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of 114
pro vyhledávání: ''
Autor:
Caiyong Ye, Anja Katrin Bielinsky, Bing Xia, Zhihua Kang, Yamei Zuo, Pan Fu, Mirit I. Aladjem, Ryan M. Baxley, Christophe E. Redon, Lee Zou, Advaitha Madireddy, Zhiyuan Shen, Rémi Buisson, Tzeh Keong Foo, Haiqing Fu, Allen L. Alcivar
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
The BRCA2 tumor suppressor protects genome integrity by promoting homologous recombination-based repair of DNA breaks, stability of stalled DNA replication forks and DNA damage-induced cell cycle checkpoints. BRCA2 deficient cells display the radio-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cf269e58860fb67e6569b333099490
https://escholarship.org/uc/item/5s91p0w3
https://escholarship.org/uc/item/5s91p0w3
Autor:
Prajakta Ghatpande, Risa Kashima, Hanna S. Loving, Eric S. Underbakke, Pelin Ayaz, Christopher R. Agnew, Akiko Hata, Jennifer E. Kung, Natalia Jura, Yibing Shan, David E. Shaw
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Upon ligand binding, bone morphogenetic protein (BMP) receptors form active tetrameric complexes, comprised of two type I and two type II receptors, which then transmit signals to SMAD proteins. The link between receptor tetramerization and the mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bb04004f967bab4eb43abfb24c4418
https://escholarship.org/uc/item/66k326b8
https://escholarship.org/uc/item/66k326b8
Autor:
Nimi M. Patel, Huan Wang, Reece M. Hoffmann, Jong Won Yang, Shujuan Gao, Karen Reue, Weijing Gu, Yong Mi Choi, Kaelin D. Fleming, John E. Burke, Michael V. Airola
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Phospholipid synthesis and fat storage as triglycerides are regulated by lipin phosphatidic acid phosphatases (PAPs), whose enzymatic PAP function requires association with cellular membranes. Using hydrogen deuterium exchange mass spectrometry, we f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b3614ae3e143f70257245699b7b27b
https://escholarship.org/uc/item/5ng3377s
https://escholarship.org/uc/item/5ng3377s
Autor:
Marlesa Godoy, Xia Yang, Jiwen Li, William G Pembroke, Lin Pan, Michael C. Condro, Harley I. Kornblum, Jessica E. Rexach, Steven A. Goldman, Daniel H. Geschwind, Linsey Stiles, Yen-Wei Chen, Angela Y. Chen, Ye Zhang, Mineli Harteni, Ina B. Wanner, Alvaro G. Alvarado
Publikováno v:
Nature communications, vol 12, iss 1
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse models and the similarities and differences between human and mouse astrocytes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fdf29ea59d3d4b1e05472ac4de6a42
https://escholarship.org/uc/item/2290r3jj
https://escholarship.org/uc/item/2290r3jj
Autor:
George E. Ghanim, Kathleen Collins, Rhiju Das, Adam J. Fountain, Ramya Rangan, Thi Hoang Duong Nguyen, Anne-Marie M. van Roon
Publikováno v:
Nature, vol 593, iss 7859
Nature
Nature
Telomerase adds telomeric repeats at chromosome ends to compensate for the telomere loss that is caused by incomplete genome end replication1. In humans, telomerase is upregulated during embryogenesis and in cancers, and mutations that compromise the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87713b8704f264df1202f35546bba4ab
https://escholarship.org/uc/item/5v97b0vv
https://escholarship.org/uc/item/5v97b0vv
Autor:
Lin Fu Zhu, Vrajesh Pandya, Raven Kirschenman, Namita Tripathi, Namrata Patel, Nika N. Danial, John Maringa Githaka, David A. Kramer, Rachel Montpetit, Nahum Sonenberg, D. Alan Underhill, Ing Swie Goping, Richard P. Fahlman
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Elucidation of non-canonical protein functions can identify novel tissue homeostasis pathways. Herein, we describe a role for the Bcl-2 family member BAD in postnatal mammary gland morphogenesis. In Bad3SA knock-in mice, where BAD cannot undergo phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bd5fcca741a8bd55d9fd92b80db1b1
https://escholarship.org/uc/item/5mg5h2b9
https://escholarship.org/uc/item/5mg5h2b9
Autor:
Guillaume Luxardi, Denis Torre, Evan Austin, Emanual Michael Maverakis, Eugene Koo, Roslyn Rivkah Isseroff, Alina I. Marusina, Alexander A. Merleev, Avi Ma'ayan, Jared Jagdeo, Andrew Mamalis
Publikováno v:
Scientific reports, vol 11, iss 1
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Fibrosis occurs when collagen deposition and fibroblast proliferation replace healthy tissue. Red light (RL) may improve skin fibrosis via photobiomodulation, the process by which photosensitive chromophores in cells absorb visible or near-infrared l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c854db790afecb1e5b6ce38061091342
https://escholarship.org/uc/item/08m9d4fz
https://escholarship.org/uc/item/08m9d4fz
Autor:
Steve Horvath, Simon T. Schafer, Dylan A. Reid, Ake T. Lu, Fred H. Gage, Christopher K. Glass, Patrick J. Reed, Grace Chou, Claire A. McClain, Jeffrey R. Jones, Jesse R. Dixon, Sahaana Chandran, Addison J. Lana, Anthony S. Ricciardulli, Enoch C. Tsui, Ioana I. Nitulescu, Tzu-Wen Wang, Jean H. Ooi, Shong Lau, Johannes C. M. Schlachetzki, Nasun Hah, Sara B. Linker
Publikováno v:
Science (New York, N.Y.), vol 372, iss 6537
Science
Science
DNA repair within neurons Humans have only a limited capacity to generate new neurons. These cells thus need to repair errors in the genome. To better understand this process, Reid et al. developed Repair-seq, a method to locate DNA repair within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d60dd82faff91dff991ec21a36ff828
https://escholarship.org/uc/item/5px9q677
https://escholarship.org/uc/item/5px9q677
Autor:
John M. Asara, Jun Xu, Gina Lee, Chiwei Xu, Ah-Ram Kim, Cathleen Li, Hong-Wen Tang, John Blenis, Yanhui Hu, Richard Binari, Zhangfei Shen, Sungyun Cho, Norbert Perrimon, Jui-Hsia Weng, Wen Xing Lee, Min En Cheng, Lei Gu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 10
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Significance N6-methyladenosine (m 6 A) is the most prevalent modification in eukaryotic messenger RNA (mRNA) and affects RNA metabolism including splicing, stability, and translation. The m 6 A methyltransferase complex (MTC) is responsible for gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402a151653bef9807432db241cfa6551
https://escholarship.org/uc/item/7j09097s
https://escholarship.org/uc/item/7j09097s
Autor:
Susan Carpenter, Daisy Kuang, Justin Iwuagwu, Kasthuribai Viswanathan, Ran Song, Sergio Covarrubias, Sol Katzman, Aaron Shulkin, Edward K. Wakeland, Christopher Vollmers, Apple Cortez Vollmers
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 7
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Inflammation has largely been studied in the context of protein-coding genes. Recent studies have uncovered lncRNAs as important regulators of immunity. The functional characterization of these genes remains an active area of research. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6234e1999ecf122c7bdde7a041204fc9
https://escholarship.org/uc/item/9pv61452
https://escholarship.org/uc/item/9pv61452