Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Michael J. Kruhlak"'
Publikováno v:
Biochemical and Biophysical Research Communications. 663:171-178
Autor:
Naritaka Tamaoki, Stefan Siebert, Takuya Maeda, Ngoc-Han Ha, Meghan L. Good, Yin Huang, Suman K. Vodnala, Juan J. Haro-Mora, Naoya Uchida, John F. Tisdale, Colin L. Sweeney, Uimook Choi, Julie Brault, Sherry Koontz, Harry L. Malech, Yasuhiro Yamazaki, Risa Isonaka, David S. Goldstein, Masaki Kimura, Takanori Takebe, Jizhong Zou, David F. Stroncek, Pamela G. Robey, Michael J. Kruhlak, Nicholas P. Restifo, Raul Vizcardo
Publikováno v:
Cell Reports Methods. 3:100460
Autor:
Benjamin L. Kidder, Daisuke Yamada, Takuya Maeda, Haruhiko Koseki, Li Jia, Meghan L. Good, Devikala Gurusamy, Zhiya Yu, Fumito Ito, David F. Stroncek, Marta Bosch-Marce, Naritaka Tamaoki, Zied Abdullaev, Nicholas D. Klemen, Nicholas P. Restifo, Amanda N. Henning, Chengyu Liu, Svetlana Pack, SM Rafiqul Islam, Douglas C. Palmer, Raul Vizcardo, Francis A. Flomerfelt, Michael J. Kruhlak
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3175-3190 (2018)
Summary: Induced pluripotent stem cell (iPSC)-derived T cells may provide future therapies for cancer patients, but those generated by current methods, such as the OP9/DLL1 system, have shown abnormalities that pose major barriers for clinical transl
Autor:
Gareth N. Corry, Juan Ausió, Darin McDonald, Hilmar Strickfaden, John Th'ng, Michèle Rouleau, Guy G. Poirier, Toyotaka Ishibashi, Jean-François Haince, Michael J. Kruhlak, D. Alan Underhill, Michael J. Hendzel
Publikováno v:
Journal of Biological Chemistry. 291:1789-1802
Chromatin undergoes a rapid ATP-dependent, ATM and H2AX-independent decondensation when DNA damage is introduced by laser microirradiation. Although the detailed mechanism of this decondensation remains to be determined, the kinetics of decondensatio
Autor:
Jeremy M. Stark, Andrea K. Byrum, Elsa Callen, Nancy Wong, Andre Stanlie, Yaakov Maman, Nima Mosammaparast, Raphael Souza Pavani, Michael J. Kruhlak, Amanda Day, Wei Wu, André Nussenzweig, Lavinia C. Dumitrache, Peter J. McKinnon, Dali Zong, Andres Canela, Maria A. Blasco, Carlos Mendez-Dorantes, Paula Martinez, Momoko Ishikawa
Publikováno v:
Mol Cell
Summary 53BP1 activity drives genome instability and lethality in BRCA1-deficient mice by inhibiting homologous recombination (HR). The anti-recombinogenic functions of 53BP1 require phosphorylation-dependent interactions with PTIP and RIF1/shieldin
Autor:
Jeremy A. Daniel, Oscar Fernandez-Capetillo, Anthony T. Tubbs, Ji-Eun Lee, Linda M. Starnes, Michael J. Kruhlak, Federica Polato, Frederick W. Alt, Hua Tang Chen, Kai Ge, Elsa Callen, Barry P. Sleckman, Michel C. Nussenzweig, Robert B. Faryabi, Margarida A. Santos, Maria Nieto-Soler, Duane R. Wesemann, André Nussenzweig, Michela Di Virgilio, Nancy Wong
Publikováno v:
Cell. 153:1266-1280
SummaryThe DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as opposed to homologous recombination (HR). During S phase, BRCA1 antagonizes 53BP1 to
Publikováno v:
Journal of Biological Chemistry. 287:40328-40338
IL-15 can either be transpresented by IL-15Rα or be secreted.New N- and C-terminal splice versions of human IL-15Rα determine whether IL-15 is secreted or stays bound to the cell membrane.IL-15Rα isoforms determine the mode of action of IL-15.IL-1
Autor:
Manuela Fahrleitner, Bernhard Nieswandt, Sabine Ring, Sven G. Meuth, Stephan Gnerlich, Alexander Enk, Stefan W. Schneider, Björn F. Krämer, Tanja Schönberger, Michael J. Kruhlak, Meinrad Gawaz, Sarah Gehring, Harald F. Langer, Anke S. Lonsdorf
Publikováno v:
Journal of Biological Chemistry. 287:2168-2178
A mutual relationship exists between metastasizing tumor cells and components of the coagulation cascade. The exact mechanisms as to how platelets influence blood-borne metastasis, however, remain poorly understood. Here, we used murine B16 melanoma
Autor:
Joseph M. Connors, Wing C. Chan, Peter Möller, Jan Delabie, Graham W. Slack, Andreas Rosenwald, Kerry J. Savage, David Levens, Vu N. Ngo, N. C. Tolga Emre, Erlend B. Smeland, Dennis D. Weisenburger, David G. Maloney, Lixin Rui, Georg Lenz, Elias Campo, Hong Zhao, Hye Jung Chung, Louis M. Staudt, Randy D. Gascoyne, Craig J. Thomas, George E. Wright, Christian Steidl, Michael J. Kruhlak, German Ott, Yandan Yang, John Powell, Elaine S. Jaffe, Hans K. Müller-Hermelink, R. Eric Davis, Lisa M. Rimsza, Arthur L. Shaffer, Wenming Xiao, Weihong Xu, Laurence Lamy
Publikováno v:
Cancer Cell. 18:590-605
SummaryChromosome band 9p24 is frequently amplified in primary mediastinal B cell lymphoma (PMBL) and Hodgkin lymphoma (HL). To identify oncogenes in this amplicon, we screened an RNA interference library targeting amplicon genes and thereby identifi
Autor:
David P. Bazett-Jones, Michael J. Hendzel, Melody A Lever, Natalie A.B MacLean, Michael J. Kruhlak, F.-Michel Boisvert
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 76:9-21
The cell nucleus is increasingly recognized as a spatially organized structure. In this review, the nature and controversies associated with nuclear compartmentalization are discussed. The relationship between nuclear structure and organization of pr