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Autor:
Jeffrey Boeren, Joost Gribnau
Publikováno v:
Current Opinion in Cell Biology, 70, 44-50. Elsevier Ltd.
X chromosome inactivation (XCI) ensures an equal gene dosage between the sexes in placental mammals. Xist, a modular multi-domain X-encoded long non-coding RNA coats the X chromosome in cis during XCI. Xist recruits chromatin remodelers and repressor
Autor:
Tamir Gonen, Chi Nguyen
Publikováno v:
Current Opinion in Structural Biology
Microcrystal electron diffraction (MicroED) was first coined and developed in 2013 at the Janelia Research Campus as a new modality in electron cryomicroscopy (cryoEM). Since then, MicroED has not only made important contributions in pushing the reso
Autor:
Mireia Rosell, Juan Fernández-Recio
Publikováno v:
Current Opinion in Structural Biology
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC. Repositorio Institucional del CSIC
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Computational docking approaches aim to overcome the limited availability of experimental structural data on protein–protein interactions, which are key in biology. The field is rapidly moving from the traditional docking methodologies for modeling
Publikováno v:
Neuroscience and Biobehavioral Reviews, 112, 392-409. Elsevier Ltd.
Neuroscience & Biobehavioral Reviews
Neuroscience & Biobehavioral Reviews
DNA methylation (DNAm) - an epigenetic process that regulates gene expression - may represent a mechanism for the biological embedding of early traumatic experiences, including childhood maltreatment. Here, we conducted the first systematic review of
Publikováno v:
Trends in Biochemical Sciences
The severe acute respiratory syndrome virus 2 (SARS-CoV-2) invades host cells by interacting with receptors/co-receptors, as well as other co-factors, via its spike (S) protein that further mediates the fusion between viral and cellular membranes. Th
Publikováno v:
Trends in Biochemical Sciences, 44(1), 64-74. Elsevier Ltd.
Ankyrin repeat and suppressor of cytokine signaling (SOCS) box (Asb) proteins are ubiquitin E3 ligases. The subfamily of six-ankyrin repeat domain-containing Asb proteins (Asb5, Asb9, Asb11, and Asb13) is of specific interest because they display unu
Autor:
Jacky G. Goetz, Raphael Gaudin
Publikováno v:
Trends in Cell Biology
Dissemination and replication of viruses into hosts is a multistep process where viral particles infect, navigate, and indoctrinate various cell types. Viruses can reach tissues that are distant from their infection site by subverting subcellular mec
Publikováno v:
Trends in Biochemical Sciences
The interplay between academics and society within the environment of the COVID-19 pandemic has impacted on scientists across the world, prompting reevaluation of how virtual toolboxes can be used to support responsible collaborative research practic
Autor:
Cathal McCarthy, Ali S. Khashan, Gerard W. O'Keeffe, Gillian M. Maher, Louise C. Kenny, Fergus P. McCarthy, Patricia M. Kearney
Publikováno v:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
Pre-eclampsia is a leading cause of maternal death and maternal and perinatal morbidity. Whilst the clinical manifestations of pre-eclampsia often occur in late pregnancy, the molecular events leading into the onset of this disease are thought to ori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f28f63b5b30a936913d52f3b634cd1
https://hdl.handle.net/10468/7137
https://hdl.handle.net/10468/7137
Autor:
Geoff Wild, Evan Mitchell
Publikováno v:
Journal of Theoretical Biology
Highlights • How does prophylactic host behaviour affect the evolution of an infectious disease? • The suite of prophylactic host behaviours comprises the “behavioural immune system”. • We find prophylactic host behaviour selects for lower