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Publikováno v:
J Mol Cell Cardiol
Since the initial isolation of human embryonic stem cells and subsequent discovery of reprogramming methods for somatic cells, thousands of protocols have been developed to create each of the hundreds of cell types found in-vivo with significant focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81c15000810c1ee24eded95cdbe7db1
https://escholarship.org/uc/item/6sp868hn
https://escholarship.org/uc/item/6sp868hn
Publikováno v:
Biochem Pharmacol
The Hedgehog (Hh) family of lipid-modified signaling proteins directs embryonic tissue patterning and postembryonic tissue homeostasis, and dysregulated Hh signaling drives familial and sporadic cancers. Hh ligands bind to and inhibit the tumor suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e41d47683cea1a2be693eb6730efed
https://escholarship.org/uc/item/1jh7c8jg
https://escholarship.org/uc/item/1jh7c8jg
Publikováno v:
RNA (New York, N.Y.), vol 27, iss 12
RNA
RNA
DDX3 is a DEAD-box RNA helicase that regulates translation and is encoded by the X- and Y-linked paralogsDDX3XandDDX3Y. While DDX3X is ubiquitously expressed in human tissues and essential for viability, DDX3Y is male-specific and shows lower and mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dec65a28f7797b3069dc3f648130932
https://escholarship.org/uc/item/4zr6x7w0
https://escholarship.org/uc/item/4zr6x7w0
Autor:
Michael J. Emanuele, Nicholas G. Brown, Jeremy E. Purvis, Xianxi Wang, Seth M. Rubin, Peter Ngoi, Wayne Stallaert, Taylor P. Enrico, Elizaveta T Wick
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Cell cycle gene expression programs fuel proliferation and are universally dysregulated in cancer. The retinoblastoma (RB)-family of proteins, RB1, RBL1/p107, and RBL2/p130, coordinately represses cell cycle gene expression, inhibiting proliferation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720f33fb52706b3e083f65286fba3426
https://escholarship.org/uc/item/8599v3g3
https://escholarship.org/uc/item/8599v3g3
Autor:
Samhita Jain, Maximilian Haeussler, Tao Li, Keith B. Hengen, Tomasz J. Nowakowski, David Shin, Richard R. Ransohoff, Kelsey M. Hennick, Shalin B. Mehta, Christopher S. McGinnis, Matthew L. Speir, Zev J. Gartner, Matthew G. Keefe, Chang N. Kim, Sarah S. Soliman, Bryant B. Chhun, Dario Tejera, Xianhua Piao, Galina Popova
Publikováno v:
Cell stem cell, vol 28, iss 12
Microglia are resident macrophages in the brain that emerge in early development and respond to the local environment by altering their molecular and phenotypic states. Fundamental questions about microglia diversity and function during development r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07501263c562907d27e7385a92f3f463
https://escholarship.org/uc/item/1xh229wx
https://escholarship.org/uc/item/1xh229wx
Autor:
Ane M. Salvador, Mark Chaffin, Louise C. Laurent, Srimeenakshi Srinivasan, Aushee Khamesra, Ionita Ghiran, John Tigges, Robert R. Kitchen, Nedyalka Valkov, Patrick T. Ellinor, Saumya Das, Shulin Lu, Ashish Yeri, Nathan R. Tucker, Olivia Ziegler, Avash Das, Priyanka Gokulnath, Vasilis Toxavidis, Stefan Momma, Rodosthenis S. Rodosthenous, Ivan Kur, Getulio Pereira De Oliveira Junior, Chunyang Xiao, Guoping Li
Publikováno v:
Life science alliance, vol 4, iss 12
Life Science Alliance
Life Science Alliance
In a unique model of fluorescent based mapping of EV recipient cells, RBC-EVs were found to signal to cardiac cells and regulate gene expression in a model of ischemic heart failure.
Extracellular vesicles (EVs) mediate intercellular signaling b
Extracellular vesicles (EVs) mediate intercellular signaling b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc8c16e5e09781d756db5e9f67f449e
https://escholarship.org/uc/item/4nd033sn
https://escholarship.org/uc/item/4nd033sn
Publikováno v:
The Journal of biological chemistry, vol 297, iss 5
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Unique among metazoan repressive histone methyltransferases, G9a and GLP, which chiefly target histone 3 lysine 9 (H3K9), require dimerization for productive H3K9 mono (me1)- and dimethylation (me2) invivo. Intriguingly, even though each enzyme can i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000f989643cd92bff494c1b9a5f79ee5
https://escholarship.org/uc/item/0nm6s474
https://escholarship.org/uc/item/0nm6s474
Publikováno v:
Nature reviews. Immunology, vol 21, iss 11
Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and malignant cells and can provide long-term protective immunity. In the response to infection, CD8+ T cell metabolism is coupled to transcriptional, translational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de632eac1b1397241c357281c4512aa
https://escholarship.org/uc/item/1n49006c
https://escholarship.org/uc/item/1n49006c
Protein phosphorylation and dephosphorylation is central to signal transduction in nearly every aspect of cellular function, including cardiovascular regulation and diseases. While protein kinases are often regarded as the molecular drivers in cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8149e0a7628adbe2999c0b8f1a693455
https://escholarship.org/uc/item/7wx0882d
https://escholarship.org/uc/item/7wx0882d
Autor:
Patrick Allard, Roxane Verdikt
Publikováno v:
Biology of reproduction, vol 105, iss 3
Biol Reprod
Biol Reprod
Metabolites control epigenetic mechanisms, and conversly, cell metabolism is regulated at the epigenetic level in response to changes in the cellular environment. In recent years, this metabolo-epigenetic control of gene expression has been implicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f56be4ab98303359f65d8c1576c58d
https://escholarship.org/uc/item/4pw071kj
https://escholarship.org/uc/item/4pw071kj