Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mauricio J. Reginato"'
Publikováno v:
Journal of Molecular Biology. 428:3282-3294
The hexosamine biosynthetic pathway (HBP) is highly dependent on multiple metabolic nutrients including glucose, glutamine, and acetyl-CoA. Increased flux through HBP leads to elevated post-translational addition of β-D-N-acetylglucosamine sugars to
Autor:
Pavel Dráber, Christos D. Katsetos, Agustin Legido, Jack A. Tuszyn´ski, Mauricio J. Reginato, Eduarda Dráberová, Peter W. Baas, Luca D'Agostino
Publikováno v:
Seminars in Pediatric Neurology. 22:49-72
Major advances in the genomics and epigenomics of diffuse gliomas and glioblastoma to date have not been translated into effective therapy, necessitating pursuit of alternative treatment approaches for these therapeutically challenging tumors. Curren
Autor:
Christina M. Ferrer, David J. Vocadlo, John N. Falcone, Tiffany N. Seagroves, Luciana P. Schwab, Valerie L. Sodi, Thomas P. Lynch, Danielle L. Peacock, Mauricio J. Reginato
Publikováno v:
Molecular Cell. 54(5):820-831
The hexosamine biosynthetic pathway elevates posttranslational addition of O-linked β-N-acetylglucosamine (O-GlcNAc) on intracellular proteins. Cancer cells elevate total O-GlcNAcylation by increasing O-GlcNAc transferase (OGT) and/or decreasing O-G
Autor:
Mauricio J. Reginato, Kenna R. Mills, Nicole L. Collins, Jayanta Debnath, Joan S. Brugge, Senthil K. Muthuswamy
Publikováno v:
Cell. 111:29-40
We have utilized in vitro three-dimensional epithelial cell cultures to analyze the role of apoptosis in the formation and maintenance of a hollow glandular architecture. Lumen formation is associated with the selective apoptosis of centrally located
Publikováno v:
Journal of Biological Chemistry. 271:28199-28205
Thyroid hormone receptors (TRs) require heterodimerization with retinoid X receptor (RXR) for maximum DNA binding affinity. Interaction with RXR occurs via two dimerization interfaces, one in the DNA-binding domain and one in the C-terminal "ninth he
Autor:
Mauricio J. Reginato, Richard A. Macia, Caroline H. Gochoco, Gregory A. Christensen, Choon K. Oh, Jayesh Vora
Publikováno v:
Journal of Controlled Release. 24:193-200
Growth hormone releasing peptide (GHRP-6) is a synthetic hexapeptide that stimulates the release of growth hormone in several animal species. The feasibility of developing an efficacious intranasal formulation of GHRP-6 is currently under considerati
Autor:
Jayanta Debnath, Kenna R. Mills, Nicole L. Collins, Mauricio J. Reginato, Senthil K. Muthuswamy, Joan S. Brugge
Publikováno v:
Cell. 111(5)
Publikováno v:
Journal of Biotechnology. 136:S119-S120
Autor:
Peter I. Lelkes, S. Heeg, Mauricio J. Reginato, Anil K. Rustgi, Gregory P. Botta, Maximilian Reichert
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 4, Pp 359-372 (2013)
Pancreatic ductal adenocarcinoma (PDAC) commonly contains a mutation in K-Ras(G12D) and is characterized by a desmoplastic reaction composed of deregulated, proliferating cells embedded in an abnormal extracellular matrix (ECM). Our previous observat