Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Theodore R. Holman"'
Autor:
Steven C. Perry, Christopher van Hoorebeke, James Sorrentino, Leslie Bautista, Oluwayomi Akinkugbe, William S. Conrad, Natalie Rutz, Theodore R. Holman
Publikováno v:
Archives of Biochemistry and Biophysics. 727:109317
Human 15-lipoxygenases (LOX) are critical enzymes in the inflammatory process, producing various pro-resolution molecules, such as lipoxins and resolvins, but the exact role each of the two 15-LOXs in these biosynthetic pathways remains elusive. Prev
Autor:
Matthew P. Jacobson, Nathan C. Gilbert, Wan-Chen Tsai, Adam Yasgar, Chakrapani Kalyanaraman, Michelle Armstrong, Melissa Standley, Anthony T. Iavarone, Amanda Ohler, David B. Neau, Ganesha Rai, Adam R. Offenbacher, Marcia E. Newcomer, Phillip Crews, Steve Perry, Anton Simeonov, Hsiau-Wei Lee, Ajit Jadhav, Theodore R. Holman
Publikováno v:
Bioorg Med Chem
Human epithelial 15-lipoxygenase-2 (h15-LOX-2, ALOX15B) is expressed in many tissues and has been implicated in atherosclerosis, cystic fibrosis and ferroptosis. However, there are few reported potent/selective inhibitors that are active ex vivo. In
Autor:
Theodore R. Holman, Melinee D’silva, Harman S. Brah, Wan-Chen Tsai, Jennyfer Tena, Ansari Mukhtar Aleem, Chakrapani Kalyanaraman, Mirella Rivera-Velazquez, Sarvind Tripathi, Matthew P. Jacobson, Jerry L. Nadler
Publikováno v:
Bioorganic & Medicinal Chemistry. 46:116347
Human platelet 12-(S)-Lipoxygenase (12-LOX) is a fatty acid metabolizing oxygenase that plays an important role in platelet activation and cardiometabolic disease. ML355 is a specific 12-LOX inhibitor that has been shown to decrease thrombosis withou
Autor:
Jesús Ceja, Kenneth Ikei, Theodore R. Holman, Michael Holinstat, Joanne Vesci, Patrick L. Apopa, Jennifer Yeung
Publikováno v:
Journal of Lipid Research. 53:2546-2559
Human platelet-type 12-lipoxygenase (12-LOX) has recently been shown to play an important role in regulation of human platelet function by reacting with arachidonic acid (AA). However, a number of other fatty acids are present on the platelet surface
Autor:
David J. Maloney, Yumi Imai, Ganesha Rai, Theodore R. Holman, Jerry L. Nadler, Anton Simeonov, Victor Kenyon, Jessica R. Weaver, David A. Taylor-Fishwick, Ajit Jadhav
Publikováno v:
Molecular and Cellular Endocrinology. 358:88-95
Elevated cellular reactive species, which can be produced by diabetic serum conditions such as elevated inflammatory cytokines, lipotoxicity or glucotoxicity contribute to islet beta cell dysfunction and cell death. Cellular pathways that result in b
Autor:
Vladimir A. Tyurin, Indira H. Shrivastava, Hülya Bayır, Gaowei Mao, David R. Emlet, Xiaoyan Wen, Andrew P. VanDemark, Simon C. Watkins, Theodore R. Holman, John A. Kellum, Tamil S. Anthonymuthu, Elizabeth M. Kenny, Alexandr A. Kapralov, Feng Qu, Valerian E. Kagan, Claudette M. St. Croix, Sally E. Wenzel, Ivet Bahar, Karolina Mikulska-Ruminska, Haider H. Dar, Yulia Y. Tyurina, Joel C. Rosenbaum, Louis J. Sparvero, Yoshinori Minami, Jinming Zhao, Qin Yang, Andrew A. Amoscato
Publikováno v:
Cell. 171:628-641.e26
Ferroptosis is a form of programmed cell death that is pathogenic to several acute and chronic diseases and executed via oxygenation of polyunsaturated phosphatidylethanolamines (PE) by 15-lipoxygenases (15-LO) that normally use free polyunsaturated
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:6534-6539
Recently, it has been shown that lipoxygenase (LO) products affect the substrate specificity of human 15-LO. In the current paper, we demonstrate that soybean LO-1 (sLO-1) is not affected by its own products, however, inhibitors which bind the allost
Autor:
Silvia Sepúlveda-Boza, Yesseny Vásquez-Martínez, Rachana V. Ohri, Theodore R. Holman, Victor Kenyon
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:7408-7425
Human lipoxygenase (hLO) isozymes have been implicated in a number of disease states and have attracted much attention with respect to their inhibition. One class of inhibitors, the flavonoids, have been shown to be potent lipoxygenase inhibitors but
Publikováno v:
Harmful Algae. 5:124-132
Heterosigma akashiwo (Hada) gives rise to red tides along the Atlantic and Pacific coasts and is known to produce brevetoxins. This investigation establishes baseline information showing the presence of H. akashiwo along the central California coast
Publikováno v:
Journal of Inorganic Biochemistry. 96:225