Zobrazeno 1 - 10
of 58
pro vyhledávání: '"11"'
Autor:
Ivan S. Yuhanna, William L. Holland, Kenneth Hoyt, Jun Peng, Robert F. Mattrey, Mohamed M. Ahmed, Jennifer J. Kohler, Debabrata Ghosh, Marina Botto, Philip W. Shaul, Wanpen Vongpatanasin, Chieko Mineo, Keiji Tanigaki, Anastasia Sacharidou, Shashank R. Sirsi, Parastoo Azadi, Qiushi Chen, Alexander J. Szalai, Ken L. Chambliss, Ildiko Lingvay
Publikováno v:
The Journal of clinical investigation, vol 128, iss 1
Type 2 diabetes mellitus (T2DM) is a common complication of obesity. Here, we have shown that activation of the IgG receptor FcγRIIB in endothelium by hyposialylated IgG plays an important role in obesity-induced insulin resistance. Despite becoming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f20ef49466bd441fa4d75d5b29deeb57
https://escholarship.org/uc/item/9330506p
https://escholarship.org/uc/item/9330506p
Autor:
Shaoguang Li, Azin Sayad, Joel C. Rosenbaum, Wayne W. Chan, Carl Virtanen, Benjamin G. Neel, Golam Mohi, Richard A. Van Etten, Shengqing Gu, Zhibin Lu
Publikováno v:
Gu, Shengqing; Chan, Wayne W; Mohi, Golam; Rosenbaum, Joel; Sayad, Azin; Lu, Zhibin; et al.(2016). Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1. BLOOD, 127(14), 1803-1813. doi: 10.1182/blood-2015-06-653006. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/71n4b4r6
Gu, Shengqing; Chan, Wayne W; Mohi, Golam; Rosenbaum, Joel; Sayad, Azin; Lu, Zhibin; et al.(2016). Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.. Blood, 127(14), 1803-1813. doi: 10.1182/blood-2015-06-653006. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/51r7s8d2
Gu, Shengqing; Chan, Wayne W; Mohi, Golam; Rosenbaum, Joel; Sayad, Azin; Lu, Zhibin; et al.(2016). Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.. Blood, 127(14), 1803-1813. doi: 10.1182/blood-2015-06-653006. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/51r7s8d2
Tyrosine kinase inhibitors (TKIs) directed against BCR-ABL1, the product of the Philadelphia (Ph) chromosome, have revolutionized treatment of patients with chronic myeloid leukemia (CML). However, acquired resistance to TKIs is a significant clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2daec19826bb2e5ea80ee407d90a4382
http://www.escholarship.org/uc/item/71n4b4r6
http://www.escholarship.org/uc/item/71n4b4r6
Autor:
Guillaume Luxardi, Denis Torre, Evan Austin, Emanual Michael Maverakis, Eugene Koo, Roslyn Rivkah Isseroff, Alina I. Marusina, Alexander A. Merleev, Avi Ma'ayan, Jared Jagdeo, Andrew Mamalis
Publikováno v:
Scientific reports, vol 11, iss 1
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Fibrosis occurs when collagen deposition and fibroblast proliferation replace healthy tissue. Red light (RL) may improve skin fibrosis via photobiomodulation, the process by which photosensitive chromophores in cells absorb visible or near-infrared l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c854db790afecb1e5b6ce38061091342
https://escholarship.org/uc/item/08m9d4fz
https://escholarship.org/uc/item/08m9d4fz
Autor:
Nikos Kyritsis, Jacqueline C. Bresnahan, Karen-Amanda Irvine, John C. Gensel, Rajiv R. Ratan, Jessica L. Nielson, Michael C. Oldham, J.R. Huie, Mark R. Segal, Michael S. Beattie, Jonathan Z. Pan, Amity Lin, Adam R. Ferguson, Patrick G. Schupp
Publikováno v:
Scientific reports, vol 11, iss 1
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
SUMMARYTraumatic spinal cord injury (SCI) produces a complex syndrome that is expressed across multiple endpoints ranging from molecular and cellular changes to functional behavioral deficits. Effective therapeutic strategies for CNS injury are there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d88e3e42b981826baf038dde7aa4fd2
https://escholarship.org/uc/item/75d653j4
https://escholarship.org/uc/item/75d653j4
Autor:
Philip Doble, Nerida Cole, Stanley F. Nelson, Rachelle H. Crosbie, Jonathan Wanagat, Elizabeth M. Gibbs, M. Carrie Miceli, Florian Barthélémy, Mika T. Westerhausen, Thomas E. Lockwood, David P. Bishop
Publikováno v:
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Emerging and promising therapeutic interventions for Duchenne muscular dystrophy (DMD) are confounded by the challenges of quantifying dystrophin. Current approaches have poor precision, require large amounts of tissue, and are difficult to standardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46ab79deae922266e4ba36a083c2365
