Zobrazeno 1 - 10
of 294
pro vyhledávání: ''
Publikováno v:
Biochem Pharmacol
The Hedgehog (Hh) family of lipid-modified signaling proteins directs embryonic tissue patterning and postembryonic tissue homeostasis, and dysregulated Hh signaling drives familial and sporadic cancers. Hh ligands bind to and inhibit the tumor suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e41d47683cea1a2be693eb6730efed
https://escholarship.org/uc/item/1jh7c8jg
https://escholarship.org/uc/item/1jh7c8jg
Publikováno v:
Nature reviews. Immunology, vol 21, iss 11
Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and malignant cells and can provide long-term protective immunity. In the response to infection, CD8+ T cell metabolism is coupled to transcriptional, translational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de632eac1b1397241c357281c4512aa
https://escholarship.org/uc/item/1n49006c
https://escholarship.org/uc/item/1n49006c
Protein phosphorylation and dephosphorylation is central to signal transduction in nearly every aspect of cellular function, including cardiovascular regulation and diseases. While protein kinases are often regarded as the molecular drivers in cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8149e0a7628adbe2999c0b8f1a693455
https://escholarship.org/uc/item/7wx0882d
https://escholarship.org/uc/item/7wx0882d
Publikováno v:
Seminars in Cell & Developmental Biology
The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of kinetochores, the proteinaceous structures that assemble onto chromosomes in mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f84d9523821c63fa826ec915d19b464
https://escholarship.org/uc/item/70c3m48j
https://escholarship.org/uc/item/70c3m48j
Autor:
Marlesa Godoy, Xia Yang, Jiwen Li, William G Pembroke, Lin Pan, Michael C. Condro, Harley I. Kornblum, Jessica E. Rexach, Steven A. Goldman, Daniel H. Geschwind, Linsey Stiles, Yen-Wei Chen, Angela Y. Chen, Ye Zhang, Mineli Harteni, Ina B. Wanner, Alvaro G. Alvarado
Publikováno v:
Nature communications, vol 12, iss 1
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse models and the similarities and differences between human and mouse astrocytes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fdf29ea59d3d4b1e05472ac4de6a42
https://escholarship.org/uc/item/2290r3jj
https://escholarship.org/uc/item/2290r3jj
Autor:
Ziyuan He, Namita Rout, Nadia Slisarenko, Marcelo J. Kuroda, Marissa Fahlberg, Elizabeth S. Didier, Naofumi Takahashi
Publikováno v:
Journal of leukocyte biology, vol 109, iss 6
J Leukoc Biol
Journal of Leukocyte Biology
J Leukoc Biol
Journal of Leukocyte Biology
Aging is characterized by a loss of bone marrow hematopoietic tissue, systemic chronic inflammation, and higher susceptibility to infectious and noninfectious diseases. We previously reported the tightly regulated kinetics and massive daily productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fb0cd6d3c107c9e1f0e0c18ab87a16
https://escholarship.org/uc/item/4113x2gg
https://escholarship.org/uc/item/4113x2gg
Autor:
Michael Downes, Maziar Hafezi-Bakhtiari, Joseph M. Valentine, Yuan Zhang, David J. Mangelsdorf, Xin Zhou, Christopher Liddle, Steven A. Kliewer, Jin Zhang, Ronald M. Evans, Yang Dai, Hadeel Ashayer, Lana Mamoun, Alan R. Saltiel, Mohammad Abu-Odeh, Shannon M. Reilly, Nima Ebadat, Ruth T. Yu, Omer Keinan
Publikováno v:
Cell reports, vol 35, iss 13
Cell Reports, Vol 35, Iss 13, Pp 109331-(2021)
Cell reports
Cell Reports, Vol 35, Iss 13, Pp 109331-(2021)
Cell reports
SUMMARY The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires autocrine FGF21 signaling. Adipose-specific deletion of the FGF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0b260b1979af2e3c71fec90fe8e1a2
https://escholarship.org/uc/item/2q37b2cj
https://escholarship.org/uc/item/2q37b2cj
Autor:
Eric Pearlman, Zeyu Chen, Kai Kessenbrock, Guadalupe Gutierrez, Remy Vu, Morgan Dragan, Daniel Haensel, Elyse Noelani Greenberg, Peng Sun, Yuling Shi, Xing Dai, Quy H. Nguyen, Jie Wu, Wei Han, Scott X. Atwood
Publikováno v:
The Journal of investigative dermatology, vol 141, iss 6
J Invest Dermatol
J Invest Dermatol
Psoriasis is a common inflammatory skin disease characterized by aberrant inflammation and epidermal hyperplasia. Molecular mechanisms that regulate psoriasis-like skin inflammation remain to be fully understood. Here, we show that the expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee5e23afd4dc78ec4a6b6a2db27135a
https://escholarship.org/uc/item/4673b0x9
https://escholarship.org/uc/item/4673b0x9
Autor:
Feiyang Ma, Yung Yu Wong, Matteo Pellegrini, Ryan Sun, Timothy E. O’Sullivan, Andrew D. Hildreth
Publikováno v:
Nature immunology, vol 22, iss 5
Nature immunology
Nature immunology
White adipose tissue (WAT) is an essential regulator of energy storage and systemic metabolic homeostasis. Regulatory networks consisting of immune and structural cells are necessary to maintain WAT metabolism, which can become impaired during obesit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7798c91bd91edeb5103eb3eacfffe4ce
https://escholarship.org/uc/item/5tr331k5
https://escholarship.org/uc/item/5tr331k5
Autor:
Maxence Le Vasseur, Marco Jost, Jodi Nunnari, Jiawei Xu, Justin Yamada, Jonathan R. Friedman, Michelle Salemi, Jonathan S. Weissman, Max A. Horlbeck, Martin Kampmann, Brett S. Phinney
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Dysfunction of the mitochondrial electron transport chain (mETC) is a major cause of human mitochondrial diseases. To identify determinants of mETC function, we screened a genome-wide human CRISPRi library under oxidative metabolic conditions with se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78a7a5e8add711d74ab5a9aaf6fc125
https://escholarship.org/uc/item/8c84c3zp
https://escholarship.org/uc/item/8c84c3zp