Zobrazeno 1 - 10
of 12
pro vyhledávání: ''
Autor:
Sean T. Glenn, Antonios Papanicolau-Sengos, Jeffrey M. Conroy, Blake Burgher, Keisuke Shirai, Carl Morrison, Rajan T. Gupta, Jason Zhu, Konstantin H. Dragnev, Pooja Ghatalia, Razelle Kurzrock, Mary Nesline, Saby George, Vincent Giamo, Wiam Bshara, Tian Zhang, Felicia L. Lenzo, Katherine G. Madden, Matthew Labriola, Bo Xu, Michelle S Park, Matthew Zibelman, Jonathan Andreas, Rajbir Singh, Robert Edwards, Daniel J. George, Shannon J. McCall, Robin Jacob, Yirong Wang, Laura J. Tafe, Farshid Dayyani, Sarabjot Pabla
Publikováno v:
Oncoimmunology, vol 9, iss 1
OncoImmunology, Vol 9, Iss 1 (2020)
Oncoimmunology
article-version (VoR) Version of Record
OncoImmunology, Vol 9, Iss 1 (2020)
Oncoimmunology
article-version (VoR) Version of Record
Background Biomarkers predicting immunotherapy response in metastatic renal cell cancer (mRCC) are lacking. PD-L1 immunohistochemistry is a complementary diagnostic for immune checkpoint inhibitors (ICIs) in mRCC, but has shown minimal clinical utili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff593a12aca94a5d478080ce2c81122
https://escholarship.org/uc/item/99z646zc
https://escholarship.org/uc/item/99z646zc
Autor:
Christine H. Chung, Melissa Lynne Johnson, F. Toffalorio, Michael J. Pishvaian, Bo Huang, Ezra E.W. Cohen, Jared Weiss, Aron Thall, Craig Davis, Ying Chen, Dale R. Shepard, Ding Wang, Steven Francis Powell
Publikováno v:
Journal for immunotherapy of cancer, vol 7, iss 1
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-11 (2019)
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-11 (2019)
Journal for Immunotherapy of Cancer
Background Expressed on activated T and natural killer cells, 4-1BB/CD137 is a costimulatory receptor that signals a series of events resulting in cytokine secretion and enhanced effector function. Targeting 4-1BB/CD137 with agonist antibodies has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f885db5e7e20950640891dfe26739b
https://escholarship.org/uc/item/5bf0m4wn
https://escholarship.org/uc/item/5bf0m4wn
Autor:
Andrew Craig MacKinnon, Kunle Odunsi, Lynn Dressler, Vincent Giamo, Mark Gardner, Matthew Labriola, Mark R Steciuk, Laura J. Tafe, Ben George, Jacob Hagen, Hongbin Chen, Jeffrey M. Conroy, Isabel Araujo-Fernandez, Konstantin H. Dragnev, Oliver A Binns, Wiam Bshara, Jeffrey M. Clarke, Tian Zhang, Edwin Yau, Mary Nesline, Deepa Kasuganti, Felicia L. Lenzo, Neel Shah, Matthew Zibelman, Sean T. Glenn, Blake Burgher, Marc S. Ernstoff, Jonathan Andreas, Rajbir Singh, Katherine G. Madden, Wang Yirong, Grace K. Dy, Pooja Ghatalia, Jonathan Thompson, Robin Jacob, Keisuke Shirai, Arun K Singavi, Daniele Marin, Antonios Papanicolau-Sengos, Sarabjot Pabla, Jason Zhu, Amy P. Early, Razelle Kurzrock, Carl Morrison, Shannon J. McCall, Lorenzo Galluzzi
Publikováno v:
Journal for immunotherapy of cancer, vol 7, iss 1
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)
Background Resistance to immune checkpoint inhibitors (ICIs) has been linked to local immunosuppression independent of major ICI targets (e.g., PD-1). Clinical experience with response prediction based on PD-L1 expression suggests that other factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b943366b5609140ecd0641fc7b25e61
https://escholarship.org/uc/item/5gr3z6s1
https://escholarship.org/uc/item/5gr3z6s1
Autor:
Elena Masetto, Paola Del Bianco, Susanna Mandruzzato, Jean-Pierre Benoit, Alessandro Della Puppa, Samantha Solito, Marta D’Andolfi, Aaron Diaz, Hideho Okada, Sara Magri, Giovanna Lollo, Laura Pinton, Marina Vettore
Publikováno v:
Journal for immunotherapy of cancer, vol 7, iss 1
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-14 (2019)
Journal for Immunotherapy of Cancer, BMJ Publishing Group 2019, 7 (1)
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-14 (2019)
Journal for Immunotherapy of Cancer, BMJ Publishing Group 2019, 7 (1)
Background Systemic and local immune suppression plays a significant role in glioma progression. Glioma microenvironment contains both brain-resident microglial cells (MG) and bone marrow-derived macrophages (BMDM), but the study of their functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3043ccfba1158257cc52ccc7a405cc51
https://escholarship.org/uc/item/83g2q664
https://escholarship.org/uc/item/83g2q664
Autor:
Jennifer Clarke, Jennie Taylor, Mili Parikh, Mitchel S. Berger, Michael D. Prados, Susan M. Chang, Joanna J. Phillips, Nancy Ann Oberheim-Bush, C. David James, Nicholas Butowski, Annette M. Molinaro
Publikováno v:
Journal of neuro-oncology, vol 140, iss 2
IntroductionAlterations in the CDK4/6-RB signaling pathway are common causes of cell cycle dysregulation in many cancers, including glioblastoma. Palbociclib is an oral inhibitor of CDK4/6, which leads to phosphorylation of RB1 and cell-cycle arrest.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ea4523933282a4dea778d64cd2c6e1
https://escholarship.org/uc/item/8xs6811k
https://escholarship.org/uc/item/8xs6811k
Autor:
Panayiotis E. Pelargos, Seyed A. Hojat, Thien Nguyen, John P. Sheppard, Timothy F. Cloughesy, Lawrance K. Chung, Carlito Lagman, Linda M. Liau, Albert Lai, Robert M. Prins, Yu-Ling Chang, Joanna V. Demos, Isaac Yang, Ann M. Chan, William H. Yong, Lynn K. Gordon, Madhuri Wadehra, Leia Nghiemphu
Publikováno v:
Brain tumor pathology, vol 35, iss 1
Epithelial membrane protein-2 (EMP2) expression is noted in many human cancers. We evaluated EMP2 as a biomarker in gliomas. A large tissue microarray of lower grade glioma (WHO grades II-III, n=19 patients) and glioblastoma (GBM) (WHO grade IV, n=50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681a6e5e3eb299cb818fd6295ce37d03
https://escholarship.org/uc/item/15r0h202
https://escholarship.org/uc/item/15r0h202
Autor:
Lauren E. Howard, Skyla T. Carney, Stephen J. Freedland, Jiaoti Huang, Delores J. Grant, Adriana C. Vidal, Amanda De Hoedt, Emily Wiggins, Clara E. Magyar, Zinan Chen, Jill Squires
Publikováno v:
BMC cancer, vol 17, iss 1
BMC Cancer
BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017)
BMC Cancer
BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017)
BackgroundUridine 5'-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal tissue. The expression of the UGT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f8f997a5ed8def9316395dba0bcd44
https://escholarship.org/uc/item/3pf6t1sk
https://escholarship.org/uc/item/3pf6t1sk
Autor:
Wei Wang, Wenqian Zhang, Zhidong Xu, Ping-Chih Hsu, Yuyuan Dai, David M. Jablons, Alfred Au, Liang You, Shu-Juan Jiang, Hui Wang, Geraldine Chan, Yucheng Wang, Yi-Lin Yang
Publikováno v:
International journal of oncology, vol 51, iss 1
International Journal of Oncology
International Journal of Oncology
Malignant pleural mesothelioma (MPM) is an aggressive cancer for which more effective treatments are needed. In this study, strong to moderate staining of MET and ERK5 was detected in 67.1 and 48% of the analyzed 73human mesothelioma tumors, and sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e638767927b8e14d13f16acd4e327a2
https://escholarship.org/uc/item/4rn596mk
https://escholarship.org/uc/item/4rn596mk
Autor:
Todd M. Morgan, Simpa S. Salami, Scott A. Tomlins, Daniel H. Hovelson, Jarred V. Bratley, Lakshmi P. Kunju, Kelly R. Vandenberg, Jiaoti Huang, Andi K. Cani, Jeffery S. Montgomery, Chia Jen Liu, Shyam Natarajan, Ganesh S. Palapattu, Leonard S. Marks, Lorena Lazo de la Vega
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 23, iss 4
Purpose: To determine whether MRI/ultrasound (MRI/US) fusion biopsy facilitates longitudinal resampling of the same clonal focus of prostate cancer and to determine whether high-grade cancers can evolve from low-grade clones. Experimental Design: All
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb16e4d7364afd91d3ac9661cf7726a
https://escholarship.org/uc/item/8xt96984
https://escholarship.org/uc/item/8xt96984
Autor:
Elliot Levy, Mark Raffeld, Melissa Walker, Brad Wood, Oxana V. Makarova-Rusher, William D. Figg, Osama E. Rahma, Seth M. Steinberg, Shahed Abdullah, Tim F. Greten, Alexey S. Revenko, Austin G. Duffy, A.R. MacLeod, Cody J. Peer, Victoria L. Anderson, Su Jae Lee, Susanna Varkey Ulahannan, Jane B. Trepel, Nadine Abi-Jaoudeh, Yasushi Tomita, Suzanne Fioravanti
Publikováno v:
International journal of cancer, vol 139, iss 7
The eukaryotic translation initiation factor 4E (eIF4E) is a potent oncogene that is found to be dysregulated in 30% of human cancer, including colorectal carcinogenesis (CRC). ISIS 183750 is a second-generation antisense oligonucleotide (ASO) design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64dc8f62cc33a7010ef29a9dd86be5fc
https://escholarship.org/uc/item/58v0n649
https://escholarship.org/uc/item/58v0n649