https://escholarship.org/uc/item/28f1f85p
https://escholarship.org/uc/item/28f1f85p
Autor:
Nikki K. Lytle, Hyog Young Kwon, Michael Hamilton, Jeevisha Bajaj, Ferdous Anower-E-Khuda, Tannishtha Reya, Mark H. Ginsberg, Jeffrey D. Esko, Bryan Zimdahl, Armin Ahmadi, Kyle R. Spinler, Joi Weeks, Jan Karlseder, Claire S. Koechlein, Marcie Kritzik, Hao Sun, Pyong Woo Park, Allen Blevins, Takahiro Ito
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Intratumoral heterogeneity is a common feature of many myeloid leukemias and a significant reason for treatment failure and relapse. Thus, identifying the cells responsible for residual disease and leukemia re-growth is critical to better understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d060c5584d0922de3b8568c04b179d6
https://escholarship.org/uc/item/7vk3p3vd
https://escholarship.org/uc/item/7vk3p3vd
Autor:
Xiaorong Yang, Yajun Yang, Zhenhua Zhang, Rui Liu, Athurva Gore, Ziyu Yuan, Yuan Gao, Zhen Xie, Kun Zhang, Zhe Li, Chen Suo, Xiaojie Li, Min Fan, Yanfeng Jiang, He Qiye, Li Jin, Xiaofeng Wang, Xingdong Chen, Hongyu Niu, Juan Zhang, Tiejun Zhang, Weimin Ye, Catie McConnell, Ming Lu, Jun Min, Justin Dang, Shun-Zhang Yu, Jeffrey A. Gole, Jiucun Wang, Lei Cheng, Han Shi, Xiang Zhang
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fa5e72715a251ee130ead4dc62f8f5
https://escholarship.org/uc/item/35f8h6p9
https://escholarship.org/uc/item/35f8h6p9
Autor:
Yulong He, Seung Jun Lee, Cholsoon Jang, Stefan Offermanns, Kibaek Choe, Hosung Bae, Gou Young Koh, Hyuek Jong Lee, Choong-kun Lee, Ki Yong Hong
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Proper storage of excessive dietary fat into subcutaneous adipose tissue (SAT) prevents ectopic lipid deposition-induced insulin resistance, yet the underlying mechanism remains unclear. Here, we identify angiopoietin-2 (Angpt2)–integrin α5β1 sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de5f5f5f36f103441e0a1d47b9cb0fb
https://escholarship.org/uc/item/310043px
https://escholarship.org/uc/item/310043px
Autor:
Christine E. Brown, Uyen Tran, Eugenia Zah, Eunwoo Nam, Brenda Y. Ji, Xiuli Wang, Vinya Bhuvan, Yvonne Y. Chen, Stanley B. Gosliner
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Chimeric antigen receptor (CAR)-T cell therapy has shown remarkable clinical efficacy against B-cell malignancies, yet marked vulnerability to antigen escape and tumor relapse exists. Here we report the rational design and optimization of bispecific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c151396e29e87f0556585ecc2e7b36
https://escholarship.org/uc/item/82q2j32v
https://escholarship.org/uc/item/82q2j32v
Autor:
Jonas C. Schupp, Lisa A Hazelwood, Dean Sheppard, Ivan O. Rosas, John R. Wilson-Kanamori, J. Wetter, Naftali Kaminski, Michael A. Matthay, Neil C. Henderson, Tatsuya Tsukui, Sergio Poli, Taylor Adams, Kai-Hui Sun, Paul J. Wolters
Publikováno v:
Nature communications, vol 11, iss 1
Tsukui, T, Sun, K-H, Wetter, J B, Wilson-Kanamori, J R, Hazelwood, L A, Henderson, N C, Adams, T S, Schupp, J C, Poli, S D, Rosas, I O, Kaminski, N, Matthay, M A, Wolters, P J & Sheppard, D 2020, ' Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis ', Nature Communications, vol. 11, no. 1, pp. 1920 . https://doi.org/10.1038/s41467-020-15647-5
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Tsukui, T, Sun, K-H, Wetter, J B, Wilson-Kanamori, J R, Hazelwood, L A, Henderson, N C, Adams, T S, Schupp, J C, Poli, S D, Rosas, I O, Kaminski, N, Matthay, M A, Wolters, P J & Sheppard, D 2020, ' Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis ', Nature Communications, vol. 11, no. 1, pp. 1920 . https://doi.org/10.1038/s41467-020-15647-5
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Collagen-producing cells maintain the complex architecture of the lung and drive pathologic scarring in pulmonary fibrosis. Here we perform single-cell RNA-sequencing to identify all collagen-producing cells in normal and fibrotic lungs. We character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df08bc653570e2bcae6b20b7e089763c
https://escholarship.org/uc/item/5n17z80z
https://escholarship.org/uc/item/5n17z80z