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Publikováno v:
Haemophilia : the official journal of the World Federation of Hemophilia, vol 27, iss 4
Haemophilia
Haemophilia
AimPhase 2b study to assess efficacy, safety, thrombogenicity, immunogenicity and tolerability with 28days of daily dosing of subcutaneous (SQ) dalcinonacog alfa as prophylaxis for haemophilia B (HB).MethodsAdult males with a confirmed diagnosis of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541b33ba0a83fb581ee23a7322f35a6a
https://escholarship.org/uc/item/6hf7d0wc
https://escholarship.org/uc/item/6hf7d0wc
Autor:
Christopher R. Nicholas, Keren Tzarfaty, Ann T Mithoefer, Ray Worthy, Amy Emerson, Simon Amar, Charlotte Harrison, Sarah Kleiman, Ingmar Gorman, Kelly Parker-Guilbert, Michael P. Bogenschutz, Sukhpreet S. Klaire, Alberdina de Boer, Emma Hapke, Bessel A. van der Kolk, Berra Yazar-Klosinski, Michael C. Mithoefer, Allison R. Coker, Rick Doblin, Cole Marta, Wael Garas, Jennifer M. Mitchell, Scott Hamilton, Sylvestre Quevedo, Rebecca Matthews, Yair Wallach, G. M. Wells, Marcela Ot’alora G., Randall Brown, Bruce Poulter, Joshua D. Woolley, Yevgeniy Gelfand, Casey Paleos, Shannon Carlin, Scott Shannon, Alia Lilienstein, Revital Amiaz, Julie B. Wang
Publikováno v:
Nature medicine, vol 27, iss 6
Post-traumatic stress disorder (PTSD) presents a major public health problem for which currently available treatments are modestly effective. We report the findings of a randomized, double-blind, placebo-controlled, multi-site phase 3 clinical trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b51eadf9452e201a5e59273668aa143
https://escholarship.org/uc/item/9pm86760
https://escholarship.org/uc/item/9pm86760
Autor:
Anne E. Purfield, Nigel A. Scott, Samuel Pierre, Madeleine Lourens, Richard E. Chaisson, Melissa Engle, Payam Nahid, Erin Sizemore, Patrick P. J. Phillips, Ziyaad Waja, Kelly E. Dooley, Susan Swindells, Marc H Weiner, Ekaterina V. Kurbatova, Kim Narunsky, Radojka M. Savic, Susan E. Dorman, Sandy Nerette, Nhung Viet Nguyen, Wadzanai Samaneka, Ha T.T. Phan, James Hakim, Andrew Vernon, Thuong H. Pham, Grace Muzanyi, Stefan V. Goldberg, Justin Shenje, John L. Johnson, Neil A. Martinson, Kia E Bryant, Ian Sanne
Publikováno v:
The New England journal of medicine, vol 384, iss 18
BackgroundRifapentine-based regimens have potent antimycobacterial activity that may allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis.MethodsIn an open-label, phase 3, randomized, controlled trial involving persons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3229ece147fe062e786e2a34a8ab15fd
https://escholarship.org/uc/item/30c34231
https://escholarship.org/uc/item/30c34231
Autor:
Lorenzo Del Sorbo, Atul Malhotra, Larry Tsai, Helen Spotswood, Ronaldo C. Go, Ivan O. Rosas, Taryn Youngstein, Norbert Bräu, Andrew Ustianowski, Sanjay Bhagani, Min Bao, Sophie Dimonaco, Mariam Aziz, Nichola Cooper, Bradley D Hunter, David J. De La Zerda, Michael F. Waters, Daniel Skiest, Emily Graham, Sinisa Savic, Antonio Cubillo Gracian, Balpreet Matharu, Ivor S. Douglas
Publikováno v:
The New England journal of medicine, vol 384, iss 16
Background Coronavirus disease 2019 (Covid-19) is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal antibody against the interleukin-6 receptor, has resulted in b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b63ca1c20584d448f33fd98ff7b410f
https://escholarship.org/uc/item/36k8m3wp
https://escholarship.org/uc/item/36k8m3wp
Autor:
Anup Patel, Jean-Francois Martini, Bernard Escudier, Xun Lin, Robert J. Motzer, Alain Ravaud, Daniel J. George, Allan J. Pantuck, Michael Staehler, Mariajose Lechuga
Publikováno v:
Future oncology (London, England), vol 17, iss 4
Future Oncology
Future Oncology
Aim: To examine the prognostic value of the platelet-to-lymphocyte ratio (PLR) in the adjuvant renal cell carcinoma setting. Materials & methods: Patients received adjuvant sunitinib (50 mg/day; 4 weeks on/2 weeks off) or placebo. The primary end poi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa719a0144154a8e54bb767da530cdf
https://escholarship.org/uc/item/7tp3w44v
https://escholarship.org/uc/item/7tp3w44v
Autor:
