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pro vyhledávání: '"Josee Gauthier"'
Autor:
Feng Ding, Nikolay V. Dokholyan, William Maixner, Luda Diatchenko, Shuangye Yin, Adrian W.R. Serohijos, Dustin G. Gibson, Josee Gauthier
Publikováno v:
Structure. (11):1683-1690
Opioids that stimulate the μ-opioid receptor (MOR1) are the most frequently prescribed and effective analgesics. Here we present a structural model of MOR1. Molecular dynamics simulations show a ligand-dependent increase in the conformational flexib