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Publikováno v:
Biochem Pharmacol
The Hedgehog (Hh) family of lipid-modified signaling proteins directs embryonic tissue patterning and postembryonic tissue homeostasis, and dysregulated Hh signaling drives familial and sporadic cancers. Hh ligands bind to and inhibit the tumor suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e41d47683cea1a2be693eb6730efed
https://escholarship.org/uc/item/1jh7c8jg
https://escholarship.org/uc/item/1jh7c8jg
Autor:
Anaïs Anton, Berati Cerikan, Laurent Chatel-Chaix, Felix Pahmeier, Aïssatou Aïcha Sow, Ralf Bartenschlager, Clément Mazeaud, Mirko Cortese, Wesley Freppel
Publikováno v:
Viruses, vol 13, iss 10
Viruses, Vol 13, Iss 2092, p 2092 (2021)
Viruses
Volume 13
Issue 10
Viruses, Vol 13, Iss 2092, p 2092 (2021)
Viruses
Volume 13
Issue 10
The dengue virus (DENV) causes the most prevalent arthropod-borne viral disease worldwide. While its incidence is increasing in many countries, there is no approved antiviral therapy currently available. In infected cells, the DENV induces extensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5eadadac322afb2c5a7b3e1a7b589b2
https://escholarship.org/uc/item/77k8z1x7
https://escholarship.org/uc/item/77k8z1x7
Publikováno v:
Dev Biol
Cells display distinct metabolic characteristics depending on its differentiation stage. The fuel type of the cells serves not only as a source of energy but also as a driver of differentiation. Glucose, the primary nutrient to the cells, is a critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fee9ba7af4f8e435609943e359acce
https://escholarship.org/uc/item/6mr5311b
https://escholarship.org/uc/item/6mr5311b
Autor:
Nicholas A. Larsen, Xiang Liu, Patricia Gee, Andrew Cook, Constantin Cretu, Melissa S. Jurica, Vladimir Pena, Anant A. Agrawal, Tuong-Vi Nguyen, Arun K. Ghosh
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Intron selection during the formation of prespliceosomes is a critical event in pre-mRNA splicing. Chemical modulation of intron selection has emerged as a route for cancer therapy. Splicing modulators alter the splicing patterns in cells by binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f425751521a803c9bd864ce99295a846
https://escholarship.org/uc/item/3sr415kn
https://escholarship.org/uc/item/3sr415kn
Autor:
Marlesa Godoy, Xia Yang, Jiwen Li, William G Pembroke, Lin Pan, Michael C. Condro, Harley I. Kornblum, Jessica E. Rexach, Steven A. Goldman, Daniel H. Geschwind, Linsey Stiles, Yen-Wei Chen, Angela Y. Chen, Ye Zhang, Mineli Harteni, Ina B. Wanner, Alvaro G. Alvarado
Publikováno v:
Nature communications, vol 12, iss 1
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Li, J, Pan, L, Godoy, M, Pembroke, W G, Rexach, J E, Condro, M C, Alvarado, A G, Harteni, M, Chen, Y-W, Stiles, L, Chen, A Y, Wanner, I B, Yang, X, Goldman, S A, Geschwind, D H, Kornblum, H & Zhang, Y 2021, ' Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes ', Nature Communications, vol. 12, no. 1, 3958 . https://doi.org/10.1038/s41467-021-24232-3
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse models and the similarities and differences between human and mouse astrocytes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fdf29ea59d3d4b1e05472ac4de6a42
https://escholarship.org/uc/item/2290r3jj
https://escholarship.org/uc/item/2290r3jj
Autor:
Ziyuan He, Namita Rout, Nadia Slisarenko, Marcelo J. Kuroda, Marissa Fahlberg, Elizabeth S. Didier, Naofumi Takahashi
Publikováno v:
Journal of leukocyte biology, vol 109, iss 6
J Leukoc Biol
Journal of Leukocyte Biology
J Leukoc Biol
Journal of Leukocyte Biology
Aging is characterized by a loss of bone marrow hematopoietic tissue, systemic chronic inflammation, and higher susceptibility to infectious and noninfectious diseases. We previously reported the tightly regulated kinetics and massive daily productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fb0cd6d3c107c9e1f0e0c18ab87a16
https://escholarship.org/uc/item/4113x2gg
https://escholarship.org/uc/item/4113x2gg
Autor:
Michael Downes, Maziar Hafezi-Bakhtiari, Joseph M. Valentine, Yuan Zhang, David J. Mangelsdorf, Xin Zhou, Christopher Liddle, Steven A. Kliewer, Jin Zhang, Ronald M. Evans, Yang Dai, Hadeel Ashayer, Lana Mamoun, Alan R. Saltiel, Mohammad Abu-Odeh, Shannon M. Reilly, Nima Ebadat, Ruth T. Yu, Omer Keinan
Publikováno v:
Cell reports, vol 35, iss 13
Cell Reports, Vol 35, Iss 13, Pp 109331-(2021)
Cell reports
Cell Reports, Vol 35, Iss 13, Pp 109331-(2021)
Cell reports
SUMMARY The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires autocrine FGF21 signaling. Adipose-specific deletion of the FGF2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0b260b1979af2e3c71fec90fe8e1a2
https://escholarship.org/uc/item/2q37b2cj
https://escholarship.org/uc/item/2q37b2cj
Autor:
Eric Pearlman, Zeyu Chen, Kai Kessenbrock, Guadalupe Gutierrez, Remy Vu, Morgan Dragan, Daniel Haensel, Elyse Noelani Greenberg, Peng Sun, Yuling Shi, Xing Dai, Quy H. Nguyen, Jie Wu, Wei Han, Scott X. Atwood
Publikováno v:
The Journal of investigative dermatology, vol 141, iss 6
J Invest Dermatol
J Invest Dermatol
Psoriasis is a common inflammatory skin disease characterized by aberrant inflammation and epidermal hyperplasia. Molecular mechanisms that regulate psoriasis-like skin inflammation remain to be fully understood. Here, we show that the expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee5e23afd4dc78ec4a6b6a2db27135a
https://escholarship.org/uc/item/4673b0x9
https://escholarship.org/uc/item/4673b0x9
Autor:
Maureen E. Fitzgerald, Min Liu, Patrick Tso, Alma L. Burlingame, Juan A. Oses-Prieto, Sarah Fourman, Supna Nair, Jie Qu, Aditi Bhargava, John H. Morris, W. Sean Davidson
Publikováno v:
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Apolipoprotein A4 (APOA4) is one of the most abundant and versatile apolipoproteins facilitating lipid transport and metabolism. APOA4 is synthesized in the small intestine, packaged onto chylomicrons, secreted into intestinal lymph and transported v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17132a94da4ee3a44ba303dc6cc158e
https://escholarship.org/uc/item/9qz2b8fw
https://escholarship.org/uc/item/9qz2b8fw
Autor:
Lei Gu, Zhefeng Guo
Publikováno v:
Biochem Biophys Res Commun
Formation of amyloid oligomers and fibrils underlies the pathogenesis of a number of neurodegenerative diseases such as Alzheimer's. One mechanism of action by which Aβ aggregates cause neuronal toxicity is through interactions with cellular membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ff0f641dd955e974ad1c19089da98f
https://escholarship.org/uc/item/5km9b1fh
https://escholarship.org/uc/item/5km9b1fh