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Autor:
Elliot Naidus, Lawrence Fong, David Y. Oh, Nathan Standifer, Jerome Bouquet, Timothy Looney, Li Zhang, Hai Yang
Publikováno v:
Cancer immunology, immunotherapy : CII, vol 70, iss 7
Cancer Immunology, Immunotherapy
Cancer Immunology, Immunotherapy
Immune checkpoint inhibitors (ICI) are designed to activate exhausted tumor-reactive T cells thereby leading to tumor regression. Durvalumab, an ICI that binds to the programmed death ligand-1 (PD-L1) molecule, is approved as a consolidation therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81755443fe7b823829672ac3b3048c5d
https://escholarship.org/uc/item/53t0g7b0
https://escholarship.org/uc/item/53t0g7b0
Autor:
Leonel Hernandez-Aya, Saby George, Shivaani Kummar, Leisha A. Emens, Andrew Hotson, Joshua Brody, Ben Markman, Dale R. Shepard, Daruka Mahadevan, Jonathan W. Goldman, Matthew D. Hellmann, Brian Munneke, Daniel J. Renouf, Lawrence Fong, Richard A. Miller, Lyudmyla Berim, Jason J. Luke, Mario Sznol, Amy Weise, Stephen Willingham, Ian McCaffery, Rebecca S. Heist, John D. Powderly, Toni K. Choueiri, Long Kwei, Matthew J. Riese, Po Y. Ho, Ginna G. Laport, Brian I. Rini, Jessica Hsieh, Philip Bonomi, Rachel Anne Goodwin, Brett G.M. Hughes
Publikováno v:
Cancer discovery, vol 10, iss 1
Adenosine mediates immunosuppression within the tumor microenvironment through triggering adenosine 2A receptors (A2AR) on immune cells. To determine whether this pathway could be targeted as an immunotherapy, we performed a phase I clinical trial wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75de947792f88bb354890c23b61fe49
https://escholarship.org/uc/item/3vq7n8qs
https://escholarship.org/uc/item/3vq7n8qs
Autor:
Kian H. Lim, Jeffrey S. Morris, Sadakatsu Ikeda, Hesham M. Amin, Kenna R. Mills-Shaw, Funda Meric-Bernstam, Ahmed Kaseb, Robin Kate Kelley, Benjamin R. Tan, Bhawana George, Lianchun Xiao, Marc Uemura, Andrea Grace Bocobo, Richard B. Lanman, Razelle Kurzrock, Manal M. Hassan, James C. Yao, Robert A. Wolff, Reham Abdel-Wahab, Wei Qiao, Shiraj Sen, Abedul Haque, Asif Rashid, Nora S. Sanchez, Kanwal Pratap Singh Raghav, Kimberly C. Banks, Roberto Carmagnani Pestana, Amir Ali Talasaz
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 25, iss 20
Clin Cancer Res
Clin Cancer Res
Purpose: Molecular profiling has been used to select patients for targeted therapy and determine prognosis. Noninvasive strategies are critical to hepatocellular carcinoma (HCC) given the challenge of obtaining liver tissue biopsies. Experimental Des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea41216438d763f99cc814dcd6c4ae02
https://escholarship.org/uc/item/51m038zw
https://escholarship.org/uc/item/51m038zw
Autor:
Tsu Yi Chao, Manuel Modiano, Wei Peng Yong, Jung Hwan Yoon, Bradley Freilich, Baek Yeol Ryoo, Thomas Yau, Ho Yeong Lim, Chia-Chi Lin, Imane El Dika, Robin Kate Kelley, Jennifer J. Knox, Joanne Brown, Hye Jin Choi, Ghassan K. Abou-Alfa
Publikováno v:
The oncologist, vol 24, iss 6
The Oncologist
The Oncologist
Lessons LearnedTKM-080301 showed a favorable toxicity profile at the studied dose. TKM-080301 targeting PLK1 through small interfering RNA mechanism did not demonstrate improved overall survival in patients with advanced hepatocellular carcinoma comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb3a2ba925474601c76c11bcf09513f
https://escholarship.org/uc/item/6tw9j1m8
https://escholarship.org/uc/item/6tw9j1m8
Autor:
Shumei Kato, Ryosuke Okamura, Gregory A. Daniels, Garrett M. Frampton, Vincent A. Miller, Aaron M. Goodman, Ranajoy Chattopadhyay, Razelle Kurzrock, Ila M Saunders, Meagan Montesion
Publikováno v:
Cancer immunology research, vol 7, iss 6
Cancer Immunol Res
Cancer Immunol Res
Advanced and metastatic squamous cell carcinomas (SCC) are common and difficult-to-treat malignancies. We assessed 75 immunotherapy-treated patients with SCC from a clinically annotated database of 2,651 patients, as well as 9,407 patients from a dei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfbfe2b5f1b3756f8b8a68f5b7f8e7c
https://escholarship.org/uc/item/9s65n78h
https://escholarship.org/uc/item/9s65n78h
Publikováno v:
Clinical epigenetics, vol 10, iss 1
Clinical Epigenetics
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-11 (2018)
