Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Patrick Rabe"'
Autor:
Philip Hinchliffe, Karina Calvopiña, Patrick Rabe, Maria F. Mojica, Christopher J. Schofield, Gary I. Dmitrienko, Robert A. Bonomo, Alejandro J. Vila, James Spencer
Publikováno v:
Journal of Biological Chemistry. 299:104606
Autor:
Xiao Liu, Raphael Reinbold, Shuang Liu, Ryan A. Herold, Patrick Rabe, Stéphanie Duclos, Rahul B. Yadav, Martine I. Abboud, Sandrine Thieffine, Fraser A. Armstrong, Lennart Brewitz, Christopher J. Schofield
Publikováno v:
Journal of Biological Chemistry. 299:102873
Variants of isocitrate dehydrogenase (IDH) 1 and 2 (IDH1/2) alter metabolism in cancer cells by catalyzing the NADPH-dependent reduction of 2-oxoglutate (2OG) to (2R)-hydroxyglutarate (2HG). However, it is unclear how derivatives of 2OG can affect ca