Zobrazeno 101 - 110
of 689
pro vyhledávání: ''
Autor:
Vanille J. Greiner, Michael T. McManus, Shingo Kajimura, Rachana N. Pradhan, Suneil K. Koliwad, Kazuki Tajima, Zachary Brown, Rachel T. Cheang, Bruce M. Spiegelman, Takeshi Yoneshiro, Ritwik Datta, Kamran Atabai, Christopher D Yang, Qiang Wang, Hyeonwoo Kim, Diana L. Alba, Kosaku Shinoda, Caroline R. Kim, Yasuo Oguri, W. Reid Bolus, Kazuyuki Tsujino, Yong Chen, Kenji Ikeda
Publikováno v:
Cell, vol 182, iss 3
Adipose tissues dynamically remodel their cellular composition in response to external cues by stimulating beige adipocyte biogenesis; however, the developmental origin and pathways regulating this process remain insufficiently understood owing to ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91c20ee817bee8df20e47803951f57b
https://escholarship.org/uc/item/1fb2d4gg
https://escholarship.org/uc/item/1fb2d4gg
Autor:
Anne N. Harrington, Emrah Gumusgoz, Kevin Y. Yip, Anurag Sethi, Axel Visel, Elizabeth Lee, Catherine S. Novak, Mengting Gu, Richard E. Sutton, Ingrid Plajzer-Frick, Iros Barozzi, Momoe Kato, Tyler H. Garvin, Len A. Pennacchio, Quan Pham, Koon-Kiu Yan, Brandon J. Mannion, Yoko Fukuda-Yuzawa, Landon L Chan, Veena Afzal, Diane E. Dickel, Mark Gerstein, Jennifer A. Akiyama, Chengfei Yan, Joel Rozowsky
Publikováno v:
Nature methods, vol 17, iss 8
Nature methods
Nature methods
Enhancers are important non-coding elements, but they have traditionally been hard to characterize experimentally. The development of massively parallel assays allows the characterization of large numbers of enhancers for the first time. Here, we dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53516be68668786171cea79b7f4b526f
https://escholarship.org/uc/item/9q55f3n7
https://escholarship.org/uc/item/9q55f3n7
Publikováno v:
Bone
The ligands that comprise the Transforming Growth Factor β superfamily highly govern the development of the embryonic growth plate. Members of this superfamily activate canonical TGFβ and/or BMP (Bone Morphogenetic Protein) signaling pathways. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ead8831a43cf9b1b15732527c70491
https://escholarship.org/uc/item/76j2g16z
https://escholarship.org/uc/item/76j2g16z
Autor:
Yixian Cui, Muriel Mari, Smriti Parashar, Susan Ferro-Novick, Dongmei Liu, Fulvio Reggiori, Peter Novick, Shuliang Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 31
Proceedings of the National Academy of Sciences of the United States of America, 117(31), 18530-18539. NATL ACAD SCIENCES
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 117(31), 18530-18539. NATL ACAD SCIENCES
Proc Natl Acad Sci U S A
Endoplasmic reticulum (ER) macroautophagy (hereafter called ER-phagy) uses autophagy receptors to selectively degrade ER domains in response to starvation or the accumulation of aggregation-prone proteins. Autophagy receptors package the ER into auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02197d3863f584e720adcb2bfa20dfd2
https://escholarship.org/uc/item/5k59g029
https://escholarship.org/uc/item/5k59g029
Publikováno v:
Molecular biology of the cell, vol 31, iss 17
Molecular Biology of the Cell
Molecular Biology of the Cell
The positive transcription elongation factor b (P-TEFb), composed of CDK9 and cyclin T, stimulates transcriptional elongation by RNA polymerase (Pol) II and regulates cell growth and differentiation. Recently, we demonstrated that P-TEFb also control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea024d691cdc3eae1ae2fed1eda06f2
https://escholarship.org/uc/item/31c1g2m3