Clinical Epigenetics
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-11 (2018)
Background Elucidation of epigenetic alterations in bladder cancer will lead to further understanding of the biology of the disease and hopefully improved therapies. Our aim was to perform an integrative epigenetic analysis of invasive urothelial car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5530ed352e5a280f0b22548e1ccbd60
https://escholarship.org/uc/item/6xk8r7dt
https://escholarship.org/uc/item/6xk8r7dt
Autor:
Francis Y. Yao, David D. Lee, Paul D. Greig, Julie K. Heimbach, John P. Roberts, Neil Mehta, William Sanchez, Jennifer L. Dodge, Denise M. Harnois, Justin M. Burns, David R. Grant, Gonzalo Sapisochin
Publikováno v:
JAMA oncology, vol 3, iss 4
ImportanceSeveral factors are associated with increased hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT), but no reliable risk score has been established to determine the individual risk for HCC recurrence.ObjectiveWe aimed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839f63929b1f3c7b113639b0c0725f5f
https://escholarship.org/uc/item/5qq9k9mb
https://escholarship.org/uc/item/5qq9k9mb
Autor:
Missak Haigentz, Tianhong Li, Mimi Kim, Primo N. Lara, Huiyu Wen, Laurel A. Beckett, Bilal Piperdi, Xianhong Xie, Srikanth Gajavelli, Kaili Zhou, William V. Walsh, Patricia Pasquinelli, Meera Sreedhara, Roman Perez-Soler, Venu Bathini, David R. Gandara, Rasim Gucalp
Publikováno v:
Clinical lung cancer, vol 18, iss 1
Li, T; Piperdi, B; Walsh, WV; Kim, M; Beckett, LA; Gucalp, R; et al.(2017). Randomized Phase 2 Trial of Pharmacodynamic Separation of Pemetrexed and Intercalated Erlotinib Versus Pemetrexed Alone for Advanced Nonsquamous, Non–small-cell Lung Cancer. Clinical Lung Cancer, 18(1), 60-67. doi: 10.1016/j.cllc.2016.10.003. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/8v79g597
Li, T; Piperdi, B; Walsh, WV; Kim, M; Beckett, LA; Gucalp, R; et al.(2017). Randomized Phase 2 Trial of Pharmacodynamic Separation of Pemetrexed and Intercalated Erlotinib Versus Pemetrexed Alone for Advanced Nonsquamous, Non–small-cell Lung Cancer. Clinical Lung Cancer, 18(1), 60-67. doi: 10.1016/j.cllc.2016.10.003. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/8v79g597
© 2016 This randomized phase 2 study demonstrated promising clinical synergism between pemetrexed and intercalated erlotinib in patients with unselected nonsquamous non–small-cell lung cancer (NSCLC) as second-line therapy. EGFR (epidermal growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc695b9f3ff6d72a8b7af4e2f474fd91
https://escholarship.org/uc/item/8v79g597
https://escholarship.org/uc/item/8v79g597
Publikováno v:
Breast Cancer Research and Treatment, vol 157, iss 2
Breast cancer research and treatment, vol 157, iss 2
Molinaro, AM; Sison, JD; Ljung, B-M; Tlsty, TD; & Kerlikowske, K. (2016). Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy. BREAST CANCER RESEARCH AND TREATMENT, 157(2), 351-361. doi: 10.1007/s10549-016-3814-z. UCSF: Retrieved from: http://www.escholarship.org/uc/item/5k39q1kt
Breast cancer research and treatment, vol 157, iss 2
Molinaro, AM; Sison, JD; Ljung, B-M; Tlsty, TD; & Kerlikowske, K. (2016). Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy. BREAST CANCER RESEARCH AND TREATMENT, 157(2), 351-361. doi: 10.1007/s10549-016-3814-z. UCSF: Retrieved from: http://www.escholarship.org/uc/item/5k39q1kt
Among women diagnosed with ductal carcinoma in situ (DCIS), we identified factors associated with local invasive cancer (LIC) and regional/metastatic invasive cancer (RMIC) and provide 10-year risks based on clinically relevant factors. We created a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0083a78c193c20e3cf8579be4443b2e
https://escholarship.org/uc/item/5t46p8td
https://escholarship.org/uc/item/5t46p8td
Publikováno v:
Clinical lung cancer, vol 17, iss 1
Background The role of intensity-modulated radiotherapy (IMRT) in reducing treatment-related toxicity for locally advanced non–small-cell lung cancer (NSCLC) remains incompletely defined. We compared acute toxicity and oncologic outcomes in a large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2047691b5fd99cdb16cd44e068e0b04
https://escholarship.org/uc/item/74q8m5f9
https://escholarship.org/uc/item/74q8m5f9