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Autor:
Oscar Silva, J. King, May Paing, Julia Philipp, Dinesh S. Rao, Tasha L. Lin, Tiffany M. Tran, Jaspal Bassi, Sol Katzman, Jeremy R. Sanford, Amit Kumar Jaiswal, Jolene M. Draper, Neha Nibber, Jayanth Kumar Palanichamy
Publikováno v:
Leukemia, vol 36, iss 1
Leukemia
Leukemia
Despite recent advances in therapeutic approaches, patients with MLL-rearranged leukemia still have poor outcomes. Here, we find that the RNA-binding protein IGF2BP3, which is overexpressed in MLL-translocated leukemia, strongly amplifies MLL-Af4-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5597ab10bcdee8f0c9f1537a25fd07
https://escholarship.org/uc/item/5wr144fv
https://escholarship.org/uc/item/5wr144fv
Autor:
Soo-Jin Cho, Andrew E. Horvai, Rosanna Wustrack, Diamond Luong, Melissa Zimel, Ross A. Okimoto, Evans Shao, Lawrence Fong, Joey Sheridan, Serena S. Kwek
Publikováno v:
Cancer immunology, immunotherapy : CII, vol 70, iss 10
Cancer Immunology, Immunotherapy
Cancer Immunology, Immunotherapy
Background Soft-tissue sarcomas (STS) are a rare group of mesenchymal malignancies that account for approximately 1% of adult human cancer. Undifferentiated pleomorphic sarcoma (UPS) is one of the most common subtypes of adult STS. Clinical stratific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea84654b35d9251803e3a03cb3d73ce0
https://escholarship.org/uc/item/46d8d122
https://escholarship.org/uc/item/46d8d122
Autor:
Yasuhiro Funahashi, Hiroki Ikezawa, Lucjan Wyrwicz, Richard S. Finn, Masatoshi Kudo, Shukui Qin, Min Ren, Thomas R. Jeffry Evans, Ari David Baron, Roger K.C. Ngan, Yukinori Minoshima, Fabio Piscaglia, Ann-Lii Cheng, Masafumi Ikeda, Arndt Vogel, Corina E. Dutcus, Jean-Frédéric Blanc, R. Dairiki, Toshiyuki Tamai, Kwang Hyub Han, Michio Kanekiyo
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 27, iss 17
Purpose: In REFLECT, lenvatinib demonstrated an effect on overall survival (OS) by confirmation of noninferiority to sorafenib in unresectable hepatocellular carcinoma. This analysis assessed correlations between serum or tissue biomarkers and effica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e245abccc423a21d39f4cc905212001
https://escholarship.org/uc/item/9fv0c960
https://escholarship.org/uc/item/9fv0c960
Publikováno v:
PLoS genetics, vol 17, iss 9
PLoS Genetics, Vol 17, Iss 9, p e1009733 (2021)
PLoS Genetics
PLoS Genetics, Vol 17, Iss 9, p e1009733 (2021)
PLoS Genetics
Increasingly large Genome-Wide Association Studies (GWAS) have yielded numerous variants associated with many complex traits, motivating the development of “fine mapping” methods to identify which of the associated variants are causal. Additional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167463b3e46abacc7e9975d4b9a4050a
https://escholarship.org/uc/item/0zm7095b
https://escholarship.org/uc/item/0zm7095b
Autor:
Jenna M. Giafaglione, Jack Freeland, Preston D. Crowell, Andrew S. Goldstein, Paul C. Boutros
Publikováno v:
Cancer Lett
Many organs experience a loss of tissue mass and a decline in regenerative capacity during aging. In contrast, the prostate continues to grow in volume. In fact, age is the most important risk factor for prostate cancer. However, the age-related fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ed3cd497d8064cc477abb1949a333c
https://escholarship.org/uc/item/2g22r1tt
https://escholarship.org/uc/item/2g22r1tt
Autor:
Amrita Ahluwalia, Andrzej S. Tarnawski
Publikováno v:
Cells, vol 10, iss 8
Cells
Cells, Vol 10, Iss 1964, p 1964 (2021)
Cells
Cells, Vol 10, Iss 1964, p 1964 (2021)
In this article we review the cellular and molecular mechanisms of gastric ulcer healing. A gastric ulcer (GU) is a deep defect in the gastric wall penetrating through the entire mucosa and the muscularis mucosae. GU healing is a regeneration process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caafdd02fcca415b7fdfd4ced0891cd9
https://escholarship.org/uc/item/4117n8wk
https://escholarship.org/uc/item/4117n8wk
Autor:
Arnab Chattopadhyay, Alan M. Fogelman, Samuel C. Delk, Joan Carles Escolà-Gil, Srinivasa T. Reddy
Publikováno v:
Semin Cancer Biol
SEMINARS IN CANCER BIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
SEMINARS IN CANCER BIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Peptides have many advantages over traditional therapeutics, including small molecules and other biologics, because of their low toxicity and immunogenicity, while still exhibiting efficacy. This review discusses the benefits and mechanism of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44283b4a8486af082b08eac7565b1044
https://escholarship.org/uc/item/63q1j8z1
https://escholarship.org/uc/item/63q1j8z1
Autor:
Meghan Sri Karuturi, Tara Sanft, Denise A. Yardley, Angela DeMichele, Sibel Blau, Sara A. Hurvitz, Hope S. Rugo, Amy S. Clark, Amelia Zelnak, Aditya Bardia, Das Purkayastha, Cynthia X. Ma, Lowell L. Hart, Stacy L. Moulder
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 27, iss 15
Purpose: Standard-of-care treatment for metastatic hormone receptor–positive (HR+), HER2-negative (HER2−) breast cancer includes endocrine therapy (ET) combined with a cyclin-dependent kinase 4/6 inhibitor (CDK4/6i). Optimal treatment after progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d10c70a51cc377dfe2b31a20be89ec
https://escholarship.org/uc/item/0mj128b0
https://escholarship.org/uc/item/0mj128b0
Autor:
John R. Teijaro, Allison M. Campbell, Arta M. Monjazeb, Ariel E. Marciscano, Susan M. Kaech, Heather M. McGee
Publikováno v:
Journal of the National Cancer Institute, vol 113, iss 8
J Natl Cancer Inst
J Natl Cancer Inst
Improved understanding of host antiviral defense and antitumor immunity have elucidated molecular pathways important to both processes. During viral infection, RNA or DNA in the host cell serves as a danger signal that initiates the antiviral respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ebf89b68fdb7f288b8e194eade7649
https://escholarship.org/uc/item/3w41f8tm
https://escholarship.org/uc/item/3w41f8tm
Autor:
Eustratios Bananis, Angela DeMichele, Xin Huang, Hiroji Iwata, Kathy Puyana Theall, Sybille Loibl, Adam Brufsky, Massimo Cristofanilli, Lynn McRoy, Hope S. Rugo, Nadia Harbeck, Nicholas C. Turner, Yoon Hee Park
Publikováno v:
The oncologist, vol 26, iss 8
The Oncologist
The Oncologist
Background This analysis investigated whether baseline characteristics affect the survival benefit derived from palbociclib‐fulvestrant and the optimal timing of cyclin‐dependent kinase 4/6 inhibitor therapy for advanced breast cancer (ABC) in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfdd6b7cc76eed57315256c47e25a104
https://escholarship.org/uc/item/9sw870xk
https://escholarship.org/uc/item/9sw870xk