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Publikováno v:
The Journal of biological chemistry, vol 297, iss 5
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Unique among metazoan repressive histone methyltransferases, G9a and GLP, which chiefly target histone 3 lysine 9 (H3K9), require dimerization for productive H3K9 mono (me1)- and dimethylation (me2) invivo. Intriguingly, even though each enzyme can i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000f989643cd92bff494c1b9a5f79ee5
https://escholarship.org/uc/item/0nm6s474
https://escholarship.org/uc/item/0nm6s474
Autor:
Fengchun Zhang, Carlo Selmi, William M. Ridgway, M. Eric Gershwin, Zhilei Chen, Patrick S.C. Leung, Weici Zhang
Publikováno v:
Autoimmunity reviews, vol 20, iss 11
Autoimmun Rev
Autoimmun Rev
The myristoylated alanine-rich C-kinase substrate (MARCKS) and the MARCKS-related protein (MARCKSL1) are ubiquitous, highly conserved membrane-associated proteins involved in the structural modulation of the actin cytoskeleton, chemotaxis, motility,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e814541a33d417c11aff5866ad7b18b
https://escholarship.org/uc/item/0tq1f7hk
https://escholarship.org/uc/item/0tq1f7hk
Publikováno v:
Nature reviews. Immunology, vol 21, iss 11
Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and malignant cells and can provide long-term protective immunity. In the response to infection, CD8+ T cell metabolism is coupled to transcriptional, translational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de632eac1b1397241c357281c4512aa
https://escholarship.org/uc/item/1n49006c
https://escholarship.org/uc/item/1n49006c
Autor:
Jianqin Niu, Feng Mei, Stephen P.J. Fancy, Jonah R. Chan, Yuxin Wang, Xiaorui Wang, Lan Xiao, Guangdan Yu, Wenlong Xia, Kimberly K. Hoi
Publikováno v:
Neuron, vol 109, iss 19
Neuron
Neuron
Oligodendrocyte (OL) maturation arrest in human white matter injury contributes significantly to the failure of endogenous remyelination in multiple sclerosis (MS) and newborn brain injuries such as hypoxic ischemic encephalopathy (HIE) that cause ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcda9c045c5e743d6b62f22d0884c57e
https://escholarship.org/uc/item/9vb4k2nx
https://escholarship.org/uc/item/9vb4k2nx
Autor:
Caiyong Ye, Anja Katrin Bielinsky, Bing Xia, Zhihua Kang, Yamei Zuo, Pan Fu, Mirit I. Aladjem, Ryan M. Baxley, Christophe E. Redon, Lee Zou, Advaitha Madireddy, Zhiyuan Shen, Rémi Buisson, Tzeh Keong Foo, Haiqing Fu, Allen L. Alcivar
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
The BRCA2 tumor suppressor protects genome integrity by promoting homologous recombination-based repair of DNA breaks, stability of stalled DNA replication forks and DNA damage-induced cell cycle checkpoints. BRCA2 deficient cells display the radio-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cf269e58860fb67e6569b333099490
https://escholarship.org/uc/item/5s91p0w3
https://escholarship.org/uc/item/5s91p0w3
Protein phosphorylation and dephosphorylation is central to signal transduction in nearly every aspect of cellular function, including cardiovascular regulation and diseases. While protein kinases are often regarded as the molecular drivers in cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8149e0a7628adbe2999c0b8f1a693455
https://escholarship.org/uc/item/7wx0882d
https://escholarship.org/uc/item/7wx0882d
Autor:
Patrick Allard, Roxane Verdikt
Publikováno v:
Biology of reproduction, vol 105, iss 3
Biol Reprod
Biol Reprod
Metabolites control epigenetic mechanisms, and conversly, cell metabolism is regulated at the epigenetic level in response to changes in the cellular environment. In recent years, this metabolo-epigenetic control of gene expression has been implicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f56be4ab98303359f65d8c1576c58d
https://escholarship.org/uc/item/4pw071kj
https://escholarship.org/uc/item/4pw071kj
Publikováno v:
Seminars in Cell & Developmental Biology
The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of kinetochores, the proteinaceous structures that assemble onto chromosomes in mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f84d9523821c63fa826ec915d19b464
https://escholarship.org/uc/item/70c3m48j
https://escholarship.org/uc/item/70c3m48j
Autor:
Alec M. Avey, Keith Baar
Publikováno v:
American journal of physiology. Cell physiology, vol 321, iss 3
In organisms from flies to mammals, the initial formation of a functional tendon is completely dependent on chemical signals from muscles (myokines). However, how myokines affect the maturation, maintenance, and regeneration of tendons as a function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7529256e687b0206b5ee3a44eeffe48
https://escholarship.org/uc/item/3vx8s0rg
https://escholarship.org/uc/item/3vx8s0rg
Autor:
Prajakta Ghatpande, Risa Kashima, Hanna S. Loving, Eric S. Underbakke, Pelin Ayaz, Christopher R. Agnew, Akiko Hata, Jennifer E. Kung, Natalia Jura, Yibing Shan, David E. Shaw
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Upon ligand binding, bone morphogenetic protein (BMP) receptors form active tetrameric complexes, comprised of two type I and two type II receptors, which then transmit signals to SMAD proteins. The link between receptor tetramerization and the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bb04004f967bab4eb43abfb24c4418
https://escholarship.org/uc/item/66k326b8
https://escholarship.org/uc/item/66k326b8