)
Directed cardiomyogenesis from human induced pluripotent stem cells (hiPSCs) has been greatly improved in the last decade but directed differentiation to pacemaking cardiomyocytes (CMs) remains incompletely understood. In this study, we demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2e2ed1ba35deff14f7cfdfd843d2f7
https://escholarship.org/uc/item/6v78x8d7
https://escholarship.org/uc/item/6v78x8d7
Autor:
Arnold R. Kriegstein, Ming Hu, Ugomma C. Eze, Michael Song, Changxu Fan, Ian Jones, Ivan Juric, Lenka Maliskova, Yin Shen, Mayank N. K. Choudhary, Ting Wang, Jerry Lee, Bingkun Li, Seth Bergenholtz, Mark-Phillip Pebworth, Jia Wen, Yun Li, Armen Abnousi, Xiekui Cui, Weifang Liu, Alex A. Pollen, Jonathan D. Rosen, Xiaoyu Yang
Publikováno v:
Nature, vol 587, iss 7835
Nature
Nature
Lineage-specific epigenomic changes during human corticogenesis have remained elusive due to challenges with sample availability and tissue heterogeneity. For example, previous studies used single-cell RNA sequencing to identify at least nine major c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a644c262ff83307505111efd951970
https://escholarship.org/uc/item/9x4848qd
https://escholarship.org/uc/item/9x4848qd
Autor:
Yang Hu, George M. Smith, Yue Sun, Hey-Kyeong Jeong, Kaitlin M. Collura, Jingwen Niu, Sabrina M. Holland, Luiselys M. Hernandez, Yishi Jin, Gareth M. Thomas, Shaun S. Sanders, Haoliang Huang, Michael R. Hayden
Publikováno v:
Cell reports, vol 33, iss 7
Cell Reports, Vol 33, Iss 7, Pp 108365-(2020)
Cell reports
Cell Reports, Vol 33, Iss 7, Pp 108365-(2020)
Cell reports
SUMMARY After optic nerve crush (ONC), the cell bodies and distal axons of most retinal ganglion cells (RGCs) degenerate. RGC somal and distal axon degenerations were previously thought to be controlled by two parallel pathways, involving activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d8ca0dca498d31c5f9ebd64ba1441f
https://escholarship.org/uc/item/97f3m57t
https://escholarship.org/uc/item/97f3m57t
Publikováno v:
The Journal of investigative dermatology, vol 140, iss 11
J Invest Dermatol
J Invest Dermatol
p63 is expressed from two promoters and produces two N-terminal isoforms, TAp63 and ΔNp63. Alternative splicing creates three C-terminal isoforms p63α, p63β, and p63δ, whereas alternative polyadenylation (APA) in coding sequence creates two more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685ddd6a2f7b8720f923140d5026c294
https://escholarship.org/uc/item/8dn5q6n7
https://escholarship.org/uc/item/8dn5q6n7
Publikováno v:
Scientific reports, vol 10, iss 1
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Ca2+ release-activated Ca2+ (CRAC) channels elevate cytoplasmic Ca2+ concentration, which is essential for T cell activation, differentiation and effector functions. T cell receptor stimulation induces depletion of the endoplasmic reticulum (ER) Ca2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4e9863e948ad94f8fe120fc10f9426
https://escholarship.org/uc/item/6nd0b6t5
https://escholarship.org/uc/item/6nd0b6t5