Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Timothy J. Mitchison"'
Publikováno v:
Cell
How tissues acquire complex shapes is a fundamental question in biology and regenerative medicine. Zebrafish semicircular canals form from invaginations in the otic epithelium (buds) that extend and fuse to form the hubs of each canal. We find that c
Autor:
Martine Ruer, Timothy J. Mitchison, Elvan Boke, Anthony A. Hyman, Martin Wühr, Steven P. Gygi, David N. Drechsel, Margaret Coughlin, Regis P. Lemaitre, Simon Alberti
Publikováno v:
Cell. 166:637-650
Most vertebrate oocytes contain a Balbiani body, a large, non-membrane-bound compartment packed with RNA, mitochondria, and other organelles. Little is known about this compartment, though it specifies germline identity in many non-mammalian vertebra
Autor:
Marc W. Kirschner, Marc Presler, Brian K. Erickson, Matthew Sonnett, Timothy J. Mitchison, Steven P. Gygi, Keisuke Ishihara, Graeme C. McAlister, Aaron C. Groen, Thomas Güttler, Leonid Peshkin, Martin Wühr
Publikováno v:
Current Biology. 25(20):2663-2671
SummaryThe composition of the nucleoplasm determines the behavior of key processes such as transcription, yet there is still no reliable and quantitative resource of nuclear proteins. Furthermore, it is still unclear how the distinct nuclear and cyto
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1808-1818 (2014)
Poly(ADP-ribose) polymerases (PARPs) catalyze poly(ADP-ribose) addition onto proteins, an important post-translational modification involved in transcription, DNA damage repair, and stem cell identity. Previous studies established the activation of P
Publikováno v:
Biophysical Journal. 104(6):1338-1348
Mitochondria maintain a constant rate of aerobic respiration over a wide range of oxygen levels. However, the control strategies underlying oxygen homeostasis are still unclear. Using mathematical modeling, we found that the mitochondrial electron tr
Publikováno v:
Current Biology. 21:815-824
Summary Background Midzones, also called central spindles, are an array of antiparallel microtubules that form during cytokinesis between the separated chromosomes. Midzones can be considered to be platforms that recruit specific proteins and orchest
Autor:
Timothy J. Mitchison
Publikováno v:
Cell. 157(5):1008-1010
Dynamic instability, the stochastic switching between growth and shrinkage, is essential for microtubule function. This behavior is driven by GTP hydrolysis in the microtubule lattice, and is inhibited by anticancer agents like Taxol. We provide new
Publikováno v:
Biophysical Journal. 99(7):2153-2162
Rapid assembly and disassembly (turnover) of actin filaments in cytoplasm drives cell motility and shape remodeling. While many biochemical processes that facilitate filament turnover are understood in isolation, it remains unclear how they work toge
Autor:
Sophie Dumont, Timothy J. Mitchison
Publikováno v:
Current Biology. 19(17):R749-R761
The mitotic spindle assembles to a steady-state length at metaphase through the integrated action of molecular mechanisms that generate and respond to mechanical forces. While molecular mechanisms that produce force have been described, our understan
Autor:
Timothy J. Mitchison, Sophie Dumont
Publikováno v:
Current Biology. 19:1086-1095
Summary Background Although the molecules involved in mitosis are becoming better characterized, we still lack an understanding of the emergent mechanical properties of the mitotic spindle. For example, we cannot explain how spindle length is determi