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Pompe disease is an autosomal recessive lysosomal storage disease caused by pathogenic variants in GAA, which encodes an enzyme integral to glycogen catabolism, acid α-glucosidase. Disease-relevant cell lines are necessary to evaluate the efficacy o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674f754760e8b128a21849e99b836d3a
https://escholarship.org/uc/item/4ds0566v
https://escholarship.org/uc/item/4ds0566v
Autor:
Chengsheng Wu, Taha Rakhshandehroo, Hiromi I. Wettersten, Alejandro Campos, Tami von Schalscha, Shashi Jain, Ziqi Yu, Jiali Tan, Evangeline Mose, Betzaira G. Childers, Andrew M. Lowy, Sara M. Weis, David A. Cheresh
Publikováno v:
Nature cell biology, vol 25, iss 2
Nat Cell Biol
Nat Cell Biol
Defining drivers of tumour initiation can provide opportunities to control cancer progression. Here we report that lysophosphatidic acid receptor 4 (LPAR4) becomes transiently upregulated on pancreatic cancer cells exposed to environmental stress or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7183f74989b8a5e50b8abbec1e8ef4a
https://escholarship.org/uc/item/3xs321vw
https://escholarship.org/uc/item/3xs321vw
Autor:
Yoshihiro Ishikawa, Yuki Taga, Thibault Coste, Sara F. Tufa, Douglas R. Keene, Kazunori Mizuno, Elisabeth Tournier-Lasserve, Douglas B. Gould
Publikováno v:
The Journal of biological chemistry, vol 298, iss 12
Collagens are the most abundant proteins in the body and among the most biosynthetically complex. A molecular ensemble of over 20 endoplasmic reticulum resident proteins participates in collagen biosynthesis and contributes to heterogeneous post-tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbeff3dfb1980b0d8730a3cad73f362
https://escholarship.org/uc/item/0gs5w663
https://escholarship.org/uc/item/0gs5w663
Autor:
Daniel Q, Huang, Amit G, Singal, Yuko, Kono, Darren J H, Tan, Hashem B, El-Serag, Rohit, Loomba
Publikováno v:
Cell metabolism, vol 34, iss 7
Cell Metab
Cell Metab
Liver cancer epidemiology is changing due to increasing alcohol consumption, rising prevalence of obesity, and advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) treatment. However, the impact of these changes on global liver cancer burd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695b5f385014c5987a9f850e71874612
https://escholarship.org/uc/item/49h8k4rz
https://escholarship.org/uc/item/49h8k4rz
Autor:
Wei Yan, Minghui Cao, Xianhui Ruan, Li Jiang, Sylvia Lee, Adriana Lemanek, Majid Ghassemian, Donald P. Pizzo, Yuhao Wan, Yueqing Qiao, Andrew R. Chin, Erika Duggan, Dong Wang, John P. Nolan, Jeffrey D. Esko, Simon Schenk, Shizhen Emily Wang
Publikováno v:
Nature cell biology, vol 24, iss 5
A decline in skeletal muscle mass and low muscular strength are prognostic factors in advanced human cancers. Here we found that breast cancer suppressed O-linked N-acetylglucosamine (O-GlcNAc) protein modification in muscle through extracellular-ves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8241931457664538dc22b4bb47a626
https://escholarship.org/uc/item/0qp585kz
https://escholarship.org/uc/item/0qp585kz
Autor:
Jaymin J. Kathiriya, Chaoqun Wang, Minqi Zhou, Alexis Brumwell, Monica Cassandras, Claude Jourdan Le Saux, Max Cohen, Kostantinos-Dionysios Alysandratos, Bruce Wang, Paul Wolters, Michael Matthay, Darrell N. Kotton, Harold A. Chapman, Tien Peng
Publikováno v:
Nature cell biology, vol 24, iss 1
Loss of alveolar type 2 cells (AEC2s) and the ectopic appearance of basal cells in the alveoli characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we demonstrate that human alveolar type 2 cells (hAEC2s), unlike murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a23d5ce0833a4e930fbaf6763f481b
https://escholarship.org/uc/item/2qh206wf
https://escholarship.org/uc/item/2qh206wf
ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages
Autor:
Emilie Barruet, Edward C. Hsiao, Ashley Pereira, Amy N. Ton, Robert Dalton Chavez, Judith Hellman, Koji Matsuo, Aditi Sharma, Abigail Lepinski, Mary C. Nakamura, Tania Moody, Kiichiro Tomoda
Publikováno v:
Bone
Macrophages play crucial roles in many human disease processes. However, obtaining large numbers of primary cells for study is often difficult. We describe 2D and 3D methods for directing human induced pluripotent stem cells (hiPSCs) into macrophages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a459adf8af853d372f3236392ca08011
https://escholarship.org/uc/item/9bn0c1hc
https://escholarship.org/uc/item/9bn0c1hc
Autor:
Anaïs Anton, Berati Cerikan, Laurent Chatel-Chaix, Felix Pahmeier, Aïssatou Aïcha Sow, Ralf Bartenschlager, Clément Mazeaud, Mirko Cortese, Wesley Freppel
Publikováno v:
Viruses, vol 13, iss 10
Viruses, Vol 13, Iss 2092, p 2092 (2021)
Viruses
Volume 13
Issue 10
Viruses, Vol 13, Iss 2092, p 2092 (2021)
Viruses
Volume 13
Issue 10
The dengue virus (DENV) causes the most prevalent arthropod-borne viral disease worldwide. While its incidence is increasing in many countries, there is no approved antiviral therapy currently available. In infected cells, the DENV induces extensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5eadadac322afb2c5a7b3e1a7b589b2
https://escholarship.org/uc/item/77k8z1x7
https://escholarship.org/uc/item/77k8z1x7
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 40
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Membrane-associated mucins protect epithelial cell surfaces against pathogenic threats by serving as nonproductive decoys that capture infectious agents and clear them from the cell surface and by erecting a physical barrier that restricts their acce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57082dd4cc60c62f8c1c770486e3f34
https://escholarship.org/uc/item/341956rm
https://escholarship.org/uc/item/341956rm
Publikováno v:
Cell reports, vol 36, iss 3
Cell reports
Cell reports
SUMMARY Spermatogonial stem cells (SSCs) are essential for male fertility. Here, we report that mouse SSC generation is driven by a transcription factor (TF) cascade controlled by the homeobox protein, RHOX10, which acts by driving the differentiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89659c747d788efd887ed4d6115d6a9c
https://escholarship.org/uc/item/85x0765v
https://escholarship.org/uc/item/85x0765v