Noor Khalid, Razelle Kurzrock, Jacob J. Adashek, Suzanna Lee, Shumei Kato, Jason K. Sicklick, Van Thomas Nguyen, Ryosuke Okamura
Publikováno v:
JCI insight, vol 6, iss 1
JCI Insight, Vol 6, Iss 1 (2021)
JCI Insight
JCI Insight, Vol 6, Iss 1 (2021)
JCI Insight
BACKGROUND Although CDK4/6 inhibitors are an established treatment for hormone receptor–positive, HER2-negative metastatic breast cancers, their benefit in other malignancies remains limited.METHODS We investigated factors associated with clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66de530f4ac6efbc82971e89d868547b
https://escholarship.org/uc/item/66p2z8d2
https://escholarship.org/uc/item/66p2z8d2
Autor:
Ira T. Lott, Benjamin Tycko, Juan Fortea, Benjamin L. Handen, Nicole Schupf, Shahid Zaman, Melissa E. Petersen, Fan Zhang, Mei-Cheng Wang, H. Diana Rosas, Elizabeth Head, Michael S. Rafii, Florence Lai, James Hall, Mark Mapstone, Joseph H. Lee, Sid E. O'Bryant, Beau M. Ances, Sharon J. Krinsky-McHale, William E. Klunk, Sigan L. Hartley, Tatiana Foroud, David Julovich, Brad T. Christian, Wayne Silverman
Publikováno v:
Journal of Alzheimer's disease : JAD, vol 79, iss 2
J Alzheimers Dis
JOURNAL OF ALZHEIMERS DISEASE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Fundacion Sancho el Sabio Fundazioa (FSS)
J Alzheimers Dis
JOURNAL OF ALZHEIMERS DISEASE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Fundacion Sancho el Sabio Fundazioa (FSS)
BackgroundThe need for diagnostic biomarkers of cognitive decline is particularly important among aging adults with Down syndrome (DS). Growing empirical support has identified the utility of plasma derived biomarkers among neurotypical adults with m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece812cd66a619d971c8dfee56d29083
https://escholarship.org/uc/item/6wb905q1
https://escholarship.org/uc/item/6wb905q1
Autor:
Koen Paemeleire, Jo H. Bonner, Jelena M. Pavlovic, Feng Zhang, Alan M. Rapoport, H. Gobel, Daniel D. Mikol, Hernan Picard, Risa Kagan
Publikováno v:
The journal of headache and pain, vol 21, iss 1
The Journal of Headache and Pain, Vol 21, Iss 1, Pp 1-9 (2020)
The Journal of Headache and Pain
JOURNAL OF HEADACHE AND PAIN
The Journal of Headache and Pain, Vol 21, Iss 1, Pp 1-9 (2020)
The Journal of Headache and Pain
JOURNAL OF HEADACHE AND PAIN
Background We performed a post hoc, subgroup analysis of a phase 3, randomized, double-blind, placebo-controlled study of erenumab for prevention of episodic migraine (STRIVE) to determine the efficacy and safety of erenumab in women with self-report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a5f176d69f7e7b86a765585b51edff
https://escholarship.org/uc/item/95x8t7hv
https://escholarship.org/uc/item/95x8t7hv
Autor:
Sara J. Newmann, Hilary Reno, Jonathan D. Powell, Audrey L. French, Craig R. Cohen, Sheldon R. Morris, Lauri Green, Steve Miller, Anke Hemmerling, Thomas P. Parks, Michael R. Wierzbicki
Publikováno v:
The New England journal of medicine, vol 382, iss 20
N Engl J Med
N Engl J Med
BACKGROUND: Bacterial vaginosis affects 15 to 50% of women of reproductive age, and recurrence is common after treatment with an antibiotic agent. The high incidence of recurrence suggests the need for new treatments to prevent recurrent bacterial va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7207377d775a093b2ed2bee2ce151b47
https://escholarship.org/uc/item/63d236n5
https://escholarship.org/uc/item/63d236n5
Autor:
Julie Low, Florin Vaida, Sara H. Browne, Kathleen Moser, Jonathan Gonzalez Garcia, Constance A. Benson, Anya Umlauf, Amanda J. Tucker, Terrence F. Blaschke, Charles A. Peloquin
Publikováno v:
PLoS medicine, vol 16, iss 10
PLoS Medicine, Vol 16, Iss 10, p e1002891 (2019)
PLoS Medicine, Vol 16, Iss 10, p e1002891 (2019)
BackgroundExcellent adherence to tuberculosis (TB) treatment is critical to cure TB and avoid the emergence of resistance. Wirelessly observed therapy (WOT) is a novel patient self-management system consisting of an edible ingestion sensor (IS), exte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba44b17d75bdbbcc94f196fcea7f6b42
https://escholarship.org/uc/item/8bw056pd
https://escholarship.org/uc/item/8bw056pd