Zobrazeno 1 - 10
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Publikováno v:
J Mol Cell Cardiol
Since the initial isolation of human embryonic stem cells and subsequent discovery of reprogramming methods for somatic cells, thousands of protocols have been developed to create each of the hundreds of cell types found in-vivo with significant focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81c15000810c1ee24eded95cdbe7db1
https://escholarship.org/uc/item/6sp868hn
https://escholarship.org/uc/item/6sp868hn
Publikováno v:
Biochem Pharmacol
The Hedgehog (Hh) family of lipid-modified signaling proteins directs embryonic tissue patterning and postembryonic tissue homeostasis, and dysregulated Hh signaling drives familial and sporadic cancers. Hh ligands bind to and inhibit the tumor suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e41d47683cea1a2be693eb6730efed
https://escholarship.org/uc/item/1jh7c8jg
https://escholarship.org/uc/item/1jh7c8jg
Autor:
Hannah A. Ledford, Euan A. Ashley, Aiyana M. Emigh, Xiao-Dong Zhang, Phung N. Thai, Lu Ren, Ebenezer N. Yamoah, Valeriy Timofeyev, Wilson Xu, Seojin Park, Padmini Sirish, James R. Priest, Marco V Perez, Vladimir Yarov-Yarovoy, Nipavan Chiamvimonvat
Publikováno v:
Heart rhythm, vol 19, iss 2
Heart Rhythm
Heart Rhythm
BACKGROUND: Long QT syndrome (LQTS) is a hereditary disease that predisposes patients to life-threatening cardiac arrhythmias and sudden cardiac death. Our previous study of the human ether-à-go-go related gene (hERG)–encoded K(+) channel (K(v)11.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d31dc902781adcee43810bec8cced5
https://escholarship.org/uc/item/2z32234h
https://escholarship.org/uc/item/2z32234h
Publikováno v:
RNA (New York, N.Y.), vol 27, iss 12
RNA
RNA
DDX3 is a DEAD-box RNA helicase that regulates translation and is encoded by the X- and Y-linked paralogsDDX3XandDDX3Y. While DDX3X is ubiquitously expressed in human tissues and essential for viability, DDX3Y is male-specific and shows lower and mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dec65a28f7797b3069dc3f648130932
https://escholarship.org/uc/item/4zr6x7w0
https://escholarship.org/uc/item/4zr6x7w0
Autor:
Wayne W. Poon, Karen H. Gylys, Ryan C. Bohannan, Emily Miyoshi, Harry V. Vinters, Carol A. Miller, Maria M. Corrada, Tina Bilousova, Mikhail Melnik, Varghese John, Jesus Campagna, Chris Jean Elias, Danyl Fakhrutdinov, Claudia H. Kawas, Katherine N. Maina, Chad A. Caraway
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology, vol 101, iss 12
Laboratory Investigation; a Journal of Technical Methods and Pathology
Laboratory Investigation; a Journal of Technical Methods and Pathology
Synaptic transfer of tau has long been hypothesized from the human pathology pattern and has been demonstrated in vitro and in vivo, but the precise mechanisms remain unclear. Extracellular vesicles such as exosomes have been suggested as a mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80152dcbf6f9b69c208548360236f071
https://escholarship.org/uc/item/7400c6qs
https://escholarship.org/uc/item/7400c6qs
Autor:
Louise C. Laurent, Mariko Horii, Mana M. Parast, Hee Young Cho, Robert Morey, Hannah Rishik, Katharine K. Nelson, Tony Bui, Ojeni Touma
Publikováno v:
Scientific Reports, vol 11, iss 1
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder, affecting up to 10% of pregnancies worldwide. The primary etiology is considered to be abnormal development and function of placental cells called trophoblasts. We previously developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7c37dcca19344e05a3ef8f648d7d01
https://escholarship.org/uc/item/2cv8r41c
https://escholarship.org/uc/item/2cv8r41c
ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages
Autor:
Emilie Barruet, Edward C. Hsiao, Ashley Pereira, Amy N. Ton, Robert Dalton Chavez, Judith Hellman, Koji Matsuo, Aditi Sharma, Abigail Lepinski, Mary C. Nakamura, Tania Moody, Kiichiro Tomoda
Publikováno v:
Bone
Macrophages play crucial roles in many human disease processes. However, obtaining large numbers of primary cells for study is often difficult. We describe 2D and 3D methods for directing human induced pluripotent stem cells (hiPSCs) into macrophages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a459adf8af853d372f3236392ca08011
https://escholarship.org/uc/item/9bn0c1hc
https://escholarship.org/uc/item/9bn0c1hc
Autor:
Heather S. McKay, Steven Kopcho, Hussein Kaddour, Marta Epeldegui, Eun Young Kim, Chioma M. Okeoma, Nadia Shouman, Victor Paromov, Jack T. Stapleton, Yuan Lyu, Joseph B. Margolick, Siddharth Pratap, Chandravanu Dash, Jeremy J. Martinson
Publikováno v:
Cellular and molecular life sciences : CMLS, vol 79, iss 1
Cell Mol Life Sci
Cell Mol Life Sci
Background: Extracellular vesicles (EVs) are mediators of horizontal transfer of bioactive molecules between cells and regulators of cell-cell interaction. EV-mediated cell-cell interactions play roles in physiological and pathophysiological conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0544118d91c691a3642df4ee68e4a9ce
https://escholarship.org/uc/item/18t771qv
https://escholarship.org/uc/item/18t771qv
Autor:
Anaïs Anton, Berati Cerikan, Laurent Chatel-Chaix, Felix Pahmeier, Aïssatou Aïcha Sow, Ralf Bartenschlager, Clément Mazeaud, Mirko Cortese, Wesley Freppel
Publikováno v:
Viruses, vol 13, iss 10
Viruses, Vol 13, Iss 2092, p 2092 (2021)
Viruses
Volume 13
Issue 10
Viruses, Vol 13, Iss 2092, p 2092 (2021)
Viruses
Volume 13
Issue 10
The dengue virus (DENV) causes the most prevalent arthropod-borne viral disease worldwide. While its incidence is increasing in many countries, there is no approved antiviral therapy currently available. In infected cells, the DENV induces extensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5eadadac322afb2c5a7b3e1a7b589b2
https://escholarship.org/uc/item/77k8z1x7
https://escholarship.org/uc/item/77k8z1x7
Publikováno v:
Cell metabolism, vol 33, iss 9
Cell Metab
Cell Metab
Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted, exosomes gain access to the interstitial space and ultimately the circulation, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99179ef091c2ebd0623924ac9cb70da
https://escholarship.org/uc/item/5cr8h1vx
https://escholarship.org/uc/item/5cr8h1vx