https://escholarship.org/uc/item/31c1g2m3
Autor:
Dmitry Velmeshev, Aparna Bhaduri, Catherine A. Rottkamp, Arturo Alvarez-Buylla, Shaohui Wang, Wei Huang, David H. Rowitch, Li Wang, Arnold R. Kriegstein
Publikováno v:
Cell, vol 182, iss 3
Cell
Cell
Human cerebral cortex size and complexity has increased greatly during evolution. While increased progenitor diversity and enhanced proliferative potential play important roles in human neurogenesis and gray matter expansion, the mechanisms of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1463cfee46c1fa63ec843ea089e5b76f
https://escholarship.org/uc/item/3xd3c8nw
https://escholarship.org/uc/item/3xd3c8nw
Autor:
Oliver Fiehn, Xin Lin, Baohua Cao, Joseph H. Graziano, Jaume Taura, William J. Rice, Kimberly M. Ray, Jonathan Liu, Yong Geng, Wayne A. Hendrickson, Zhiheng Yu, Shaoxia Chen, Matthias Quick, Hongtao Yu, Aurel Frangaj, Vesna Slavkovich, Ziao Fu, Joachim Frank, Rick Huang, Zheng Liu, Rajesh Kumar Soni, Justin P. Williams, Hao Zuo, Edward T. Eng, Qing R. Fan, Paul A. Slesinger, Robert A. Grassucci, Yongjun Kou, Oliver B. Clarke, Brian Kloss, Jinseo Park, Tong Shen, Lidia Mosyak, Jonathan A. Javitch
Publikováno v:
Nature, vol 584, iss 7820
Nature
Nature
The human GABAB receptor-a member of the class C family of G-protein-coupled receptors (GPCRs)-mediates inhibitory neurotransmission and has been implicated in epilepsy, pain and addiction1. A unique GPCR that is known to require heterodimerization f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dadef2025ff06af84fa9bb429a1c481
https://escholarship.org/uc/item/0n8972fx
https://escholarship.org/uc/item/0n8972fx
Autor:
Ruiwu Liu, Yuanpei Li, Wei Yao, Alexander Kot, Junjing Jia, Wenwu Xiao, Min Jiang, Lixian Liu, Kit S. Lam, Xueping Liu
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Activation and migration of endogenous mesenchymal stromal cells (MSCs) are critical for bone regeneration. Here, we report a combinational peptide screening strategy for rapid discovery of ligands that not only bind strongly to osteogenic progenitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de31234dabfe3bd2e6b27ed378a82103
https://escholarship.org/uc/item/01b3g7v1
https://escholarship.org/uc/item/01b3g7v1
Autor:
Scott X. Atwood, Adam L. MacLean, Christian F. Guerrero-Juarez, Stephanie C Wu, Claudia A. Benavente, Shuxiong Wang, Bao T. That, Qing Nie, Eric Tarapore, Guadalupe Gutierrez, Michael L. Drummond, Adam R. Stabell
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
How stem cells give rise to epidermis is unclear despite the crucial role the epidermis plays in barrier and appendage formation. Here we use single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human interfollicular epidermis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2151c53f7788395f28964c0ed55d831b
https://escholarship.org/uc/item/37s616c7
https://escholarship.org/uc/item/37s616c7
Autor:
Yilu Xie, Chang Rae Rho, Richard C. Prince, James V. Jester, Eric O. Potma, Jinseor Kim, Khawla Mustafa, Donald J. Brown, Sun Woong Kim
Publikováno v:
The ocular surface, vol 18, iss 3
Ocul Surf
Ocul Surf
PurposeThe purpose of this study was to access the ability of the natural PPAR agonist, eicosapentaenoic acid (EPA), to activate PPAR gamma (γ) signaling leading to meibocyte differentiation in human meibomian gland epithelial cell (hMGEC).MethodsHM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87646659e6debdc7ffb4d569282e2a08
https://escholarship.org/uc/item/3qx8062p
https://escholarship.org/uc/item/3qx8062p